Inflammatory bowel disease in veterinary medicine

Frontiers in Bioscience - Elite

Volumn 4 E, Issue 4, 2012, Pages 1404-1419

  Jergens, Albert E ^a   Simpson, Kenneth W ^b  

^a IOWA STATE UNIVERSITY   (United States)

^b Animal Health Diagnostic Center   (United States)

Author keywords

Animal model; Biomarkers; Cats; Dogs; E. coli; Histiocytic ulcerative colitis; IBD; Probiotic; Review

Indexed keywords

AZATHIOPRINE; METRONIDAZOLE; PREBIOTIC AGENT; PREDNISOLONE; PROBIOTIC AGENT; SALAZOSULFAPYRIDINE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; ANTIINFLAMMATORY AGENT;

ARTICLE; COLON; CRYPTOSPORIDIUM; DIARRHEA; DIET THERAPY; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE SEVERITY; ENDOSCOPY; ENTERITIS; FECES ANALYSIS; GIARDIA; HEMATOLOGY; HISTOPATHOLOGY; HISTOPLASMA; INNATE IMMUNITY; INTESTINE FLORA; MYCOBACTERIUM; NONHUMAN; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PROTOTHECOSIS; PYTHIOSIS; SEROLOGY; SMALL INTESTINE; STOMACH; T LYMPHOCYTE; TOXOPLASMA; TRITRICHOMONAS FOETUS; VETERINARY MEDICINE; VOMITING; WEIGHT REDUCTION; ANIMAL; ANIMAL DISEASE; CAT; DIET; DOG; REVIEW;

ANIMALIA; CANIS FAMILIARIS; ENTEROBACTERIACEAE; FELIDAE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CATS; DIAGNOSIS, DIFFERENTIAL; DIET; DOGS; INFLAMMATORY BOWEL DISEASES; PROBIOTICS;

EID: 84860857259     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e470     Document Type: Article

References (123)

1. A. J. German, E. J. Hall and M. J. Day: Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med 15, 14-25 (2001) (Pubitemid 33722486)
2. A. E. Jergens, F. M. Moore, J. S. Haynes and K. G. Miles: Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987-1990). J Am Vet Med Assoc 201, 1603-1608 (1992)
3. A. E. Jergens, F. M. Moore, M. S. Kaiser, J. S. Haynes and J. M. Kinyon: Morphometric evaluation of immunoglobulin A-containing and immunoglobulin Gcontaining cells and T cells in duodenal mucosa from healthy dogs and from dogs with inflammatory bowel disease or nonspecific gastroenteritis. Am J Vet Res 57, 697-704 (1996) (Pubitemid 126613627)
4. K. Allenspach, B. Wieland, A. Grone and F. Gaschen: Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med 21 700-708 (2007) (Pubitemid 47228251)
5. M. Craven, J. W. Simpson, A. E. Ridyard and M. L. Chandler: Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J Small Anim Pract 45, 336-342 (2004) (Pubitemid 38918658)
6. W. G. Guilford, B. R. Jones, P. J. Markwell, D. G. Arthur, M. G. Collett and J. G. Harte: Food sensitivity in cats with chronic idiopathic gastrointestinal problems. J Vet Intern Med 15, 7-13 (2001) (Pubitemid 33722485)
7. A. E. Jergens: Inflammatory bowel disease. Current perspectives. Vet Clin North Am Small Anim Pract 29, 501-521, vii (1999) (Pubitemid 29160145)
8. N. Luckschander, K. Allenspach, J. Hall, F. Seibold, A. Grne, M. Doherr and F. Gaschen: Perinuclear antineutrophilic cytoplasmic antibody and response to treatment in diarrheic dogs with food responsive disease or inflammatory bowel disease. J Vet Intern Med 20, 221-227 (2006)
9. A. J. German, E. J. Hall, D. F. Kelly, A. D. Watson and M. J. Day: An immunohistochemical study of histiocytic ulcerative colitis in boxer dogs. J Comp Pathol 122, 163-175 (2000) (Pubitemid 30301555)
10. M. S. Leib, D. P. Sponenberg, J. R. Wilcke and A. S. Loar: Suppurative colitis in a cat. J Am Vet Med Assoc 188, 739-741 (1986) (Pubitemid 16103454)
11. R. B. Sartor: Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 3, 390-407 (2006) (Pubitemid 44018812)
12. R. J. Xavier and D. K. Podolsky: Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434 (2007) (Pubitemid 47123518)
