Modulation of central serotonin affects emotional information processing in impulsive aggressive personality disorder

Journal of Clinical Psychopharmacology

Volumn 32, Issue 3, 2012, Pages 329-335

  Lee, Royce J ^a   Gill, Andrew ^a   Chen, Bing ^a   McCloskey, Michael ^b   Coccaro, Emil F ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

aggression; emotions; serotonin; tryptophan depletion

Indexed keywords

SEROTONIN; TRYPTOPHAN;

ADULT; ANGER; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EMOTION; FACE; FEAR; FEMALE; FOLLOW UP; HUMAN; IMPULSIVE AGGRESSIVE PERSONALITY DISORDER; MALE; PERSONALITY DISORDER; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; SEX DIFFERENCE;

ADULT; AGGRESSION; AMINO ACIDS; ANGER; CROSS-SECTIONAL STUDIES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DIET; FEMALE; FOLLOW-UP STUDIES; HEART RATE; HUMANS; IMPULSE CONTROL DISORDERS; IMPULSIVE BEHAVIOR; MALE; MENTAL PROCESSES; PERSONALITY DISORDERS; RECOGNITION (PSYCHOLOGY); SEROTONIN; SEX CHARACTERISTICS; TRYPTOPHAN;

EID: 84861082640     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e31825368b7     Document Type: Article

References (58)

