Central serotonin activity and aggression: Inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects

American Journal of Psychiatry

Volumn 154, Issue 10, 1997, Pages 1430-1435

  Coccaro, Emil F ^a   Kavoussi, Richard J ^a   Cooper, Thomas B ^a   Hauger, Richard L ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; DEXFENFLURAMINE; PROLACTIN; PSYCHOTROPIC AGENT; SEROTONIN;

ADULT; AGE; AGGRESSION; ARTICLE; CEREBROSPINAL FLUID LEVEL; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PERSONALITY DISORDER; PRIORITY JOURNAL; PROLACTIN BLOOD LEVEL; PROVOCATION TEST; SEX DIFFERENCE; VIOLENCE;

EID: 0030825179     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.10.1430     Document Type: Article

References (40)

1. Coccaro EF, Kavoussi RJ: Neurotransmitter correlates of impulsive aggression, in The Neurobiology of Clinical Aggression. Edited by Stoff DM, Cairns RB. Hillsdale, NJ, Lawrence Erlbaum Associates, 1996, pp 67-85
2. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF: Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1:131-139
3. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982; 139: 741-746
4. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL: Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 1989; 46:587-599
5. Coccaro EF, Gabriel S, Siever LJ: Buspirone challenge: preliminary evidence for a role for central 5-HT-la receptor function in impulsive aggressive behavior in humans. Psychopharmacol Bull 1990; 26:393-405
6. Moss HB, Yao JK, Panzak GL: Serotonergic responsivity and behavioral dimensions in antisocial personality disorder with substance abuse. Biol Psychiatry 1990; 28:325-338
7. Kruesi MJ, Rapoport JL, Hamburger S, Hibbs E, Potter WZ, Lenane M, Brown GL: Cerebrospinal fluid monoamine metabolites, aggression, and impulsivity in disruptive behavior disorders of children and adolescents. Arch Gen Psychiatry 1990; 47:419-426
8. Higley JD, Mehlman PT, Taub DM, Higley SB, Suomi SJ, Linnoila M, Vickers JH: Cerebrospinal fluid monoamine and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch Gen Psychiatry 1992; 49:436-441
9. Limson R, Goldman D, Roy A, Lamparski D, Ravitz B, Adinoff B, Linnoila M: Personality and cerebrospinal fluid monoamine metabolites in alcoholics and controls. Arch Gen Psychiatry 1991; 48:437-441
10. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M: Low CSF 5-HIAA concentrations and severe aggression and impaired impulse control in nonhuman primates. Am J Psychiatry 1994; 151:1485-1491
11. Coccaro EF, Kavoussi RJ, Hauger RL: Physiologic responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. Int Clin Psychopharmacol 1995; 10:177-180
12. Coccaro EF, Kavoussi RJ, Berman ME, Hauger RL: Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality disordered males. Biol Psychiatry 1996; 40:157-164
13. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK: Low cerebrospinal fluid 5-hydroxyindolacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sei 1983; 33:2609-2614
14. Virkkunen M, Nuutila A, Goodwin FK, Linnoila M: Cerebrospinal fluid metabolite levels in male arsonists. Arch Gen Psychiatry 1987; 44:241-247
15. Lopez-Ibor JJ, Lana F, Saiz Ruiz J: Conductas autoliticas impulsivas y serotonina. Actas Luso Esp Neurol Psiquiatr 1990; 18: 316-325
16. O'Keane V, Moloney E, O'Neill H, O'Connor A, Smith C, Dinan TG: Blunted prolactin responses to d-fenfluramine in sociopathy: evidence for subsensitivity of central Serotonergic function. Br J Psychiatry 1992; 160:643-646
17. BotchinMB, Kaplan JR, Manuck SB, Mann JJ: Low versus high prolactin responders to fenfluramine challenge: marker of behavioral differences in adult male cynomolgus macaques. Neuropsychopharmacology 1993; 9:93-99
18. Virkkunen M, Rawlings R, Tokola R, Poland RE, Guidotti A, Nemeroff C, Bissette G, Kalogeras K, Karonen SL, Linnoila M: CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic, violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry 1994; 51:20-27