13. R. Duerr, K. Taylor, S. Brant, J. Rioux, M. Silverberg, M. Daly, A. H. Steinhart, C. Abraham, M. Regueiro, A. Griffiths, T. Dassopoulos, A. Bitton, H. Yang, S. Targan, L. Datta, E. Kistner, L. P. Schumm, A. Lee, P. Gregersen, M. M. Barmada, J. Rotter, D. Nicolae and J. Cho: A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314, 1461-1463 (2006) (Pubitemid 44871953)
14. P. Goyette, C. Labb, T. Trinh, R. Xavier and J. Rioux: Molecular pathogenesis of inflammatory bowel disease: genotypes, phenotypes and personalized medicine. Ann Med 39, 177-199 (2007) (Pubitemid 46676480)
15. J. Hampe, A. Franke, P. Rosenstiel, A. Till, M. Teuber, K. Huse, M. Albrecht, G. Mayr, F. De La Vega, J. Briggs, S. Gnther, N. Prescott, C. Onnie, R. Hsler, B. Sipos, U. Flsch, T. Lengauer, M. Platzer, C. Mathew, M. Krawczak and S. Schreiber: A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39, 207-211 (2007) (Pubitemid 46184351)
16. C. Libioulle, E. Louis, S. Hansoul, C. Sandor, F. Farnir, D. Franchimont, S. Vermeire, O. Dewit, M. de Vos, A. Dixon, B. Demarche, I. Gut, S. Heath, M. Foglio, L. Liang, D. Laukens, M. Mni, D. Zelenika, A. Van Gossum, P. Rutgeerts, J. Belaiche, M. Lathrop and M. Georges: Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 3, e58-e58 (2007)
17. V. Peltekova, R. Wintle, L. Rubin, C. Amos, Q. Huang, X. Gu, B. Newman, M. Van Oene, D. Cescon, G. Greenberg, A. Griffiths, P. St George-Hyslop and K. Siminovitch: Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat Genet 36, 471-475 (2004) (Pubitemid 38620030)
18. E. B. Breitschwerdt: Immunoproliferative enteropathy of basenjis. Semin Vet Med Surg (Small Anim) 7, 153-161 (1992)
19. R. K. Churcher and A. D. Watson: Canine histiocytic ulcerative colitis. Aust Vet J 75, 710-713 (1997)
20. R. Hostutler, B. Luria, S. Johnson, S. Weisbrode, R. Sherding, J. Jaeger and W. G. Guilford: Antibioticresponsive histiocytic ulcerative colitis in 9 dogs. J Vet Intern Med 18, 499-504 (2004) (Pubitemid 39107538)
21. M. P. Littman, D. M. Dambach, S. L. Vaden and U. Giger: Familial protein-losing enteropathy and proteinlosing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997). J Vet Intern Med 14, 68-80 (2000)
22. C. S. Mansfield, F. E. James, M. Craven, D. R. Davies, A. J. O'Hara, P. K. Nicholls, B. Dogan, S. P. MacDonough and K. W. Simpson: Remission of histiocytic ulcerative colitis in Boxer dogs correlates with eradication of invasive intramucosal Escherichia coli. J Vet Intern Med 23, 964-969 (2009)
23. M. Baumgart, B. Dogan, M. Rishniw, G. Weitzman, B. Bosworth, R. Yantiss, R. H. Orsi, M. Wiedmann, P. McDonough, S. G. Kim, D. Berg, Y. Schukken, E. Scherl and K. W. Simpson: Culture independent analysis of ileal mucosa reveals a selective increase in invasive Escherichia coli of novel phylogeny relative to depletion of Clostridiales in Crohn's disease involving the ileum. ISME J 1, 403-418 (2007) (Pubitemid 47373247)
24. K. W. Simpson, B. Dogan, M. Rishniw, R. E. Goldstein, S. Klaessig, P. L. McDonough, A. J. German, R. M. Yates, D. G. Russell, S. E. Johnson, D. E. Berg, J. Harel, G. Bruant, S. P. McDonough and Y. H. Schukken: Adherent and invasive Escherichia coli is associated with granulomatous colitis in boxer dogs. Infect Immun 74, 4778-4792 (2006) (Pubitemid 44157265)
25. A. Darfeuille-Michaud, J. Boudeau, P. Bulois, C. Neut, A. L. Glasser, N. Barnich, M. A. Bringer, A. Swidsinski, L. Beaugerie and J. F. Colombel: High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology 127, 412-21 (2004) (Pubitemid 39091889)
