Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15371-15379

  Cao, Qin ^a   Wang, Xiao Jun ^a   Liu, Cheng Wen ^b   Liu, Dai Fei ^a   Li, Lan Fen ^a   Gao, Yi Qin ^b   Su, Xiao Dong ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; APOPTOTIC; BIOCHEMICAL ASSAY; DRUG DESIGN; DRUG TARGETS; HUNTINGTON DISEASE; INHIBITION MECHANISMS; INHIBITORY MECHANISM; MOLECULAR DYNAMICS SIMULATIONS; NEURODEGENERATION; SELF-ACTIVATION; SOLVED CRYSTAL STRUCTURES; STERIC HINDRANCES; STRUCTURAL INVESTIGATION;

ASSAYS; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; NEURODEGENERATIVE DISEASES;

PHOSPHORYLATION;

ALANINE; CASPASE 6; ENZYME PRECURSOR; GLUTAMIC ACID; GLYCINE; LYSINE; PROLINE; SERINE; THROMBIN; TYROSINE;

ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIMULATION; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; CASPASE 6; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SERINE;

EID: 84860853336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.351213     Document Type: Article

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