19. Keys RC, Botchin MB, Kaplan JR, Manuck SB, Mann JJ: Aggression and brain serotonergic responsivity: response to slides in male macaques. Physiol Behav 1995; 57:205-208
20. Gardner DL, Lucas PB, Cowdry RW: CSF metabolites in borderline personality disorder compared with normal controls. Biol Psychiatry 1990; 28:247-254
21. Coccaro EF: Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavioral relationship. Int Clin Psychopharmacol 1992; 7:3-12
22. Castellanos FX, Elia J, Kruesi MJ, Culotta CS, Mefford IN, Potter WZ, Ritchie GF, Rapoport JL: Cerebrospinal fluid monoamine metabolites in boys with attention-deficit hyperactivity disorder. Psychiatry Res 1994; 52:305-316
23. Moller SE, Mortensen EL, Breum L, Ailing C, Larsen OG, BogeRasmussen T, Jensen C, Bennicke K: Aggression and personality: association with amino acids and monoamine metabolites. Psychol Med 1996; 26:323-331
24. Fishbein DH, Lozovsky D, Jaffe JH: Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers. Biol Psychiatry 1989; 25:1049-1066
25. Wetzler S, Kahn RS, Asnis CM, Korn M, van Praag HM: Serotonin receptor sensitivity and aggression. Psychiatry Res 1991; 37:271-279
26. Stoff DM, Pastiempo AP, Yeung JH, Cooper TB, Bridger WH, Rabinovich H: Neuroendocrine responses to challenge with d,lfenfluramine and aggression in disruptive behavior disorders of children and adolescents. Psychiatry Res 1992; 43:263-276
27. Halperin JM, Sharma V, Siever LJ, Schwartz ST, Matier K, Wornell G, Newcorn JH: Serotonergic function in aggressive and nonaggressive boys with attention deficit hyperactivity disorder. Am J Psychiatry 1994; 151:243-248
28. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo M, Mieczkowski T, Meyers JE, Stanley M: The relationship between central and peripheral serotonin indices in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 1992; 49: 442-446
29. Leckman JF, Sholomskas D, Thompson WD, Belanger A, Weiss-man MM: Best estimate of lifetime psychiatric diagnosis: a méthodologie study. Arch Gen Psychiatry 1982; 39:879-883
30. Klein DN, Ouimette PC, Kelly HS, Ferro T, Riso LP: Test-retest reliability of team consensus best-estimate diagnoses of axis I and II disorders in a family study. Am J Psychiatry 1994; 151: 1043-1047
31. Spitzer RL, Endicott J: Schedule for Affective Disorders and Schizophrenia (SADS), 3rd ed. New York, New York State Psychiatric Institute, Biometrics Research, 1978
32. Pfohl B, Blum N, Zimmerman M, Stangl D: Structured Interview for the DSM-III-R Personality Disorders, Revised (SIDP-R). Iowa City, University of Iowa College of Medicine, Department of Psychiatry, 1989
33. Fri C-G, Wiesel F-A, Sedvall G: Simultaneous quantification of homovanillic acid and 5-hydroxyindolacetic acid in cérébrospinal fluid by mass fragmentography. Life Sei 1974; 14:2469-2480
34. Coccaro EF, Kavoussi RJ, Sheline YI, Lish JD, Csernansky JG: Impulsive aggression in personality disorder: correlates with 3Hparoxetine binding in the platelet. Arch Gen Psychiatry 1996; 53:531-536
35. Guy W (ed): ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338. Washington, DC, US Department of Health, Education, and Welfare, 1976
36. Williams EJ: The comparison of regression variables. J R Statistical Soc (Series B) 1959; 21:396-399
37. Steiger JH: Tests for comparing elements of a correlation matrix. Psychol Bull 1980; 87:245-251
38. Bernstein DP, Handelsman L: The neurobiology of substance abuse and personality disorders, in Neuropsychiatry of Personality Disorders. Edited by Ratey JJ. Cambridge, Mass, Blackwell Science, 1995, pp 120-148
39. Agren H, Mefford IN, Rudorfer MV, Linnoila M, Potter WZ: Interacting neurotransmitter systems: a non-experimental approach to the 5-HIAA-HVA correlation in human CSF. J Psychiatr Res 1986; 20:175-193
40. Mann JJ, Malone KM: Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biol Psychiatry 1997; 41:162-171