26. A. Darfeuille-Michaud, C. Neut, N. Barnich, E. Lederman, P. Di Martino, P. Desreumaux, L. Gambiez, B. Joly, A. Cortot and J. F. Colombel: Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 115, 1405-1413 (1998) (Pubitemid 28545991)
27. D. N. Frank, A. L. St Amand, R. A. Feldman, E. C. Boedeker, N. Harpaz and N. R. Pace: Molecularphylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104, 13780-137805 (2007)
28. M. Martinez-Medina, X. Aldeguer, M. Lopez-Siles, F. Gonzlez-Huix, C. Lpez-Oliu, G. Dahbi, J. Blanco, J. Blanco, L. J. Garcia-Gil and A. Darfeuille-Michaud: Molecular diversity of Escherichia coli in the human gut: new ecological evidence supporting the role of adherentinvasive E. coli (AIEC) in Crohn's disease. Inflamm Bowel Dis 15, 872-882 (2009)
29. N. Barnich, F. A. Carvalho, A. L. Glasser, C. Darcha, P. Jantscheff, M. Allez, H. Peeters, G. Bommelaer, P. Desreumaux, J. F. Colombel and A. Darfeuille-Michaud: CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest 117, 1566-1574 (2007) (Pubitemid 46871341)
30. M.-A. Bringer, A.-L. Glasser, C.-H. Tung, S. Mresse and A. Darfeuille-Michaud: The Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 replicates in mature phagolysosomes within J774 macrophages. Cell Microbiol 8, 471-484 (2006) (Pubitemid 43356036)
31. P. Lapaquette, A.-L. Glasser, A. Huett, R. Xavier and A. Darfeuille-Michaud: Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 12, 99-113 (2010)
32. S. Meconi, A. Vercellone, F. Levillain, B. Payr, T. Al Saati, F. Capilla, P. Desreumaux, A. Darfeuille-Michaud and F. Altare: Adherent-invasive Escherichia coli isolated from Crohn's disease patients induce granulomas in vitro. Cell Microbiol 9, 1252-1261 (2007) (Pubitemid 46547142)
33. L.-H. Perez, M. Butler, T. Creasey, J. Dzink-Fox, J. Gounarides, S. Petit, A. Ropenga, N. Ryder, K. Smith, P. Smith and S. Parkinson: Direct bacterial killing in vitro by recombinant Nod2 is compromised by Crohn's diseaseassociated mutations. PloS One 5, e10915-e10915 (2010)
34. R. M. Batt, J. R. Needham and M. W. Carter: Bacterial overgrowth associated with a naturally occurring enteropathy in the German shepherd dog. Res Vet Sci 35, 42-46 (1983)
35. R. M. Littler, R. M. Batt and D. H. Lloyd: Total and relative deficiency of gut mucosal IgA in German shepherd dogs demonstrated by faecal analysis. Vet Rec 158, 334-341 (2006)
36. K. Allenspach, A. House, K. Smith, F. M. McNeill, A. Hendricks, J. Elson-Riggins, A. Riddle, J. M. Steiner, D. Werling, O. A. Garden, B. Catchpole and J. S. Suchodolski: Evaluation of mucosal bacteria and histopathology, clinical disease activity and expression of Toll-like receptors in German shepherd dogs with chronic enteropathies. Vet Microbiol 146,326-335 (2010)
37. A. Kathrani, A. House, B. Catchpole, A. Murphy, A. German, D. Werling and K. Allenspach: Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs. PloS One 5, e15740-e15740 (2010)
38. I. A. Burgener, A. Knig, K. Allenspach, S. N. Sauter, J. Boisclair, M. G. Doherr and T. W. Jungi: Upregulation of toll-like receptors in chronic enteropathies in dogs. J Vet Intern Med 22, 553-560 (2008)
39. L. A. McMahon, A. K. House, B. Catchpole, J. Elson-Riggins, A. Riddle, K. Smith, D. Werling, I. A. Burgener and K. Allenspach: Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease. Vet Immunol Immunopathol 135 158-163 (2010)
40. I. Atreya, R. Atreya and M. F. Neurath: NF-kappaB in inflammatory bowel disease. J Vet Intern Med 263 591-596 (2008)
41. C. Abraham and J. Cho: Interleukin-23/Th17 pathways and inflammatory bowel disease. Inflamm Bowel Dis 15, 1090-1100 (2009)
