메뉴 건너뛰기




Volumn 26, Issue 10, 2012, Pages 1070-1085

Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release

Author keywords

C. elegans; Heterotrimeric G protein; mAChR; Sphingosine kinase; Synapse; Trio RhoGEF

Indexed keywords

ACETYLCHOLINE; MUSCARINIC AGENT; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE 1;

EID: 84861122343     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.188003.112     Document Type: Article
Times cited : (60)

References (85)
  • 5
    • 0034960521 scopus 로고    scopus 로고
    • The Trio family of guaninenucleotide-exchange factors: Regulators of axon guidance
    • Bateman J, Van Vactor D. 2001. The Trio family of guaninenucleotide-exchange factors: Regulators of axon guidance. J Cell Sci 114: 1973-1980.
    • (2001) J Cell Sci , vol.114 , pp. 1973-1980
    • Bateman, J.1    van Vactor, D.2
  • 7
    • 0036261720 scopus 로고    scopus 로고
    • Leukemia-associated Rho guanine nucleotide exchange factor promotes Gaq- coupled activation of RhoA
    • Booden MA, Siderovski DP, Der CJ. 2002. Leukemia-associated Rho guanine nucleotide exchange factor promotes Gaq- coupled activation of RhoA. Mol Cell Biol 22: 4053-4061.
    • (2002) Mol Cell Biol , vol.22 , pp. 4053-4061
    • Booden, M.A.1    Siderovski, D.P.2    Der, C.J.3
  • 8
    • 0036687577 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction
    • Brailoiu E, Cooper RL, Dun NJ. 2002. Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction. Br J Pharmacol 136: 1093-1097.
    • (2002) Br J Pharmacol , vol.136 , pp. 1093-1097
    • Brailoiu, E.1    Cooper, R.L.2    Dun, N.J.3
  • 9
    • 77954539153 scopus 로고    scopus 로고
    • Muscarinic acetylcholine receptors (mAChRs) in the nervous system: Some functions and mechanisms
    • Brown DA. 2010. Muscarinic acetylcholine receptors (mAChRs) in the nervous system: Some functions and mechanisms. J Mol Neurosci 41: 340-346.
    • (2010) J Mol Neurosci , vol.41 , pp. 340-346
    • Brown, D.A.1
  • 10
    • 50049121874 scopus 로고    scopus 로고
    • Regulation and functions of sphingosine kinases in the brain
    • Bryan L, Kordula T, Spiegel S, Milstien S. 2008. Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta 1781: 459-466.
    • (2008) Biochim Biophys Acta , vol.1781 , pp. 459-466
    • Bryan, L.1    Kordula, T.2    Spiegel, S.3    Milstien, S.4
  • 14
    • 57149117136 scopus 로고    scopus 로고
    • Profiling synaptic proteins identifies regulators of insulin secretion and lifespan
    • doi: 10.1371/journal.pgen.1000283
    • Ch'ng Q, Sieburth D, Kaplan JM. 2008. Profiling synaptic proteins identifies regulators of insulin secretion and lifespan. PLoS Genet 4: e1000283. doi: 10.1371/journal.pgen.1000283.
    • (2008) PLoS Genet , vol.4
    • Ch'ng, Q.1    Sieburth, D.2    Kaplan, J.M.3
  • 17
    • 33746627569 scopus 로고    scopus 로고
    • Factors regulating the abundance and localization of synaptobrevin in the plasma membrane
    • Dittman JS, Kaplan JM. 2006. Factors regulating the abundance and localization of synaptobrevin in the plasma membrane. Proc Natl Acad Sci 103: 11399-11404.
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 11399-11404
    • Dittman, J.S.1    Kaplan, J.M.2
  • 18
    • 79955744677 scopus 로고    scopus 로고
    • The cholinergic system and hippocampal plasticity
    • Drever BD, Riedel G, Platt B. 2011. The cholinergic system and hippocampal plasticity. Behav Brain Res 221: 505-514.
    • (2011) Behav Brain Res , vol.221 , pp. 505-514
    • Drever, B.D.1    Riedel, G.2    Platt, B.3
  • 19
    • 33745901961 scopus 로고    scopus 로고
    • Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling
    • Fernandez-Alfonso T, Kwan R, Ryan TA. 2006. Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling. Neuron 51: 179-186.
