Beneficial effects of montelukast against methotrexate-induced liver toxicity: A biochemical and histological study

The Scientific World Journal

Volumn 2012, Issue , 2012, Pages

  Kose, Evren ^a   Sapmaz, Hilal Irmak ^a   Sarihan, Ediz ^b   Vardi, Nigar ^b   Turkoz, Yusuf ^b   Ekinci, Nihat ^a  

^a INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b INONU UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; GLYCOGEN; MALONALDEHYDE; METHOTREXATE; MONTELUKAST; MYELOPEROXIDASE; NOTTA; UNCLASSIFIED DRUG; ACETIC ACID DERIVATIVE; PEROXIDASE; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EOSINOPHIL; FEMALE; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; LIVER INJURY; LIVER TOXICITY; NONHUMAN; PERIODIC ACID SCHIFF STAIN; RAT; SINGLE DRUG DOSE; ANIMAL; DRUG SCREENING; LIVER; LIVER CELL; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; TOXIC HEPATITIS; WISTAR RAT;

RATTUS;

ACETATES; ANIMALS; DRUG EVALUATION, PRECLINICAL; DRUG-INDUCED LIVER INJURY; FEMALE; GLUTATHIONE; GLYCOGEN; HEPATOCYTES; LIVER; MALONDIALDEHYDE; METHOTREXATE; OXIDATIVE STRESS; PERIODIC ACID-SCHIFF REACTION; PEROXIDASE; QUINOLINES; RATS; RATS, WISTAR;

EID: 84861083157     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/2012/987508     Document Type: Article

References (42)