42. N. Luckschander, J. Hall, F. Gaschen, U. Forster, N. Wenzlow, P. Hermann, K. Allenspach, D. Dobbelaere, I. Burgener and M. Welle: Activation of nuclear factorkappaB in dogs with chronic enteropathies. Vet Immunol Immunopathol 133, 228-236 (2010)
43. J. Dandrieux, V. Bornand, M. Doherr, R. Kano, A. Zurbriggen and I. Burgener: Evaluation of lymphocyte apoptosis in dogs with inflammatory bowel disease. Am J Vet Res 69, 1279-1285 (2008)
44. A. J. German, E. J. Hall and M. J. Day: Immune cell populations within the duodenal mucosa of dogs with enteropathies. J Vet Intern Med 15, 14-25 (2001) (Pubitemid 33722486)
45. S. C. Gunawardana, A. E. Jergens, F. A. Ahrens and Y. Niyo: Colonic nitrite and immunoglobulin G concentrations in dogs with inflammatory bowel disease. J Am Vet Med Assoc 211, 318-321 (1997) (Pubitemid 27357495)
46. A. E. Jergens, I. M. Sonea, A. M. O'Connor, L. K. Kauffman, S. D. Grozdanic, M. R. Ackermann and R. B. Evans: Intestinal cytokine mRNA expression in canine inflammatory bowel disease: A meta-analysis with critical appraisal. Comp Med 59, 153-162 (2009)
47. I. Peters, C. Helps, E. Calvert, E. Hall and M. Day: Cytokine mRNA quantification in duodenal mucosa from dogs with chronic enteropathies by real-time reverse transcriptase polymerase chain reaction. J Vet Intern Med 19, 644-653 (2005) (Pubitemid 41452334)
48. J. Stonehewer, J. W. Simpson, R. W. Else and N. Macintyre: Evaluation of B and T lymphocytes and plasma cells in colonic mucosa from healthy dogs and from dogs with inflammatory bowel disease. Res Vet Sci 65, 59-63 (1998) (Pubitemid 128515618)
49. A. J. German, C. R. Helps, E. J. Hall and M. J. Day: Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies. Dig Dis Sci 45, 7-17 (2000) (Pubitemid 30111680)
50. C. Locher, A. Tipold, M. Welle, A. Busato, A. Zurbriggen and M. E. Griot-Wenk: Quantitative assessment of mast cells and expression of IgE protein and mRNA for IgE and interleukin 4 in the gastrointestinal tract of healthy dogs and dogs with inflammatory bowel disease. Am J Vet Res 62, 211-216 (2001) (Pubitemid 33605460)
51. A. Ridyard, T. Nuttall, R. Else, J. Simpson and H. R. P. Miller: Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis. Vet Immunol Immunopathol 86, 205-214 (2002) (Pubitemid 34465750)
52. S. Janeczko, D. Atwater, E. Bogel, A. Greiter-Wilke, A. Gerold, M. Baumgart, H. Bender, P. L. McDonough, S. P. McDonough, R. E. Goldstein and K. W. Simpson: The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease. Vet Microbiol 128, 178-93 (2008) (Pubitemid 351192258)
53. N. Waly, C. Stokes, T. Gruffydd-Jones and M. Day: Immune cell populations in the duodenal mucosa of cats with inflammatory bowel disease. J Vet Intern Med 18, 816-825 (2004) (Pubitemid 40081537)
54. N. N. Van, K. Taglinger, C. R. Helps, S. Tasker, T. J. Gruffydd-Jones and M. J. Day: Measurement of cytokine mRNA expression in intestinal biopsies of cats with inflammatory enteropathy using quantitative real-time RTPCR. Vet Immunol Immunopathol 113, 404-414 (2006) (Pubitemid 44287095)
55. A. E. Jergens, Y. Gamet, F. M. Moore, Y. Niyo, C. Tsao and B. Smith: Colonic lymphocyte and plasma cell populations in dogs with lymphocytic- plasmacytic colitis. Am J Vet Res 60, 515-520 (1999) (Pubitemid 129535505)
56. N. M. S. Schreiner, F. Gaschen, A. Grne, S. N. Sauter and K. Allenspach: Clinical signs, histology, and CD3- positive cells before and after treatment of dogs with chronic enteropathies. J Vet Intern Med 22, 1079-1083 (2008)
57. A. Jergens, I. Sonea, A. O'Connor, L. Kauffman, S. Grozdanic, M. Ackermann and R. Evans: Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal. Comp Med 59 153-162 (2009)