    • (2006) Neuron , vol.51 , pp. 179-186
    • Fernandez-Alfonso, T.1    Kwan, R.2    Ryan, T.A.3
  • 22
    • 0028128763 scopus 로고
    • Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • Ghosh TK, Bian J, Gill DL. 1994. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J Biol Chem 269: 22628-22635.
    • (1994) J Biol Chem , vol.269 , pp. 22628-22635
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 26
    • 0025844789 scopus 로고
    • Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
    • Hall DH, Hedgecock EM. 1991. Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans. Cell 65: 837-847.
    • (1991) Cell , vol.65 , pp. 837-847
    • Hall, D.H.1    Hedgecock, E.M.2
  • 27
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: Lessons from sphingolipids
    • Hannun YA, Obeid LM. 2008. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat Rev Mol Cell Biol 9: 139-150.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 28
    • 79151479103 scopus 로고    scopus 로고
    • Complexin maintains vesicles in the primed state in C. elegans
    • Hobson RJ, Liu Q, Watanabe S, Jorgensen EM. 2011. Complexin maintains vesicles in the primed state in C. elegans. Curr Biol 21: 106-113.
    • (2011) Curr Biol , vol.21 , pp. 106-113
    • Hobson, R.J.1    Liu, Q.2    Watanabe, S.3    Jorgensen, E.M.4
  • 29
    • 73649108890 scopus 로고    scopus 로고
    • Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1
    • Jarman KE, Moretti PA, Zebol JR, Pitson SM. 2010. Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1. J Biol Chem 285: 483-492.
    • (2010) J Biol Chem , vol.285 , pp. 483-492
    • Jarman, K.E.1    Moretti, P.A.2    Zebol, J.R.3    Pitson, S.M.4
  • 30
    • 77749311463 scopus 로고    scopus 로고
    • Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans
    • doi: 10.1371/journal.pone.0008857
    • Kage-Nakadai E, Kobuna H, Kimura M, Gengyo-Ando K, Inoue T, Arai H, Mitani S. 2010. Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. PLoS ONE 5: e8857. doi: 10.1371/journal.pone.0008857.
    • (2010) PLoS ONE , vol.5
    • Kage-Nakadai, E.1    Kobuna, H.2    Kimura, M.3    Gengyo-Ando, K.4    Inoue, T.5    Arai, H.6    Mitani, S.7
  • 31
    • 34247552132 scopus 로고    scopus 로고
    • Involvement of sphingosine-1-phosphate in gluta- mate secretion in hippocampal neurons
    • Kajimoto T, Okada T, Yu H, Goparaju SK, Jahangeer S, Nakamura S. 2007. Involvement of sphingosine-1-phosphate in gluta- mate secretion in hippocampal neurons. Mol Cell Biol 27: 3429-3440.
    • (2007) Mol Cell Biol , vol.27 , pp. 3429-3440
    • Kajimoto, T.1    Okada, T.2    Yu, H.3    Goparaju, S.K.4    Jahangeer, S.5    Nakamura, S.6
  • 33
    • 33646426428 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate activates BKCa channels indepen- dently of G protein-coupled receptor in human endothelial cells
    • 10.1152/ajpcell.00353.2005
    • Kim MY, Liang GH, Kim JA, Kim YJ, Oh S, Suh SH. 2006. Sphingosine-1-phosphate activates BKCa channels indepen- dently of G protein-coupled receptor in human endothelial cells. Am J Physiol Cell Physiol 290: C1000-C1008. doi: 10.1152/ajpcell.00353.2005
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Kim, M.Y.1    Liang, G.H.2    Kim, J.A.3    Kim, Y.J.4    Oh, S.5    Suh, S.H.6
  • 34
    • 0033213254 scopus 로고    scopus 로고
    • Facilitation of synaptic transmission by EGL-30 Gqa and EGL-8 PLCb: DAG binding to UNC-13 is required to stimulate acetylcholine release
    • Lackner MR, Nurrish SJ, Kaplan JM. 1999. Facilitation of synaptic transmission by EGL-30 Gqa and EGL-8 PLCb: DAG binding to UNC-13 is required to stimulate acetylcholine release. Neuron 24: 335-346.
    • (1999) Neuron , vol.24 , pp. 335-346
    • Lackner, M.R.1    Nurrish, S.J.2    Kaplan, J.M.3
  • 35
    • 33747588567 scopus 로고    scopus 로고
    • Cellular signalling by sphingosine kinase and sphingosine 1-phosphate
    • Leclercq TM, Pitson SM. 2006. Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. IUBMB Life 58: 467-472.
