Evaluation of Th1, Th2 and immunosuppressive cytokine mRNA expression within the colonic mucosa of dogs with idiopathic lymphocytic-plasmacytic colitis

Veterinary Immunology and Immunopathology

Volumn 86, Issue 3-4, 2002, Pages 205-214

  Ridyard, Alison E ^a   Nuttall, Timothy J ^b   Else, Rod W ^a   Simpson, James W ^a   Miller, Hugh R P ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Cytokines; Dog; Inflammatory bowel disease; Interleukin 2; Lymphocytic plasmacytic colitis; T helper 1; Tumour necrosis factor alpha

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; COLON; COLON MUCOSA; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIARRHEA; DOG; DOG DISEASE; HISTOPATHOLOGY; IDIOPATHIC DISEASE; LARGE INTESTINE DISEASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC COLITIS; NONHUMAN; PROTEIN EXPRESSION; RNA ISOLATION; TH1 CELL; TH2 CELL;

ANIMALS; BLOTTING, SOUTHERN; COLITIS; CYTOKINES; DNA, COMPLEMENTARY; DOG DISEASES; DOGS; FEMALE; GENE EXPRESSION REGULATION; INTESTINAL MUCOSA; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TH1 CELLS; TH2 CELLS;

CANIS FAMILIARIS;

EID: 0036240230     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(02)00039-9     Document Type: Article

References (36)

1. Functional diversity of helper T lymphocytes
2. Tumour necrosis factor alpha antibody (infliximab) therapy profoundly down regulates the inflammation in Crohn's ileocolitis
3. Lessons for human inflammatory bowel disease from experimental models
4. Inflammatory bowel disease: Etiology and pathogenesis
5. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
6. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease
7. Cytokines in experimental colitis
8. Cytokine mRNA expression in mucosal biopsies from German Shepherd dogs with small intestinal enteropathies
9. Immune cell populations within the duodenal mucosa of dogs with enteropathies
10. Mouse interleukin-12 p40 homodimer: A potent IL-12 antagonist
11. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
12. Idiopathic inflammatory bowel diseases
13. Colonic nitrite and immunoglobulin G concentrations in dogs with inflammatory bowel disease
14. Small bowel enteropathy: Role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal
15. Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumour necrosis factor-α
16. Inflammatory bowel disease: Current perspectives
17. Delayed expulsion of the nematode Trichinella spiralis in mice lack in the mucosal mast cell-specific granule chymase, mouse mast cell protease-1
18. Expression of inducible nitric oxide synthase activity in human colon epithelial cells: Modulation by T lymphocyte derived cytokines
19. Interleukin 10-deficient mice develop chronic enterocolitis
20. Quantitative assessment of mast cells and expression of IgE protein and mRNA for IgE and interleukin 4 in the gastrointestinal tract of healthy dogs and dogs with inflammatory bowel disease
21. Intra-epithelial lymphocytes: Evidence for reginal specialisation and extrathymic T cell maturation in the human gut epithelium
22. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
23. Sheep mast cell proteinases-1 and -3: CDNA cloning, primary structure and molecular modelling of the enzymes and further studies on substrate specificity
24. Cytokine regulation of epithelial permeability and ion transport
25. Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
26. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
27. Inflammatory bowel disease mucosal biopsies have specialised lymphokine mRNA profiles
28. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
29. Cytokines induce the development of functionally heterogeneous T helper cell subsets
30. Role of cytokines in the pathogenesis of inflammatory bowel disease
31. Tumour necrosis factor: Biology and therapeutic inhibitors
32. A role for TNF-α and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease
33. Colonic fluid and electrolyte transport in health and disease
34. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon-γ expression by T cells
35. Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation
36. Interleukin-2