58. D. I. Grove, A. A. Mahmound and K. S. Warren: Suppression of cell-mediated immunity by metronidazole. Int Arch Allergy Appl Immunol 54, 422-427 (1977) (Pubitemid 8135107)
59. E. Westermarck, T. Skrzypczak, J. Harmoinen, J. Steiner, C. Ruaux, D. Williams, E. Eerola, P. Sundbck and M. Rinkinen: Tylosin-responsive chronic diarrhea in dogs. J Vet Intern Med 19, 177-186 (2005) (Pubitemid 40463332)
60. A. Kipar, J. Kremendahl, M. L. Jackson and M. Reinacher: Comparative examination of cats with feline leukemia virus-associated enteritis and other relevant forms of feline enteritis. Vet Pathol 38, 359-371 (2001) (Pubitemid 33654631)
61. J. Suchodolski, P. Xenoulis, C. Paddock, J. Steiner and A. Jergens: Molecular analysis of the bacterial microbiota in duodenal biopsies from dogs with idiopathic inflammatory bowel disease. Vet Microbiol 142, 394-400 (2010)
62. P. Xenoulis, B. Palculict, K. Allenspach, J. Steiner, A. Van House and J. Suchodolski: Molecular-phylogenetic characterization of microbial communities imbalances in the small intestine of dogs with inflammatory bowel disease. FEMS Microbiol Ecol 66, 579-589 (2008)
63. F. Sanchez-Munoz, A. Dominguez-Lopez and J.-K. Yamamoto-Furusho: Role of cytokines in inflammatory bowel disease. World J Gastroenterol 14, 4280-4288 (2008)
64. I. J. Fuss, M. Neurath, M. Boirivant, J. S. Klein, C. de la Motte, S. A. Strong, C. Fiocchi and W. Strober: Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157, 1261-1270 (1996) (Pubitemid 126449643)
65. J. S. Dennis, J. M. Kruger and T. P. Mullaney: Lymphocytic/plasmacytic gastroenteritis in cats: 14 cases (1985-1990). J Am Vet Med Assoc 200, 1712-1718 (1992)
66. J. S. Dennis, J. M. Kruger and T. P. Mullaney: Lymphocytic/plasmacytic colitis in cats: 14 cases (1985-1990). J Am Vet Med Assoc 202, 313-318 (1993)
67. K. W. Simpson, J. Fyfe, A. Cornetta, A. Sachs, D. Strauss-Ayali, S. V. Lamb and T. J. Reimers: Subnormal concentrations of serum cobalamin (vitamin B12) in cats with gastrointestinal disease. J Vet Intern Med 15, 26-32 (2001) (Pubitemid 33722487)
68. D. J. Weiss, J. M. Gagne and P. J. Armstrong: Relationship between inflammatory hepatic disease and inflammatory bowel disease, pancreatitis, and nephritis in cats. J Am Vet Med Assoc 209, 1114-1116 (1996) (Pubitemid 126557319)
69. S. Evans, J. Bonczynski, J. Broussard, E. Han and K. Baer: Comparison of endoscopic and full-thickness biopsy specimens for diagnosis of inflammatory bowel disease and alimentary tract lymphoma in cats. J Am Vet Med Assoc 229, 1447-1450 (2006) (Pubitemid 44672531)
70. S. Kleinschmidt, J. Harder, I. Nolte, S. Marsilio and M. Hewicker-Trautwein: Chronic inflammatory and noninflammatory diseases of the gastrointestinal tract in cats: diagnostic advantages of full-thickness intestinal and extraintestinal biopsies. J Feline Med Surg 12, 97-103 (2010)
71. A. E. Jergens, C. A. Schreiner, D. E. Frank, Y. Niyo, F. E. Ahrens, P. D. Eckersall, T. J. Benson and R. Evans: A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med 17, 291-297 (2003) (Pubitemid 37465328)
72. R. J. Washabau, M. J. Day, M. D. Willard, E. J. Hall, A. E. Jergens, J. Mansell, T. Minami and T. W. Bilzer: Endoscopic, biopsy, and histopathologic guidelines for the evaluation of gastrointestinal inflammation in companion animals. J Vet Intern Med 24, 10-26 (2010)
73. J. Gookin, S. Stauffer and M. Levy: Identification of Pentatrichomonas hominis in feline fecal samples by polymerase chain reaction assay. Vet Parasitol 145, 11-15 (2007) (Pubitemid 46366136)
