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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5244-5247

Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation

(6) Müller, Ilka a Lamers, Marieke B A C a Ritchie, Alison J a Dominguez, Celia b Munoz Sanjuan, Ignacio b Kiselyov, Alex b

a BioFocus DPI (United Kingdom)

b CHDI MANAGEMENT CHDI FOUNDATION (United States)

Author keywords

Apoptosis; Human caspase 6; Huntington's Disease; Irreversible inhibitor binding; Structure based drug design

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 6;

ARTICLE; COMPLEX FORMATION; CRYSTALLIZATION; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; ENZYME CONFORMATION; ENZYME PURIFICATION; ENZYME STRUCTURE; MOLECULAR INTERACTION; PH; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

AMINO ACID CHLOROMETHYL KETONES; BINDING SITES; CASPASE 6; CYSTEINE PROTEINASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051935810 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.041 Document Type: Article

Times cited : (15)

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