    • (2006) IUBMB Life , vol.58 , pp. 467-472
    • Leclercq, T.M.1    Pitson, S.M.2
  • 36
    • 34848904845 scopus 로고    scopus 로고
    • 2+/ calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction
    • 2+/ calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction. J Neurosci 27: 10404-10413.
    • (2007) J Neurosci , vol.27 , pp. 10404-10413
    • Liu, Q.1    Chen, B.2    Ge, Q.3    Wang, Z.W.4
  • 37
    • 33846941538 scopus 로고    scopus 로고
    • Ga(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior
    • Liu Y, LeBoeuf B, Garcia LR. 2007. Ga(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior. J Neurosci 27: 1411-1421.
    • (2007) J Neurosci , vol.27 , pp. 1411-1421
    • Liu, Y.1    Leboeuf, B.2    Garcia, L.R.3
  • 39
    • 29044447583 scopus 로고    scopus 로고
    • UNC-13 interaction with syntaxin is required for synaptic transmission
    • Madison JM, Nurrish S, Kaplan JM. 2005. UNC-13 interaction with syntaxin is required for synaptic transmission. Curr Biol 15: 2236-2242.
    • (2005) Curr Biol , vol.15 , pp. 2236-2242
    • Madison, J.M.1    Nurrish, S.2    Kaplan, J.M.3
  • 40
    • 0033613833 scopus 로고    scopus 로고
    • Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells
    • Mains RE, Alam MR, Johnson RC, Darlington DN, Back N, Hand TA, Eipper BA. 1999. Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells. J Biol Chem 274: 2929-2937.
    • (1999) J Biol Chem , vol.274 , pp. 2929-2937
    • Mains, R.E.1    Alam, M.R.2    Johnson, R.C.3    Darlington, D.N.4    Back, N.5    Hand, T.A.6    Eipper, B.A.7
  • 41
    • 79151478184 scopus 로고    scopus 로고
    • Complexin has opposite effects on two modes of synaptic vesicle fusion
    • Martin JA, Hu Z, Fenz KM, Fernandez J, Dittman JS. 2011. Complexin has opposite effects on two modes of synaptic vesicle fusion. Curr Biol 21: 97-105.
    • (2011) Curr Biol , vol.21 , pp. 97-105
    • Martin, J.A.1    Hu, Z.2    Fenz, K.M.3    Fernandez, J.4    Dittman, J.S.5
  • 42
    • 0027991078 scopus 로고
    • Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from in- ternal stores via an inositol trisphosphate-independent pathway
    • Mattie M, Brooker G, Spiegel S. 1994. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from in- ternal stores via an inositol trisphosphate-independent pathway. J Biol Chem 269: 3181-3188.
    • (1994) J Biol Chem , vol.269 , pp. 3181-3188
    • Mattie, M.1    Brooker, G.2    Spiegel, S.3
  • 43
    • 29944441832 scopus 로고    scopus 로고
    • Rho is a presynaptic activator of neurotransmitter release at pre- existing synapses in C. elegans
    • McMullan R, Hiley E, Morrison P, Nurrish SJ. 2006. Rho is a presynaptic activator of neurotransmitter release at pre- existing synapses in C. elegans. Genes Dev 20: 65-76.
    • (2006) Genes Dev , vol.20 , pp. 65-76
    • McMullan, R.1    Hiley, E.2    Morrison, P.3    Nurrish, S.J.4
  • 44
    • 0025942107 scopus 로고
    • Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V. 1991. Efficient gene transfer in C. elegans: Extrachromosomal maintenance and integration of transforming sequences. EMBO J 10: 3959-3970.
    • (1991) EMBO J , vol.10 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 48
    • 70349935745 scopus 로고    scopus 로고
    • Nerve growth factor, sphingomyelins, and sensitization in sensory neurons
    • Nicol GD. 2008. Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. Sheng Li Xue Bao 60: 603-604.
    • (2008) Sheng Li Xue Bao , vol.60 , pp. 603-604
    • Nicol, G.D.1
  • 49
    • 0033198830 scopus 로고    scopus 로고
    • Serotonin inhibition of synaptic transmission: Ga(0) decreases the abundance of UNC-13 at release sites
    • Nurrish S, Segalat L, Kaplan JM. 1999. Serotonin inhibition of synaptic transmission: Ga(0) decreases the abundance of UNC-13 at release sites. Neuron 24: 231-242.