74. J. Ridgway, A. E. Jergens and Y. Niyo: Possible causal association of idiopathic inflammatory bowel disease with thrombocytopenia in the dog. J Am Anim Hosp Assoc 37, 65-74 (2001) (Pubitemid 32097078)
75. A. Jergens, J. Crandell, R. Evans, M. Ackermann, K. Miles and C. Wang: A clinical index for disease activity in cats with chronic enteropathy. J Vet Intern Med 24, 1027-1033 (2010)
76. S. Bailey, L. Benigni, J. Eastwood, O. A. Garden, L. McMahon, K. Smith, J. M. Steiner, J. S. Suchodolski and K. Allenspach: Comparisons between cats with normal and increased fPLI concentrations in cats diagnosed with inflammatory bowel disease. Journal Small Anim Pract 51, 484-489 (2010)
77. A. Kathrani, J. M. Steiner, J. Suchodolski, J. Eastwood, H. Syme, O. A. Garden and K. Allenspach: Elevated canine pancreatic lipase immunoreactivity concentration in dogs with inflammatory bowel disease is associated with a negative outcome. Journal Small Anim Pract, 50, 126-132 (2009)
78. C. G. Ruaux, J. M. Steiner and D. A. Williams: Early biochemical and clinical responses to cobalamin supplementation in cats with signs of gastrointestinal disease and severe hypocobalaminemia. J Vet Intern Med 19, 155-160 (2005) (Pubitemid 40463329)
79. L. Gaschen, P. Kircher, A. Stssi, K. Allenspach, F. Gaschen, M. Doherr and A. Grne: Comparison of ultrasonographic findings with clinical activity index (CIBDAI) and diagnosis in dogs with chronic enteropathies. Vet Radiol Ultrasound 49, 56-64 (2008)
80. A. L. Zwingenberger, S. L. Marks, T. W. Baker and P. F. Moore: Ultrasonographic evaluation of the muscularis propria in cats with diffuse small intestinal lymphoma or inflammatory bowel disease. J Vet Intern Med 24, 289-292 (2010)
81. M. Garca-Sancho, F. Rodrguez-Franco, A. Sainz, C. Mancho and A. Rodrguez: Evaluation of clinical, macroscopic, and histopathologic response to treatment in nonhypoproteinemic dogs with lymphocytic-plasmacytic enteritis. J Vet Intern Med 21, 11-17 (2007)
82. B. Wilcock: Endoscopic biopsy interpretation in canine or feline enterocolitis. Semin Vet Med Surg (Small Anim) 7, 162-171 (1992)
83. M. Willard, A. Jergens, R. Duncan, M. Leib, M. McCracken, R. DeNovo, R. Helman, M. Slater and J. Harbison: Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. J Am Vet Med Assoc 220, 1177-1182 (2002)
84. G. Jacobs, L. Collins-Kelly, M. Lappin and D. Tyler: Lymphocytic- plasmacytic enteritis in 24 dogs. J Vet Intern Med 4, 45-53 (1990)
85. L. Roth, A. M. Walton, M. S. Leib and C. F. Burrows: A grading system for lymphocytic plasmacytic colitis in dogs. J Vet Diagn Invest 2, 257-262 (1990)
86. M. D. Willard, G. E. Moore, B. D. Denton, M. J. Day, J. Mansell, T. Bilzer, B. Wilcock, M. Gualtieri, D. Olivero, P. Lecoindre, D. C. Twedt, M. G. Collett, E. J. Hall, A. E. Jergens, J. W. Simpson, R. W. Else and R. J. Washabau: Effect of tissue processing on assessment of endoscopic intestinal biopsies in dogs and cats. J Vet Intern Med 24, 84-89 (2010)
87. M. J. Day, T. Bilzer, J. Mansell, B. Wilcock, E. J. Hall, A. Jergens, T. Minami, M. Willard and R. Washabau: Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the world small animal veterinary association gastrointestinal standardization group. J Comp Pathol 138, S1-S43
88. B. Wiinberg, A. Spohr, H. Dietz, T. Egelund, A. Greiter-Wilke, S. McDonough, J. Olsen, S. Priestnall, Y. Chang and K. Simpson: Quantitative analysis of inflammatory and immune responses in dogs with gastritis and their relationship to Helicobacter spp. infection. J Vet Intern Med 19, 4-14 (2005) (Pubitemid 40221698)
