SPARC Stimulates neuronal differentiation of medulloblastoma cells via the notch1/STAT3 pathway

Cancer Research

Volumn 71, Issue 14, 2011, Pages 4908-4919

  Bhoopathi, Praveen ^a   Chetty, Chandramu ^a   Dontula, Ranadheer ^a   Gujrati, Meena ^a   Dinh, Dzung H ^a   Rao, Jasti S ^a   Lakka, Sajani S ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; COMPLEMENTARY DNA; INTERLEUKIN 6; MICROTUBULE ASSOCIATED PROTEIN 2; NESTIN; NEURON SPECIFIC NUCLEAR PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; OSTEONECTIN; SMALL INTERFERING RNA; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER GENE THERAPY; CANCER INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MEDULLOBLASTOMA; MOUSE; NERVE CELL DIFFERENTIATION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DNA, COMPLEMENTARY; GENE THERAPY; HUMANS; INTERLEUKIN-6; MEDULLOBLASTOMA; MICE; NEURONS; OSTEONECTIN; PLASMIDS; RANDOM ALLOCATION; RECEPTOR, NOTCH1; RNA, SMALL INTERFERING; STAT3 TRANSCRIPTION FACTOR; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79960405025     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-3395     Document Type: Article

References (42)

1. Crawford JR, MacDonald TJ, Packer RJ. Medulloblastoma in childhood: new biological advances. Lancet Neurol 2007;6:1073-85. (Pubitemid 350116703)
2. Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 1999;17:832-45. (Pubitemid 29109313)
3. Ehrbrecht A, Muller U, Wolter M, Hoischen A, Koch A, Radlwimmer B, et al. Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components. J Pathol 2006;208:554-63. (Pubitemid 43329342)
4. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114:97-109. (Pubitemid 47103521)
5. Artavanis-Tsakonas K, Riley EM. Innate immune response to malaria: rapid induction of IFN-gamma from human NK cells by live Plasmodium falciparum-infected erythrocytes. J Immunol 2002;169:2956-63. (Pubitemid 35013137)
6. Fan X, Matsui W, Khaki L, Stearns D, Chun J, Li YM, et al. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res 2006;66:7445-52. (Pubitemid 44289197)
7. Yan Q, Sage EH. SPARC, a matricellular glycoprotein with important biological functions. J Histochem Cytochem 1999;47:1495-506.
8. Huynh MH, Sage EH, Ringuette M. A calcium-binding motif in SPARC/osteonectin inhibits chordomesoderm cell migration during Xenopus laevis gastrulation: evidence of counter-adhesive activity in vivo. Dev Growth Differ 1999;41:407-18.
9. Chlenski A, Liu S, Guerrero LJ, Yang Q, Tian Y, Salwen HR, et al. SPARC expression is associated with impaired tumor growth, inhibited angiogenesis and changes in the extracellular matrix. Int J Cancer 2006;118:310-6. (Pubitemid 41779069)
10. Brown AL, Ringuette MJ, Prestwich GD, Bagli DJ, Woodhouse KA. Effects of hyaluronan and SPARC on fibroproliferative events assessed in an in vitro bladder acellular matrix model. Biomaterials 2006;27:3825-35.
11. Lane TF, Sage EH. The biology of SPARC, a protein that modulates cell-matrix interactions. FASEB J 1994;8:163-73.
12. Martinek N, Shahab J, Sodek J, Ringuette M. Is SPARC an evolutionarily conserved collagen chaperone?J Dent Res 2007;86:296-305.
13. Ford R, Wang G, Jannati P, Adler D, Racanelli P, Higgins PJ, et al. Modulation of SPARC expression during butyrate-induced terminal differentiation of cultured human keratinocytes: regulation via a TGF-beta-dependent pathway. Exp Cell Res 1993;206:261-75. (Pubitemid 23212944)
14. Hrabchak C, Ringuette M, Woodhouse K. Recombinant mouse SPARC promotes parietal endoderm differentiation and cardiomyogenesis in embryoid bodies. Biochem Cell Biol 2008;86:487-99.
15. Cho WJ, Kim EJ, Lee SJ, Kim HD, Shin HJ, Lim WK. Involvement of SPARC in in vitro differentiation of skeletal myoblasts. Biochem Biophys Res Commun 2000;271:630-4. (Pubitemid 30444679)
16. Martinek N, Shahab J, Saathoff M, Ringuette M. Haemocyte-derived SPARC is required for collagen-IV-dependent stability of basal laminae in Drosophila embryos. J Cell Sci 2008;121:1671-80. (Pubitemid 351911824)