1. Bayram M., Ozogul C., Dursun A., Ercan Z. S., Isik I., Dilekoz E., Light and electron microscope examination of the effects of methotrexate on the endosalpinx European Journal of Obstetrics Gynecology and Reproductive Biology 2005 120 1 96 103 (Pubitemid 40615080)
2. Widemann B. C., Balis F. M., Kempf-Bielack B., Bielack S., Pratt C. B., Ferrari S., Bacci G., Craft A. W., Adamson P. C., High-dose methotrexate-induced nephrotoxicity in patients with osteosarcoma: incidence, treatment, and outcome Cancer 2004 100 10 2222 2232 (Pubitemid 38580344)
3. Vardi N., Parlakpinar H., Cetin A., Erdogan A., Ozturk I. C., Protective effect of -carotene on methotrexate-induced oxidative liver damage Toxicologic Pathology 2010 38 4 592 597
4. Vardi N., Parlakpinar H., Ozturk F., Ates B., Gul M., Cetin A., Erdogan A., Otlu A., Potent protective effect of apricot and -carotene on methotrexate-induced intestinal oxidative damage in rats Food and Chemical Toxicology 2008 46 9 3015 3022
5. West S. G., Methotrexate hepatoxicity Rheumatic Disease Clinics of North America 1997 23 883 915
6. ener G., Ekiolu-Demiralp E., etiner M., Ercan F., Yeen B.., -glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects European Journal of Pharmacology 2006 542 13 170 178 (Pubitemid 44066363)
7. Uraz S., Tahan V., Aygun C., Eren F., Unluguzel G., Yuksel M., Senturk O., Avsar E., Haklar G., Celikel C., Hulagu S., Tozun N., Role of ursodeoxycholic acid in prevention of methotrexate-induced liver toxicity Digestive Diseases and Sciences 2008 53 4 1071 1077 (Pubitemid 351379813)
8. Cuciureanu M., Cruntu I. D., Pduraru O., Stoica B., Jerca L., Crauciuc E., Nechifor M., The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat Prostaglandins and Other Lipid Mediators 2009 88 3-4 82 88
9. ener G., Sakarcan A., ehirli., Ekiolu-Demiralp E., ener E., Ercan F., Gedik N., Yeen B. C., Chronic renal failure-induced multiple-organ injury in rats is alleviated by the selective CysLT1 receptor antagonist montelukast Prostaglandins and Other Lipid Mediators 2007 83 4 257 267 (Pubitemid 46710463)
10. Beytur A., Ciftci O., Oguz F., Oguzturk H., Yilmaz F., Montelukast attenuates side effects of cisplatin including testicular, spermatological, and hormonal damage in male rats Cancer Chemotherapy and Pharmacology 2012 69 1 207 213
11. Kose E., Beytur A., Vardi N., The effects of montelukast against methotrexate-induced acute renal damage Journal of Inonu University Medical Faculty 2011 18 2 73 77
12. Mohamadin A. M., Elberry A. A., Elkablawy M. A., Gawad H. S.A., Al-Abbasi F. A., Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver Pathophysiology 2011 18 3 235 242
13. zkan E., Yardimci S., Dulundu E., Topalolu., ehirli., Ercan F., Veliolu-n A., ener G., Protective potential of montelukast against hepatic ischemia/reperfusion injury in rats Journal of Surgical Research 2010 159 1 588 594
14. Ozturk H., Ozturk H., Gideroglu K., Terzi H., Bugdayci G., Montelukast protects against testes ischemia/reperfusion injury in rats Journal of the Canadian Urological Association 2010 4 3 173 178
15. Uchiyama M., Mihara M., Determination of malonaldehyde precursor in tissues by thiobarbituric acid test Analytical Biochemistry 1978 86 1 271 278 (Pubitemid 9050395)
16. Elman G. L., Tissue sulphydryl groups Archives of Biochemistry and Biophysics 1959 82 70 77
17. Wei H., Frenkel K., Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters Carcinogenesis 1993 14 6 1195 1201 (Pubitemid 23193551)
18. Sawhney P., Giammona C. J., Meistrich M. L., Richburg J. H., Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice Journal of Andrology 2005 26 1 136 145 (Pubitemid 39665287)
19. Ciftci O., Ozdemir I., Vardi N., Gurbuz N., Novel platinum-N-heterocyclic carbene complex is more cardiotoxic than cis-platin in rats Human and Experimental Toxicology 2011 30 9 1342 1349
20. Ateahin A., anna E., Trk G., eribai A. O., Yilmaz S., Yce A., Bulmu., Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats Journal of Pineal Research 2006 41 1 21 27 (Pubitemid 43980691)
21. Vonen B., Morland J., Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs Archives of Toxicology 1984 56 1 33 37 (Pubitemid 15186318)
22. Jahovic N., evik H., ehirli A.., Yeen B.., ener G., Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats Journal of Pineal Research 2003 34 4 282 287 (Pubitemid 36469775)
23. Neuman M. G., Cameron R. G., Haber J. A., Katz G. G., Malkiewicz I. M., Shear N. H., Inducers of cytochrome P450 2E1 enhance methotrexate-induced hepatocytotoxicity Clinical Biochemistry 1999 32 7 519 536 (Pubitemid 30007763)
24. Sahna E., Parlakpinar H., Cihan O. F., Turkoz Y., Acet A., Effects of aminoguanidine against renal ischaemia-reperfusion injury in rats Cell Biochemistry and Function 2006 24 2 137 141
25. Parks D. A., Granger D. N., Ischemia-reperfusion injury: a radical view Hepatology 1988 8 3 680 682
26. etin A., Kaynar L., Kocyigit I., Hacioglu S. K., Saraymen R., Ozturk A., Sari I., Sagdic O., Role of grape seed extract on methotrexate induced oxidative stress in rat liver The American Journal of Chinese Medicine 2008 36 5 861 872
27. Hemeida R. A., Mohafez O. M., Curcumin attenuates methotraxate-induced hepatic oxidative damage in rats Journal of the Egyptian National Cancer Institute 2008 20 2 141 148
28. Bhalla P., Dhawan D. K., Protective role of lithium in ameliorating the aluminium-induced oxidative stress and histological changes in rat brain Cellular and Molecular Neurobiology 2009 29 4 513 521
29. Kolli V. K., Abraham P., Rabi S., Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat Archives of Toxicology 2008 82 10 763 770
30. Sullivan G. W., Sarembock I. J., Linden J., The role of inflammation in vascular diseases Journal of Leukocyte Biology 2000 67 5 591 602
31. Ciftci O., Aydin M., Ozdemir I., Vardi N., Quercetin prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced testicular damage in rats. Andrologia. In press
32. Ciftci O., Ozdemir I., Tanyildizi S., Yildiz S., Oguzturk H., Antioxidative effects of curcumin, -myrcene and 1,8-cineole against 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced oxidative stress in rats liver Toxicology and Industrial Health 2011 27 5 447 453
33. Ozbek E., Cekmen M., Simsek A., Turkoz Y., Soylu A., Ilbey Y. O., Balbay M. D., Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele International Urology and Nephrology 2008 40 3 679 683
34. Canbay E., Agachan B., Ozturk T., Giris M., Asoglu O., Balik E., Bugra D., Dual inhibition of wound healing and oxidative process by montelukast in experimental colon anastomoses Surgical Innovation 2010 17 3 248 255
35. ener G., ehirli O., Veliolu-n A., etinel S., Gedik N., Caner M., Sakarcan A., Yeen B. C., Montelukast protects against renal ischemia/reperfusion injury in rats Pharmacological Research 2006 54 1 65 71 (Pubitemid 43850825)
36. Damtew B., Marino J. A., Fratianne R. B., Spagnuolo P. J., Neutrophil lipoxygenase metabolism and adhesive function following acute thermal injury Journal of Laboratory and Clinical Medicine 1993 121 2 328 336 (Pubitemid 23073140)
37. Wallace J. L., Beck P. L., Morris G. P., Is there a role for leukotrienes as mediators of ethanol-induced gastric mucosal damage? American Journal of Physiology 1988 254 1 17/1 (Pubitemid 18054489)
38. Carsin H., Bargues L., Stéphanazzi J., Paris A., Aubert P., Le Béver H., Inflammatory reaction and sepsis in severely burned patients Pathologie Biologie 2002 50 2 93 101 (Pubitemid 34225498)
39. ener G., Kabasakal L., etinel., Contuk G., Gedik N., Yeen B. C., Leukotriene receptor blocker montelukast protects against burn-induced oxidative injury of the skin and remote organs Burns 2005 31 5 587 596 (Pubitemid 40905216)
40. Turtay M. G., Firat C., Samdanci E., Oguzturk H., Erbatur S., Colak C., Effects of montelukast on burn wound healing in a rat model Clinical and Investigative Medicine 2010 33 6 E413 E421
41. Coskun A. K., Yigiter M., Oral A., Odabasoglu F., Halici Z., Mentes O., Cadirci E., Atalay F., Suleyman H., The effects of montelukast on antioxidant enzymes and proinflammatory cytokines on the heart, liver, lungs, and kidneys in a rat model of cecal ligation and puncture-induced sepsis TheScientificWorldJournal 2011 11 1341 1356
42. Meng X. J., Carruth M. W., Weinman S. A., Leukotriene D4 activates a chloride conductance in hepatocytes from lipopolysaccharide-treated rats Journal of Clinical Investigation 1997 99 12 2915 2922 (Pubitemid 27278668)