Expression of Toll-like receptor 2 in duodenal biopsies from dogs with inflammatory bowel disease is associated with severity of disease

Veterinary Immunology and Immunopathology

Volumn 135, Issue 1-2, 2010, Pages 158-163

  McMahon, L A ^a   House, A K ^a   Catchpole, B ^a   Elson Riggins, J ^a   Riddle, A ^a   Smith, K ^a   Werling, D ^a   Burgener, I A ^b   Allenspach, K ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Dog; Inflammatory bowel disease; Toll like receptors

Indexed keywords

LIPOPOLYSACCHARIDE; LIPOPROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMMENSAL; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOG DISEASE; DUODENOSCOPY; ENTERITIS; FEMALE; GENE EXPRESSION REGULATION; GENE FUNCTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HISTOPATHOLOGY; INTESTINE BIOPSY; INTESTINE FLORA; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION;

ANIMALS; BIOPSY; DOG DISEASES; DOGS; DUODENUM; FEMALE; GENE EXPRESSION; INFLAMMATORY BOWEL DISEASES; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; TOLL-LIKE RECEPTOR 2;

BACTERIA (MICROORGANISMS); CANIS FAMILIARIS;

EID: 77951204747     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2009.11.012     Document Type: Article

References (24)

1. Abreu M.T., Fukata M., Arditi M. TLR signaling in the gut in health and disease. J. Immunol. 2005, 174:4453-4460.
2. Allenspach K., Wieland B., Grone A., Gaschen F. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J. Vet. Intern. Med. 2007, 21:700-708.
3. Burgener I.A., Konig A., Allenspach K., Sauter S.N., Boisclair J., Doherr M.G., Jungi T.W. Upregulation of Toll-like receptors in chronic enteropathies in dogs. J. Vet. Intern. Med. 2008, 22:553-560.
4. Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132:1359-1374.
5. Cario E., Podolsky D.K. Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect. Immun. 2000, 68:7010-7017.
6. Craven M., Simpson J.W., Ridyard A.E., Chandler M.L. Canine inflammatory bowel disease: retrospective analysis of diagnosis and outcome in 80 cases (1995-2002). J. Small Anim. Pract. 2004, 45:336-342.
7. Frolova L., Drastich P., Rossmann P., Klimesova K., Tlaskalova-Hogenova H. Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J. Histochem. Cytochem. 2008, 56:267-274.
8. Garcia-Sancho M., Rodriguez-Franco F., Sainz A., Mancho C., Rodriguez A. Evaluation of clinical, macroscopic, and histopathologic response to treatment in nonhypoproteinemic dogs with lymphocytic-plasmacytic enteritis. J. Vet. Intern. Med. 2007, 21:11-17.
9. German A.J., Hall E.J., Day M.J. Chronic intestinal inflammation and intestinal disease in dogs. J. Vet. Intern. Med. 2003, 17:8-20.
10. Gewirtz A.T. Intestinal epithelial Toll-like receptors: to protect and serve?. Curr. Pharm. Des. 2003, 9:1-5.
11. Gibson D.L., Ma C., Rosenberger C.M., Bergstrom K.S., Valdez Y., Huang J.T., Khan M.A., Vallance B.A. Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis. Cell Microbiol. 2008, 10:388-403.
12. Harris G., KuoLee R., Chen W. Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J. Gastroenterol. 2006, 12:2149-2160.
13. House A.K., Gregory S.P., Catchpole B. Pattern-recognition receptor mRNA expression and function in canine monocyte/macrophages and relevance to canine anal furunuclosis. Vet. Immunol. Immunopathol. 2008, 124:230-240.
14. Hurst J., von Landenberg P. Toll-like receptors and autoimmunity. Autoimmun. Rev. 2008, 7:204-208.
15. Jergens A.E. Clinical assessment of disease activity for canine inflammatory bowel disease. J. Am. Anim. Hosp. Assoc. 2004, 40:437-445.
16. Jergens A.E., Moore F.M., Haynes J.S., Miles K.G. Idiopathic inflammatory bowel disease in dogs and cats: 84 cases (1987-1990). J. Am. Vet. Med. Assoc. 1992, 201:1603-1608.
17. Pandey S., Agrawal D.K. Immunobiology of Toll-like receptors: emerging trends. Immunol. Cell Biol. 2006, 84:333-341.
18. Peters I.R., Helps C.R., Hall E.J., Day M.J. Real-time RT-PCR: considerations for efficient and sensitive assay design. J. Immunol. Methods 2004, 286:203-217.
19. Peters I.R., Peeters D., Helps C.R., Day M.J. Development and application of multiple internal reference (housekeeper) gene assays for accurate normalisation of canine gene expression studies. Vet. Immunol. Immunopathol. 2007, 117:55-66.
20. Sano J., Oguma K., Kano R., Yazawa M., Tsujimoto H., Hasegawa A. High expression of Bcl-xL in delayed apoptosis of canine neutrophils induced by lipopolysaccharide. Res. Vet. Sci. 2005, 78:183-187.
21. Shibolet O., Podolsky D.K. TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. Am. J. Physiol. 2007, 292:G1469-G1473.
22. Swerdlow M.P., Kennedy D.R., Kennedy J.S., Washabau R.J., Henthorn P.S., Moore P.F., Carding S.R., Felsburg P.J. Expression and function of TLR2, TLR4, and Nod2 in primary canine colonic epithelial cells. Vet. Immunol. Immunopathol. 2006, 114:313-319.
23. Szebeni B., Veres G., Dezsofi A., Rusai K., Vannay A., Mraz M., Majorova E., Arato A. Increased expression of Toll-like receptor (TLR) 2 and TLR4 in the colonic mucosa of children with inflammatory bowel disease. Clin. Exp. Immunol. 2008, 151:34-41.
24. Willard M.D., Jergens A.E., Duncan R.B., Leib M.S., McCracken M.D., DeNovo R.C., Helman R.G., Slater M.R., Harbison J.L. Interobserver variation among histopathologic evaluations of intestinal tissues from dogs and cats. J. Am. Vet. Med. Assoc. 2002, 220:1177-1182.