Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Zhou, Weisong ^a   Dowell, Dustin R ^a   Huckabee, Matthew M ^a   Newcomb, Dawn C ^a   Boswell, Madison G ^a   Goleniewska, Kasia ^a   Lotz, Matthew T ^a   Toki, Shinji ^a   Yin, Huiyong ^a   Yao, Songyi ^a   Natarajan, Chandramohan ^a   Wu, Pingsheng ^a   Sriram, Subramaniam ^a   Breyer, Richard M ^a   FitzGerald, Garret A ^b   Peebles, R Stokes ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CICAPROST; GLYCOPROTEIN P 15095; ILOPROST; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 23; L SELECTIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PROSTACYCLIN RECEPTOR; ANTINEOPLASTIC AGENT; ANTITHROMBOCYTIC AGENT; DRUG DERIVATIVE; IL17A PROTEIN, MOUSE; PROSTACYCLIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TH17 CELL; TREATMENT RESPONSE; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; MOUSE MUTANT; PATHOLOGY; SPINAL CORD;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELLS, CULTURED; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPOPROSTENOL; FEMALE; HUMANS; ILOPROST; INTERLEUKIN-12; INTERLEUKIN-17; INTERLEUKIN-23; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; PLATELET AGGREGATION INHIBITORS; RECEPTORS, EPOPROSTENOL; SPINAL CORD; TH17 CELLS;

EID: 84861011419     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033518     Document Type: Article

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