17. Lawinger P, Venugopal R, Guo ZS, Immaneni A, Sengupta D, Lu W, et al. The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells. Nat Med 2000;6:826-31. (Pubitemid 30469435)
18. Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka SS. Cathepsin B facilitates autophagy mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells. Cell Death Differ 2010;17:1529-39.
19. Bigner SH, Friedman HS, Vogelstein B, Oakes WJ, Bigner DD. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 1990;50:2347-50. (Pubitemid 20134493)
20. Ali-Osman F, Stein DE, Renwick A. Glutathione content and glutathione-S-transferase expression in 1,3-bis(2-chloroethyl)-1-nitrosourea- resistant human malignant astrocytoma cell lines. Cancer Res 1990;50:6976-80. (Pubitemid 20361101)
21. Mohan PM, Barve M, Chatterjee A, Hosur RV. pH driven conformational dynamics and dimer-to-monomer transition in DLC8. Protein Sci 2006;15:335-42. (Pubitemid 43145005)
22. Bhoopathi P, Chetty C, Kunigal S, Vanamala SK, Rao JS, Lakka SS. Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB. J Biol Chem 2008;283:1545-52.
23. George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, et al. Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. J Neurosci 2009;29:3288-301.
24. Chetty C, Bhoopathi P, Lakka SS, Rao JS. MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line. Oncogene 2007;26:7675-83. (Pubitemid 350224224)
25. Nicoll RA, Malenka RC. Contrasting properties of two forms of long-term potentiation in the hippocampus. Nature 1995;377:115-8.
26. Yu LJ, Wu ML, Li H, Chen XY, Wang Q, Sun Y, et al. Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia 2008;10:736-44. (Pubitemid 351883890)
27. Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron 2008;58:52-64. (Pubitemid 351467032)
28. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol 2004;6:547-54. (Pubitemid 38786598)
29. Wang M, Wu L, Wang L, Xin X. Down-regulation of Notch1 by gamma-secretase inhibition contributes to cell growth inhibition and apoptosis in ovarian cancer cells A2780. Biochem Biophys Res Commun 2010;393:144-9.
30. Said NA, Najwer I, Socha MJ, Fulton DJ, Mok SC, Motamed K. SPARC inhibits LPA-mediated mesothelial-ovarian cancer cell crosstalk. Neoplasia 2007;9:23-35. (Pubitemid 46203932)
31. Sansone P, Storci G, Tavolari S, Guarnieri T, Giovannini C, Taffurelli M, et al. IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest 2007;117:3988-4002. (Pubitemid 350224108)
32. Matsuda T, Nakamura T, Nakao K, Arai T, Katsuki M, Heike T, et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J 1999;18:4261-9. (Pubitemid 29364128)
33. Gu F, Hata R, Ma YJ, Tanaka J, Mitsuda N, Kumon Y, et al. Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. J Neurosci Res 2005;81:163-71. (Pubitemid 41153329)
34. Yoshimatsu T, Kawaguchi D, Oishi K, Takeda K, Akira S, Masuyama N, et al. Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex. Development 2006;133:2553-63. (Pubitemid 44123404)
35. Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol 2005;23:945-74. (Pubitemid 40563190)
36. Fan X, Mikolaenko I, Elhassan I, Ni X, Wang Y, Ball D, et al. Notch1 and notch2 have opposite effects on embryonal brain tumor growth. Cancer Res 2004;64:7787-93. (Pubitemid 39446911)
37. Kallen KJ. The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases. Biochim Biophys Acta 2002;1592:323-43.
38. Hodge DR, Hurt EM, Farrar WL. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 2005;41:2502-12. (Pubitemid 41540626)
39. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, et al. Regulation of gliogenesis in the central nervous system by the JAKSTAT signaling pathway. Science 1997;278:477-83. (Pubitemid 27454434)
40. Ferrari AC, Waxman S. Differentiation agents in cancer therapy. Cancer Chemother Biol Response Modif 1994;15:337-66.
41. Romer J, Curran T. Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res 2005;65:4975-8. (Pubitemid 40827300)
42. Tai IT, Dai M, Owen DA, Chen LB. Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest 2005;115:1492-502. (Pubitemid 40814658)