1. Coccaro EF, Kavoussi RJ, Coccaro EF, et al. Central serotonin and aggression: Inverse relationship with prolactin response to D-fenfluramine, but not with CSF 5-HIAA concentration in human subjects. Am J Psychiatry. 1997;154:1430-1435.
2. Young SN, Ervin FR, Pihl RO, et al. Biochemical aspects of tryptophan depletion in primates. Psychopharmacology (Berl). 1989;98:508-511.
3. Delgado PL, Charney DS, Price LH, et al. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant induced remission by rapid depletion of plasma tryptophan. Arch Gen Psychiatry. 1990;47:411-418.
4. Carpenter LL, Anderson GM, Pelton GH, et al. Tryptophan depletion during continuous CSF sampling in healthy human subjects. Neuropsychopharmacology. 1998;19:27-35.
5. Young SN, Pihl RO, Ervin FR. The effect of altered tryptophan levels on mood and behavior in normal human males. Clin Neuropharmacol. 1988;11:S207-S215.
6. Smith SE, Pihl RO, Young SN, et al. A test of possible cognitive and environmental influences on the mood lowering effect of tryptophan depletion in normal males. Psychopharmacology (Berl). 1987;91:451-457.
7. Booij L, Van der Does AJW, Riedel WJ. Monoamine depletion in psychiatric and healthy populations: Review. Mol Psychiatry. 2003;8:951-973.
8. Harmer C, Rogers R, Tunbridge E, et al. Tryptophan depletion decreases the recognition of fear in female volunteers. Psychopharmacology. 2003;167:411-417.
9. Attenburrow MJ, Williams C, Odantiadis J, et al. Acute administration of nutritionally sourced tryptophan increases fear recognition. Psychopharmacology. 2003;169:104-107.
10. Murphy FC, Smith KA, Cowen PJ, et al. The effects of tryptophan depletion on cognitive and affective processing in healthy volunteers. Psychopharmacology (Berl). 2002;163:52-53.
11. Cools R, Calder AJ, Lawrence AD, et al. Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces. Psychopharmacology. 2005;180:670-679.
12. Best M, Williams JM, Coccaro EF. Evidence for a dysfunctional prefrontal circuit in patients with an impulsive aggressive disorder. Proc Natl Acad Sci U S A. 2002;99:8448-8453.
13. Coccaro EF, McCloskey MS, Fitzgerald DA, et al. Amygdala and orbitofrontal reactivity to social threat in individuals with impulsive aggression. Biol Psychiatry. 2007;62:168-178.
14. Dougherty DM, Bjork JM, Marsh DM, et al. Influence of trait hostility on tryptophan depletion induced laboratory aggression. Psychiatry Res. 1999;29:227-232.
15. Kimbrell TA, George MS, Parekh PI, et al. Regional brain activity during transient self-induced anxiety and anger in healthy adults. Biol Psychiatry. 1999;46:454-465.
16. Blair RJR, Morris JS, Frith CD, et al. Dissociable neural responses to facial expressions of sadness and anger. Brain. 1999;122:883-893.
17. Marek GJ, Aghajanian GK. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 1997;36:589-599.
18. Rubia K, Lee F, Cleare AJ, et al. Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI. Psychopharmacology (Berl). 2005;179:791-803.
19. Zhang ZW, Arsenault D. Gain modulation by serotonin in pyramidal neurones of the rat prefrontal cortex. J Physiol. 2005;566:379-394.
20. Frankle WG, Lombardo I, New AS, et al. Brain serotonin transporter distribution in subjects with impulsive aggressivity: A positron emission study with [11C]McN 5652. Am J Psychiatry. 2005;162:915-923.
21. Leyton M, Okazawa H, Diksic M, et al. Brain regional -[11C]methyl-L- tryptophan trapping in impulsive subjects with borderline personality disorder. Am J Psychiatry. 2001;158:775-782.
22. Booij L, Tremblay RE, Leyton M, et al. Brain serotonin synthesis in adult males characterized by physical aggression during childhood: A 21-year longitudinal study. PLOS One. 2010;5:1-9.
23. Siever LJ, Buchsbaum MS, New AS, et al. D,L-Fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology. 1999;20:413-423.
24. Soloff PH, Meltzer CC, Greer PJ, et al. A fenfluramine activated FDG-PET study of borderline personality disorder. Biol Psychiatry. 2000;47:540-547.
25. New AS, Hazlett EA, Buchsbaum MS, et al. Blunted prefrontal cortical 18 fluorodeoxyglucose positron emission tomography response to meta- chlorophenypiperazine in impulsive aggression. Arch Gen Psychiatry. 2002;59:621-629.
26. Parsey RV, Oquendo MA, Simpson NR, et al. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res. 2002;954:173-182.
27. Coccaro EF. Intermittent explosive disorder. In: Coccaro EF, ed. Aggression: Psychiatric Assessment and Treatment. New York, NY: Marcel Dekker; 2003;149:9.
28. Coccaro EF. Intermittent explosive disorder. In: Coccaro EF, ed. Aggression: Psychiatric Treatment and Assessment. New York, NY: Marcel Dekker; 1997:149-166.
29. Pfohl B, Blum N, Zimmerman M. Structured Interview for the Diagnosis of DSM Personality Disorders. Iowa City, IA: U. Iowa College of Medicine; 1989.
30. Kosten TA, Rounsaville BJ. Sensitivity of psychiatric diagnosis based on the best estimate procedure. Am J Psychiatry. 1999;149:1225-1227.
31. Ekman P, FriesenW. Pictures of facial affect. Palo Alto, CA: Consulting Psychologists Press; 1976.
