Enhanced kinetic solubility profiles of indomethacin amorphous solid dispersions in poly(2-hydroxyethyl methacrylate) hydrogels

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 1, 2012, Pages 149-158

  Sun, Dajun D ^a   Ju, Tzu Chi Rob ^b   Lee, Ping I ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Amorphous solid dispersion; Indomethacin; Kinetic solubility; Poly (2 hydroxyethyl methacrylate); Supersaturation

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; INDOMETACIN; POLYMACON; POLYMER; POVIDONE; WATER;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED RELEASE FORMULATION; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DRUG SOLUBILITY; HYDROGEL; KINETICS; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRECIPITATION; SOLID; SOLUBILITY; TEMPERATURE; X RAY DIFFRACTION;

CROSS-LINKING REAGENTS; CRYSTALLIZATION; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; FEASIBILITY STUDIES; HUMIDITY; HYDROGELS; INDOMETHACIN; KINETICS; METHYLCELLULOSE; PARTICLE SIZE; PHASE TRANSITION; POLYHYDROXYETHYL METHACRYLATE; POVIDONE; SOLUBILITY; TIME FACTORS; X-RAY DIFFRACTION;

EID: 84861096450     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.12.016     Document Type: Article

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