89. W. R. Best, J. M. Becktel, J. W. Singleton and F. Kern: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 70, 439-444 (1976)
90. M. Camilleri and M. Proano: Advances in the assessment of disease activity in inflammatory bowel disease. Mayo Clin Proc 64, 800-807 (1989) (Pubitemid 19230649)
91. R. F. Harvey and J. M. Bradshaw: A simple index of Crohn's-disease activity. Lancet 1, 514-514 (1980)
92. H. J. F. Hodgson and M. Bhatti: Assessment of disease activity in ulcerative colitis and Crohn's disease. Inflamm Bowel Dis 1, 117-134 (1995)
93. P. A. van Hees, P. H. van Elteren, H. J. van Lier and J. H. van Tongeren: An index of inflammatory activity in patients with Crohn's disease. Gut 21, 279-286 (1980) (Pubitemid 10056059)
94. A. E. Jergens, J. Crandell, J. A. Morrison, K. Deitz, M. Pressel, M. Ackermann, J. S. Suchodolski, J. M. Steiner and R. Evans: Comparison of oral prednisone and prednisone combined with metronidazole for induction therapy of canine inflammatory bowel disease: a randomized-controlled trial. J Vet Intern Med 24, 269-77 (2009)
95. M. Mnster, A. Hrauf and T. Bilzer: (Assessment of disease severity and outcome of dietary, antibiotic, and immunosuppressive interventions by use of the canine IBD activity index in 21 dogs with chronic inflammatory bowel disease). Berl Munch Tierarztl Wochenschr 119, 493-505 (2006) (Pubitemid 44807575)
96. S. Marks, D. Laflamme and D. McAloose: Dietary trial using a commercial hypoallergenic diet containing hydrolyzed protein for dogs with inflammatory bowel disease. Vet Ther 3, 109-118 (2002)
97. C. E. Ontsouka, I. A. Burgener, O. Mani and C. Albrecht: Polyunsaturated fatty acid-enriched diets used for the treatment of canine chronic enteropathies decrease the abundance of selected genes of cholesterol homeostasis. Domest Anim Endocrinol 38, 32-37 (2010)
98. K. Allenspach, P. J. Bergman, S. Sauter, A. Grne, M. G. Doherr and F. Gaschen: P-glycoprotein expression in lamina propria lymphocytes of duodenal biopsy samples in dogs with chronic idiopathic enteropathies. J Comp Pathol 134, 1-7 (2006) (Pubitemid 43103914)
99. K. Allenspach, S. Rfenacht, S. Sauter, A. Grne, J. Steffan, G. Strehlau and F. Gaschen: Pharmacokinetics and clinical efficacy of cyclosporine treatment of dogs with steroid-refractory inflammatory bowel disease. J Vet Intern Med 20, 239-244 (2006)
100. J. Tumulty, J. Broussard, J. Steiner, M. Peterson and D. Williams: Clinical effects of short-term oral budesonide on the hypothalamic-pituitary- adrenal axis in dogs with inflammatory bowel disease. J Am Anim Hosp Assoc 40, 120-123 (2004) (Pubitemid 43180274)
101. R. B. Sartor: Microbial influences in inflammatory bowel diseases. Gastroenterology 134, 577-594 (2008) (Pubitemid 351173057)
102. R. B. Sartor: Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology 126, 1620-1633 (2004) (Pubitemid 38649878)
103. H. Arndt, K. D. Palitzsch, M. B. Grisham and D. N. Granger: Metronidazole inhibits leukocyte-endothelial cell adhesion in rat mesenteric venules. Gastroenterology 106, 1271-1276 (1994) (Pubitemid 24129244)
104. G. Lichtenstein, M. Abreu, R. Cohen and W. Tremaine: American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology 130, 935-939 (2006) (Pubitemid 43374542)
105. J. B. Ewaschuk and L. A. Dieleman: Probiotics and prebiotics in chronic inflammatory bowel diseases. World J Gastroenterol 12, 5941-5950 (2006) (Pubitemid 44608471)
106. F. Guarner and J.-R. Malagelada: Gut flora in health and disease. Lancet 361 512-519 (2003) (Pubitemid 36173720)
107. A. O'Hara and F. Shanahan: Gut microbiota: mining for therapeutic potential. Clin Gastroenterol Hepatol 5, 274-284 (2007) (Pubitemid 46401524)
