Comparison of the effects of clozapine, chlorpromazine, and haloperidol on membrane lateral heterogeneity

Chemistry and Physics of Lipids

Volumn 112, Issue 2, 2001, Pages 151-163

  Jutila, Arimatti ^a   Söderlund, Tim ^a   Pakkanen, Antti L ^a   Huttunen, Matti ^a   Kinnunen, Paavo K J ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Drug lipid interactions; Fluorescence microscopy; Membrane organization; Monolayer; Neuroleptics

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; HALOPERIDOL; PHOSPHATIDYLSERINE; PHOSPHOLIPID;

ARTICLE; BRAIN; DRUG BINDING; DRUG EFFECT; DRUG PENETRATION; FLUORESCENCE MICROSCOPY; HYDROPHOBICITY; MORPHOLOGY; PHASE SEPARATION; PRIORITY JOURNAL; TEMPERATURE;

ANTIPSYCHOTIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHLORPROMAZINE; CLOZAPINE; HALOPERIDOL; LIPOSOMES; MEMBRANE LIPIDS; MEMBRANES, ARTIFICIAL; MICROSCOPY, FLUORESCENCE;

EID: 0034873514     PISSN: 00093084     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-3084(01)00175-X     Document Type: Article

References (48)

1. Structure and functions of channel-forming peptides: Magainins, cecropins, mellitin and alamethicin
2. Lipid intermolecular hydrogen bonding: Influence on structural organization and membrane function
3. How do the polyene macrolide antibiotics affect the cellular membrane properties?
4. Brain cortex phosphatidylserine inhibits phosphatidylinositol turnover in rat anterior pituitary glands
5. Dipole potential of lipid membranes
6. Lipid monolayers: Why use half a membrane to characterize protein-membrane interactions?
7. 2 activity
8. Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and α1-adrenergic receptors in vitro
9. Lateral pressures in cell membranes: A mechanism for modulation of protein function
10. Antioxidant properties of clozapine and related neuroleptics
11. Monolayer characteristics and thermal behaviour of natural and synthetic phosphatidylserines
12. Adriamycin inactivates cytochrome c oxidase by exclusion of the enzyme from its cardiolipin essential environment
13. Influence of cationic amphiphilic drugs on the phase-transition temperature of phospholipids with different polar headgroups
14. 3H]glycerol in the primordial human placenta
15. The membrane hypothesis in schizophrenia
16. Detachment of cytochrome c by cationic drugs from membranes containing acidic phospholipids: Comparison of lidocaine, propranolol, and gentamycin
17. Structure and phase transitions in Langmuir monolayers
18. Disorders of thought: Schizophrenia
19. On the principles of functional ordering in biological membranes
20. Lipid bilayers as osmotic response elements
21. Altered microviscosity at brain membrane surface induces distinct and reversible inhibition of opioid receptor binding
22. Effects of chlorpromazine and other phenothiazine derivatives on the permeability of liposomes
23. Structures and transitions in lipid monolayers at the air-water interface
24. Role of lipid organization and dynamics for membrane functionality
25. The influence of anesthetics and cholesterol on the degree of molecular organization and mobility of ox brain white matter. Lipids in multibilayer membranes: A spin probe study using spectral simulation ny the stochastic method
26. Critical phenomena: Fluctuations caught in the act
27. Partitioning and membrane disordering effects of dopamine antagonists: Influence of lipid peroxidation, temperature, and drug concentration
28. Molecular insights into schizophrenia
29. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity
30. 2 prefrontal cortex receptors
31. The membrane lipid environment modulates drug interactions with the p-glycoprotein multidrug transporter
32. Interactions of chlorpromazine and imipramine with artificial membranes investigated by equilibrium dialysis, dual-wavelength photometry, and fluorimetry
33. Partition of dopamine antagonists into synthetic lipid bilayers: The effect of membrane structure and composition
34. Lipid peroxidation as a possible mechanism for the neurotoxic and nephrotoxic effects of a combination of lithium carbonate and haloperidol
35. Modulation of phosphatidylserine homeostasis by amphiphilic cations in a human neuronal cell line, LA-N-2
36. Cholesterol's interfacial interaction with sphingomyelins and phosphatidylcholines: Hydrocarbon chain structure determines the magnitude of condensation
37. Relationship between plasma concentrations of clozapine and norclozapine and therapeutic response in patients with schizophrenia resistant to conventional neuroleptics
38. 2 receptor binding activities by specific lipids
39. Binding and dissociation of cytochrome c to and from membranes containing acidic phospholipids
40. Omega 3 fatty acids in bipolar disorder. A preliminary double-blinded, placebo-controlled trial
41. Effect of chlorpromazine on the synthesis, hydrolysis, and transfer of microsomal cytidine liponucelotides and mitochondrial polyglycerophosphatides
42. Interactions of cyclosporin A with phospholipid membranes: Effect of cholesterol
43. Binding of adriamycin to liposomes as a probe for membrane lateral organization
44. The deficit syndrome of schizophrenia: Towards heterogeneity
45. Cholesterol stabilizes the crystal-liquid interface in phospholipid monolayers