    • (1999) Neuron , vol.24 , pp. 231-242
    • Nurrish, S.1    Segalat, L.2    Kaplan, J.M.3
  • 50
    • 56949105142 scopus 로고    scopus 로고
    • Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system
    • Okada T, Kajimoto T, Jahangeer S, Nakamura SI. 2009. Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system. Cell Signal 21: 7-13.
    • (2009) Cell Signal , vol.21 , pp. 7-13
    • Okada, T.1    Kajimoto, T.2    Jahangeer, S.3    Nakamura, S.I.4
  • 51
    • 43049168797 scopus 로고    scopus 로고
    • Unraveling the complexities of sphingosine- 1-phosphate function: The mast cell model
    • Olivera A. 2008. Unraveling the complexities of sphingosine- 1-phosphate function: The mast cell model. Prostaglandins Other Lipid Mediat 86: 1-11.
    • (2008) Prostaglandins Other Lipid Mediat , vol.86 , pp. 1-11
    • Olivera, A.1
  • 52
    • 0027371722 scopus 로고
    • Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens
    • Olivera A, Spiegel S. 1993. Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365: 557-560.
    • (1993) Nature , vol.365 , pp. 557-560
    • Olivera, A.1    Spiegel, S.2
  • 53
    • 79955707303 scopus 로고    scopus 로고
    • Neuronal polarity in C. elegans
    • Ou CY, Shen K. 2011. Neuronal polarity in C. elegans. Dev Neurobiol 71: 554-566.
    • (2011) Dev Neurobiol , vol.71 , pp. 554-566
    • Ou, C.Y.1    Shen, K.2
  • 54
    • 33745199617 scopus 로고    scopus 로고
    • i and trigger exocytosis in bovine chromaffin cells
    • 2+]i and trigger exocytosis in bovine chromaffin cells. Neuropharmacology 51: 18-26.
    • (2006) Neuropharmacology , vol.51 , pp. 18-26
    • Pan, C.Y.1    Lee, H.2    Chen, C.L.3
  • 55
    • 59649100571 scopus 로고    scopus 로고
    • Snapin facilitates the synchronization of synaptic vesicle fusion
    • Pan PY, Tian JH, Sheng ZH. 2009. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron 61: 412-424.
    • (2009) Neuron , vol.61 , pp. 412-424
    • Pan, P.Y.1    Tian, J.H.2    Sheng, Z.H.3
  • 56
    • 67650215189 scopus 로고    scopus 로고
    • A network of G-protein signaling pathways control neuronal activity in C. elegans
    • Perez-Mansilla B, Nurrish S. 2009. A network of G-protein signaling pathways control neuronal activity in C. elegans. Adv Genet 65: 145-192.
    • (2009) Adv Genet , vol.65 , pp. 145-192
    • Perez-Mansilla, B.1    Nurrish, S.2
  • 57
    • 25444483556 scopus 로고    scopus 로고
    • Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways
    • doi: 10.1186/1465-9921-6-48
    • Pfaff M, Powaga N, Akinci S, Schutz W, Banno Y, Wiegand S, Kummer W, Wess J, Haberberger RV. 2005. Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respir Res 6: 48. doi: 10.1186/1465-9921-6-48
    • (2005) Respir Res , vol.6 , pp. 48
    • Pfaff, M.1    Powaga, N.2    Akinci, S.3    Schutz, W.4    Banno, Y.5    Wiegand, S.6    Kummer, W.7    Wess, J.8    Haberberger, R.V.9
  • 58
    • 79551614173 scopus 로고    scopus 로고
    • Regulation of sphingosine kinase and sphingolipid signaling
    • Pitson SM. 2011. Regulation of sphingosine kinase and sphingolipid signaling. Trends Biochem Sci 36: 97-107.
    • (2011) Trends Biochem Sci , vol.36 , pp. 97-107
    • Pitson, S.M.1
  • 61
    • 0024669454 scopus 로고
    • Genetic analysis of the cha-1-unc-17 gene complex in Caenorhabditis
    • Rand JB. 1989. Genetic analysis of the cha-1-unc-17 gene complex in Caenorhabditis. Genetics 122: 73-80.
