Methylglyoxal mediates adipocyte proliferation by increasing phosphorylation of Akt1

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Jia, Xuming ^a   Chang, Tuanjie ^a   Wilson, Thomas W ^a   Wu, Lingyun ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b LAKEHEAD UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AKT1 PROTEIN; ALAGEBRIUM; CYCLIN DEPENDENT KINASE 2; METHYLGLYOXAL; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; PROTEIN P21; PROTEIN P27; SH 6; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; AKT1 PROTEIN, RAT; CELL CYCLE PROTEIN; GLUTATHIONE; LACTOYLGLUTATHIONE LYASE;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; OBESITY; RAT; ANIMAL; CYTOLOGY; DRUG EFFECT; LIPID METABOLISM; METABOLIC SYNDROME X; METABOLISM; MOUSE; PATHOLOGY; PHOSPHORYLATION; ZUCKER RAT;

RATTUS;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL CYCLE PROTEINS; CELL PROLIFERATION; GLUTATHIONE; LACTOYLGLUTATHIONE LYASE; LIPID METABOLISM; MALE; METABOLIC SYNDROME X; MICE; OBESITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVALDEHYDE; RATS; RATS, ZUCKER;

EID: 84861004703     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036610     Document Type: Article

References (48)

1. Monnier VM, Stevens VJ, Cerami A, (1981) Maillard reactions involving proteins and carbohydrates in vivo: relevance to diabetes mellitus and aging. Prog Food Nutr Sci 5: 315-327.
2. Beisswenger BG, Delucia EM, Lapoint N, Sanford RJ, Beisswenger PJ, (2005) Ketosis leads to increased methylglyoxal production on the Atkins diet. Ann N Y Acad Sci 1043: 201-210.
3. Reichard GA Jr, Skutches CL, Hoeldtke RD, Owen OE, (1986) Acetone metabolism in humans during diabetic ketoacidosis. Diabetes 35: 668-674.
4. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, et al. (2007) Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion. Diabetes.
5. Chang T, Wang R, Wu L, (2005) Methylglyoxal-induced nitric oxide and peroxynitrite production in vascular smooth muscle cells. Free Radic Biol Med 38: 286-293.
6. Chang T, Wu L, (2006) Methylglyoxal, oxidative stress, and hypertension. Can J Physiol Pharmacol 84: 1229-1238.
7. Wang H, Liu J, Wu L, (2009) Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells. Biochem Pharmacol 77: 1709-1716.
8. Riboulet-Chavey A, Pierron A, Durand I, Murdaca J, Giudicelli J, et al. (2006) Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes 55: 1289-1299.
9. Shamsi FA, Partal A, Sady C, Glomb MA, Nagaraj RH, (1998) Immunological evidence for methylglyoxal-derived modifications in vivo. Determination of antigenic epitopes. J Biol Chem 273: 6928-6936.
10. Beisswenger PJ, Drummond KS, Nelson RG, Howell SK, Szwergold BS, et al. (2005) Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes 54: 3274-3281.
11. Wang X, Desai K, Clausen JT, Wu L, (2004) Increased methylglyoxal and advanced glycation end products in kidney from spontaneously hypertensive rats. Kidney Int 66: 2315-2321.
12. Wang H, Meng QH, Gordon JR, Khandwala H, Wu L, (2007) Proinflammatory and proapoptotic effects of methylglyoxal on neutrophils from patients with type 2 diabetes mellitus. Clin Biochem 40: 1232-1239.
13. Wu L, Juurlink BH, (2002) Increased methylglyoxal and oxidative stress in hypertensive rat vascular smooth muscle cells. Hypertension 39: 809-814.
14. Vasdev S, Ford CA, Longerich L, Parai S, Gadag V, et al. (1998) Aldehyde induced hypertension in rats: prevention by N-acetyl cysteine. Artery 23: 10-36.
15. Watson AM, Soro-Paavonen A, Sheehy K, Li J, Calkin AC, et al. (2011) Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 54: 681-689.
16. Thomas MC, Baynes JW, Thorpe SR, Cooper ME, (2005) The role of AGEs and AGE inhibitors in diabetic cardiovascular disease. Curr Drug Targets 6: 453-474.
17. Hausman DB, DiGirolamo M, Bartness TJ, Hausman GJ, Martin RJ, (2001) The biology of white adipocyte proliferation. Obes Rev 2: 239-254.
18. Gregoire FM, (2001) Adipocyte differentiation: from fibroblast to endocrine cell. Exp Biol Med (Maywood) 226: 997-1002.
19. Ebbeling CB, Pawlak DB, Ludwig DS, (2002) Childhood obesity: public-health crisis, common sense cure. Lancet 360: 473-482.
20. Hager A, Sjostrm L, Arvidsson B, Bjorntorp P, Smith U, (1977) Body fat and adipose tissue cellularity in infants: a longitudinal study. Metabolism 26: 607-614.
21. Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH, (2007) Hyperglycemia Enhances Adipogenic Induction of Lipid Accumulation: Involvement of Extracellular Signal-Regulated Protein Kinase 1/2, Phosphoinositide 3-Kinase/Akt, and Peroxisome Proliferator-Activated Receptor {gamma} Signaling. Endocrinology 148: 4267-4275.