32. Hayward G, Goodwin GM, Cowen PJ, et al. Low-dose tryptophan depletion in recovered depressed patients induces changes in cognitive processing without depressive symptoms. Biol Psychiatry. 2005;57:517-524.
33. Van der Veen FM, Evers EAT, Deutz NEP, et al. Effects of acute tryptophan depletion on mood and facial emotion perception related brain activation and performance in healthy women with and without a family history of depression. Neuropsychopharmacology. 2007;32:216-224.
34. Saarela MV, Hlushchuk Y,Williams AC, et al. The compassionate brain: Humans detect intensity of pain from another's face. Cereb Cortex. 2007;17:230-237.
35. Glascher J, Tuscher O, Weiller C, et al. Elevated responses to constant facial emotions in different faces in the human amygdala: An fMRI study of facial identity and expression. BMC Neurosci. 2004;5:45.
36. Cleare AJ, Bond AJ. The effect of tryptophan depletion and enhancement on subjective and behavioral aggression in normal male subjects. Psychopharmacology (Berl). 1995;118:72-81.
37. Schmeck K, Sadigorsky S, Englert E, et al. Mood changes following acute tryptophan depletion in healthy adults. Psychopathology. 2002;35:234-240.
38. Neumeister A, Hu XZ, Luckenbaugh DA, et al. Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch Gen Psychiatry. 2006;63:978-968.
39. Tiedens LZ. The effect of anger on the hostile inferences of aggressive and nonaggressive people: Specific emotions, cognitive processing, and chronic accessibility. Motiv Emotion. 2001;25:233-250.
40. Keltner D, Ellsworth PC, Edwards K. Beyond simple pessimism: Effects of sadness and anger on social perception. J Pers Soc Psychol. 1993;64:740-752.
41. Davies SJ, Hood SD, Argyropoulos SV, et al. Depleting serotonin enhances both cardiovascular and psychological stress reactivity in recovered patients with anxiety disorders. J Clin Psychopharmacol. 2006;26:414-418.
42. Booij, L, Swenne CA, Brosschot JF, et al. Tryptophan depletion affects heart rate variability and impulsivity in remitted depressed patients with a history of suicidal ideation. Biol Psychiatry. 2006;60:507-514.
43. Kellett DO, Stanford SC, Machado BH, et al. Effect of 5-HT depletion on cardiovascular vagal reflex sensitivity in awake and anesthetized rats. Brain Res. 2005;105:61-72.
44. Theyer JF, Brosschot JF. Psychosomatics and psychopathology: Looking up and down from the brain. Psychoneuroendocrinology. 2005;30:1050-1058.
45. Okazawa H, Leyton M, Benkelfat C, et al. Statistical mapping analysis of serotonin synthesis images generated in healthy volunteers using positron-emission tomography and - [11C]methyl-L-tryptophan. J Psychiatry Neurosci. 2000;25:359-370.
46. Nishizawa S, Leyton M, Okazawa H, et al. Validation of a less invasive method for measurement of serotonin synthesis rate with -[11C]methyl-L- tryptophan. J Cereb Blood Flow Metab. 1998;18:1121-1129.
47. Coccaro EF, Lee R. Cerebrospinal fluid 5-hydroxyindolacetic acid and homovanillic acid: Reciprocal relationships with impulsive aggression in human subjects. J Neural Transm. 2010;117:241-248.
48. Pihl RO, Young SN, Harden P, et al. Acute effect of altered tryptophan levels and alcohol on aggression in normal human males. Psychopharmacology. 1995;119:353-360.
49. Marsh DM, Dougherty DM, Moeller G, et al. Laboratory-measured aggressive behavior of women: Acute tryptophan depletion and augmentation. Neuropsychopharmacology. 2002;26:664-771.
50. Moeller FG, Dougherty DM, Swann AC, et al. Tryptophan depletion and aggressive responding in healthy males. Psychopharmacology. 1996;126:97-103.
51. Bjork JM, Dougherty DM, Moeller FG, et al. Differential behavioral effects of plasma tryptophan depletion and loading in aggressive and nonaggressive men. Neuropsychopharmacology. 2000;22:357-369.
52. Summers CH, Summers TR, Moore MC, et al. Temporal patterns of limbic monoamine and plasma corticosterone response during social stress. Neuroscience. 2003;116:553-563.
53. Summers CH, Korzan WJ, Lukkes JL, et al. Does serotonin influence aggression? Comparing regional activity before and during social interaction. Physiol Biochem Zool. 2005;78:679-694.
54. Van Erp, AMM, Miczek KA. Aggressive behavior, increased accumbal dopamine and decreased cortical serotonin in rats. J Neurosci. 2000;15:9320-9325.
55. Aan het Rot M, Moskowitz DS, Pinard G, et al. Social behavior and mood in everyday life: The effects of tryptophan in quarrelsome individuals. J Psychiatry Neurosci. 2006;31:253-261.
56. Moskowitz DS, Pinard G, Zuroff DC, et al. The effect of tryptophan on social interaction in everyday life: A placebo-controlled study. Neuropsychopharmacology. 2001;25:277-289.
57. Wood RM, Rilling JK, Sanfey AG, et al. Effects of tryptophan depletion on the performance of an iterated prisoner's dilemma game in healthy adults. Neuropsychopharmacology. 2006;31:1075-1084.
58. Larson ET, Summers CH. Serotonin reverses dominant social status. Behav Brain Res. 2001;121:95-102.