    • (1989) Genetics , vol.122 , pp. 73-80
    • Rand, J.B.1
  • 62
    • 0033361969 scopus 로고    scopus 로고
    • One GABA and two acetyl- choline receptors function at the C. elegans neuromuscular junction
    • Richmond JE, Jorgensen EM. 1999. One GABA and two acetyl- choline receptors function at the C. elegans neuromuscular junction. Nat Neurosci 2: 791-797.
    • (1999) Nat Neurosci , vol.2 , pp. 791-797
    • Richmond, J.E.1    Jorgensen, E.M.2
  • 63
    • 0033349884 scopus 로고    scopus 로고
    • UNC-13 is required for synaptic vesicle fusion in C. elegans
    • Richmond JE, Davis WS, Jorgensen EM. 1999. UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci 2: 959-964.
    • (1999) Nat Neurosci , vol.2 , pp. 959-964
    • Richmond, J.E.1    Davis, W.S.2    Jorgensen, E.M.3
  • 64
    • 0035913332 scopus 로고    scopus 로고
    • An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
    • Richmond JE, Weimer RM, Jorgensen EM. 2001. An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature 412: 338-341.
    • (2001) Nature , vol.412 , pp. 338-341
    • Richmond, J.E.1    Weimer, R.M.2    Jorgensen, E.M.3
  • 67
    • 79851480014 scopus 로고    scopus 로고
    • Gaq and phospholipase C-b: Turn on, turn off, and do it fast
    • doi: 10.1126/scisignal. 2001798
    • Ross EM. 2011. Gaq and phospholipase C-b: Turn on, turn off, and do it fast. Sci Signal 4: pe5. doi: 10.1126/scisignal. 2001798
    • (2011) Sci Signal , vol.4 , Issue.5
    • Ross, E.M.1
  • 68
    • 0242570882 scopus 로고    scopus 로고
    • The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling
    • Rumenapp U, Asmus M, Schablowski H, Woznicki M, Han L, Jakobs KH, Fahimi-Vahid M, Michalek C, Wieland T, Schmidt M. 2001. The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq-type G proteins: Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. J Biol Chem 276: 2474-2479.
    • (2001) J Biol Chem , vol.276 , pp. 2474-2479
    • Rumenapp, U.1    Asmus, M.2    Schablowski, H.3    Woznicki, M.4    Han, L.5    Jakobs, K.H.6    Fahimi-Vahid, M.7    Michalek, C.8    Wieland, T.9    Schmidt, M.10
  • 69
    • 25844457390 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells
    • Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S, Spiegel S. 2005. Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett 579: 5313-5317.
    • (2005) FEBS Lett , vol.579 , pp. 5313-5317
    • Sarkar, S.1    Maceyka, M.2    Hait, N.C.3    Paugh, S.W.4    Sankala, H.5    Milstien, S.6    Spiegel, S.7
  • 72
    • 0034097714 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate: A ligand for the EDG-1 family of G-protein-coupled receptors
    • Spiegel S. 2000. Sphingosine 1-phosphate: A ligand for the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci 905: 54-60.
    • (2000) Ann N Y Acad Sci , vol.905 , pp. 54-60
    • Spiegel, S.1
  • 75
    • 3142713002 scopus 로고    scopus 로고
    • The GAR-3 muscarinic receptor cooperates with calcium signals to regulate muscle contraction in the Caenorhabditis elegans pharynx
    • Steger KA, Avery L. 2004. The GAR-3 muscarinic receptor cooperates with calcium signals to regulate muscle contraction in the Caenorhabditis elegans pharynx. Genetics 167: 633-643.
    • (2004) Genetics , vol.167 , pp. 633-643
    • Steger, K.A.1    Avery, L.2
  • 76
    • 24344445483 scopus 로고    scopus 로고
    • The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans
    • Steven R, Zhang L, Culotti J, Pawson T. 2005. The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans. Genes Dev 19: 2016-2029.
    • (2005) Genes Dev , vol.19 , pp. 2016-2029
    • Steven, R.1    Zhang, L.2    Culotti, J.3    Pawson, T.4
  • 77
    • 33744951972 scopus 로고    scopus 로고
    • The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane
    • Sutherland CM, Moretti PA, Hewitt NM, Bagley CJ, Vadas MA, Pitson SM. 2006. The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. J Biol Chem 281: 11693-11701.
    • (2006) J Biol Chem , vol.281 , pp. 11693-11701
    • Sutherland, C.M.1    Moretti, P.A.2    Hewitt, N.M.3    Bagley, C.J.4    Vadas, M.A.5    Pitson, S.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.