22. Menghini R, Marchetti V, Cardellini M, Hribal ML, Mauriello A, et al. (2005) Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 111: 1946-1953.
23. Rosen ED, Walkey CJ, Puigserver P, Spiegelman BM, (2000) Transcriptional regulation of adipogenesis. Genes Dev 14: 1293-1307.
24. Fajas L, Fruchart JC, Auwerx J, (1998) Transcriptional control of adipogenesis. Curr Opin Cell Biol 10: 165-173.
25. Graff JR, Konicek BW, McNulty AM, Wang Z, Houck K, et al. (2000) Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression. J Biol Chem 275: 24500-24505.
26. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, et al. (2001) Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3: 245-252.
27. Naaz A, Holsberger DR, Iwamoto GA, Nelson A, Kiyokawa H, et al. (2004) Loss of cyclin-dependent kinase inhibitors produces adipocyte hyperplasia and obesity. Faseb J 18: 1925-1927.
28. Peng XD, Xu PZ, Chen ML, Hahn-Windgassen A, Skeen J, et al. (2003) Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes Dev 17: 1352-1365.
29. Bhattacharya I, Ullrich A, (2006) Endothelin-1 inhibits adipogenesis: role of phosphorylation of Akt and ERK1/2. FEBS Lett 580: 5765-5771.
30. Cantero AV, Portero-Otin M, Ayala V, Auge N, Sanson M, et al. (2007) Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis. Faseb J 21: 3096-3106.
31. Ota K, Nakamura J, Li W, Kozakae M, Watarai A, et al. (2007) Metformin prevents methylglyoxal-induced apoptosis of mouse Schwann cells. Biochem Biophys Res Commun 357: 270-275.
32. Kani S, Nakayama E, Yoda A, Onishi N, Sougawa N, et al. (2007) Chk2 kinase is required for methylglyoxal-induced G2/M cell-cycle checkpoint arrest: implication of cell-cycle checkpoint regulation in diabetic oxidative stress signaling. Genes Cells 12: 919-928.
33. Jia X, Wu L, (2007) Accumulation of endogenous methylglyoxal impaired insulin signaling in adipose tissue of fructose-fed rats. Mol Cell Biochem 306: 133-139.
34. Green H, Kehinde O, (1975) An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5: 19-27.
35. Kilhovd BK, Giardino I, Torjesen PA, Birkeland KI, Berg TJ, et al. (2003) Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes. Metabolism 52: 163-167.
36. Beisswenger PJ, Howell SK, Touchette AD, Lal S, Szwergold BS, (1999) Metformin reduces systemic methylglyoxal levels in type 2 diabetes. Diabetes 48: 198-202.
37. Wang X, Jia X, Chang T, Desai K, Wu L, (2008) Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats. J Hypertens 26: 765-772.
38. Wang X, Chang T, Jiang B, Desai K, Wu L, (2007) Attenuation of hypertension development by aminoguanidine in spontaneously hypertensive rats: role of methylglyoxal. Am J Hypertens 20: 629-636.
39. Chang KC, Paek KS, Kim HJ, Lee YS, Yabe-Nishimura C, et al. (2002) Substrate-induced up-regulation of aldose reductase by methylglyoxal, a reactive oxoaldehyde elevated in diabetes. Mol Pharmacol 61: 1184-1191.
40. Wu L, Yang W, Jia X, Yang G, Duridanova D, et al. (2009) Pancreatic islet overproduction of H2S and suppressed insulin release in Zucker diabetic rats. Lab Invest 89: 59-67.
41. Nagaraj RH, Sarkar P, Mally A, Biemel KM, Lederer MO, et al. (2002) Effect of pyridoxamine on chemical modification of proteins by carbonyls in diabetic rats: characterization of a major product from the reaction of pyridoxamine and methylglyoxal. Arch Biochem Biophys 402: 110-119.
42. Chang T, Wang R, Olson DJ, Mousseau DD, Ross AR, et al. (2011) Modification of Akt1 by methylglyoxal promotes the proliferation of vascular smooth muscle cells. FASEB J 25: 1746-1757.
43. Liu J, Wang R, Desai K, Wu L, (2011) Upregulation of aldolase B and overproduction of methylglyoxal in vascular tissues from rats with metabolic syndrome. Cardiovascular research 92: 494-503.
44. Kim JB, Song BW, Park S, Hwang KC, Cha BS, et al. (2010) Alagebrium chloride, a novel advanced glycation end-product cross linkage breaker, inhibits neointimal proliferation in a diabetic rat carotid balloon injury model. Korean Circ J 40: 520-526.
45. Brady MJ, Kartha PM, Aysola AA, Saltiel AR, (1999) The role of glucose metabolites in the activation and translocation of glycogen synthase by insulin in 3T3-L1 adipocytes. J Biol Chem 274: 27497-27504.
46. Chaplen FW, Fahl WE, Cameron DC, (1996) Detection of methylglyoxal as a degradation product of DNA and nucleic acid components treated with strong acid. Anal Biochem 236: 262-269.
47. Wu L, Eftekharpour E, Davies GF, Roesler WJ, Juurlink BH, (2001) Troglitazone selectively inhibits glyoxalase I gene expression. Diabetologia 44: 2004-2012.
48. Jia X, Olson DJ, Ross AR, Wu L, (2006) Structural and functional changes in human insulin induced by methylglyoxal. Faseb J 20: 1555-1557.