108. A. H. Sparkes, K. Papasouliotis, G. Sunvold, G. Werrett, E. A. Gruffydd-Jones, K. Egan, T. J. Gruffydd-Jones and G. Reinhart: Effect of dietary supplementation with fructo-oligosaccharides on fecal flora of healthy cats. Am J Vet Res 59, 436-440 (1998) (Pubitemid 128473264)
109. A. H. Sparkes, K. Papasouliotis, G. Sunvold, G. Werrett, C. Clarke, M. Jones, T. J. Gruffydd-Jones and G. Reinhart: Bacterial flora in the duodenum of healthy cats, and effect of dietary supplementation with fructooligosaccharides. Am J Vet Res 59, 431-435 (1998) (Pubitemid 128473263)
110. M. D. Willard, R. B. Simpson, N. D. Cohen and J. S. Clancy: Effects of dietary fructooligosaccharide on selected bacterial populations in feces of dogs. Am J Vet Res 61, 820-825 (2000)
111. S. N. Sauter, K. Allenspach, F. Gaschen, A. Grne, E. Ontsouka and J. W. Blum: Cytokine expression in an ex vivo culture system of duodenal samples from dogs with chronic enteropathies: modulation by probiotic bacteria. Domest Anim Endocrinol 29, 605-622 (2005) (Pubitemid 41415662)
112. S. N. Sauter, J. Benyacoub, K. Allenspach, F. Gaschen, E. Ontsouka, G. Reuteler, C. Cavadini, R. Knorr and J. W. Blum: Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet. J Anim Physiol Anim Nutr (Berl) 90, 269-277 (2006) (Pubitemid 44392309)
113. R. L. Kelley, D. Minikhiem, B. Kiely, L. O'Mahony, D. O'Sullivan, T. Boileau and J. Park: Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea. Vet Ther 10, 121-130 (2009)
114. M. Dubinsky: Serologic and laboratory markers in prediction of the disease course in inflammatory bowel disease. World J Gastroenterol 16, 2604-2608 (2010)
115. P. Lakatos and L. Kiss: Is the disease course predictable in inflammatory bowel diseases? World J Gastroenterol 16, 2591-2599 (2010)
116. F. Scaldaferri, C. Correale, A. Gasbarrini and S. Danese: Mucosal biomarkers in inflammatory bowel disease: key pathogenic players or disease predictors? World J Gastroenterol 16, 2616-2625 (2010)
117. K. Allenspach, N. Luckschander, M. Styner, F. Seibold, M. Doherr, D. Aeschbach and F. Gaschen: Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel disease. Am J Vet Res 65, 1279-1283 (2004) (Pubitemid 39232605)
118. C. Mancho, A. Sainz, M. Garca-Sancho, A. Villaescusa, M. Tesouro and F. Rodrguez-Franco: Detection of perinuclear antineutrophil cytoplasmic antibodies and antinuclear antibodies in the diagnosis of canine inflammatory bowel disease. J Vet Diagn Invest 22, 553-558 (2010)
119. K. Allenspach, B. Lomas, B. Wieland, T. Harris, B. Pressler, C. Mancho, G. Lees and S. Vaden: Evaluation of perinuclear anti-neutrophilic cytoplasmic autoantibodies as an early marker of protein-losing enteropathy and proteinlosing nephropathy in Soft Coated Wheaten Terriers. Am J Vet Res 69, 1301-1304 (2008)
120. T. M. McCann, A. E. Ridyard, R. W. Else and J. W. Simpson: Evaluation of disease activity markers in dogs with idiopathic inflammatory bowel disease. J Small Anim Pract 48, 620-625 (2007) (Pubitemid 350050355)
121. S. Vermeire, G. Van Assche and P. Rutgeerts: Laboratory markers in IBD: useful, magic, or unnecessary toys? Gut 55, 426-431 (2006) (Pubitemid 43268284)
122. M. Henriksen, J. Jahnsen, I. Lygren, N. Stray, J. Sauar, M. H. Vatn and B. Moum: C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based study. Gut 57, 1518-1523 (2008)
123. E. Kirkness, V. Bafna, A. Halpern, S. Levy, K. Remington, D. Rusch, A. Delcher, M. Pop, W. Wang, C. Fraser and J. C. Venter: The dog genome: survey sequencing and comparative analysis. Science 301 1898-1903 (2003) (Pubitemid 37221394)