Transcriptional changes in OXPHOS complex I deficiency are related to anti-oxidant pathways and could explain the disturbed calcium homeostasis

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 7, 2012, Pages 1161-1168

  Voets, A M ^a   Huigsloot, M ^b   Lindsey, P J ^a   Leenders, A M ^b   Koopman, W J H ^c   Willems, P H G M ^c   Rodenburg, R J ^b   Smeitink, J A M ^b   Smeets, H J M ^a,d  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Complex I deficiency; Gene expression; Mitochondrion; Nrf2; Oxidative stress; Selenoprotein

Indexed keywords

CALCIUM; DNA; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SELENIUM; SELENOPROTEIN; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CALCIUM HOMEOSTASIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; FEMALE; FIBROBLAST; GENE EXPRESSION PROFILING; HUMAN; INFANT; MALE; OXIDATIVE STRESS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIOXIDANTS; CALCIUM; CELL CYCLE PROTEINS; CHILD, PRESCHOOL; DNA DAMAGE; ELECTRON TRANSPORT COMPLEX I; ENDOPLASMIC RETICULUM STRESS; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; GLUTATHIONE; HOMEOSTASIS; HUMANS; INFANT; INFANT, NEWBORN; MALE; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIAL DISEASES; NF-E2-RELATED FACTOR 2; NUCLEAR PROTEINS; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; SELENOPROTEINS;

EID: 84860887855     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.10.009     Document Type: Article

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