A novel heparin-dependent inhibitor of activated protein C that potentiates consumptive coagulopathy in Russell's viper envenomation

Journal of Biological Chemistry

Volumn 287, Issue 19, 2012, Pages 15739-15748

  Cheng, An Chun ^a   Wu, Hua Lin ^b,c   Shi, Guey Yueh ^b,c   Tsai, Inn Ho ^a,d  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT ACTIVITIES; ASSOCIATION RATE CONSTANTS; BINDING ASSAYS; BINDING KINETICS; BLOOD COAGULATION; CHROMOGENIC SUBSTRATE; COAGULATION FACTOR; FIBRINOGEN CONCENTRATION; GLOMERULAR CAPILLARIES; KINETIC STUDY; POTENTIALLY FATAL; SERINE PROTEASE; THROMBIN GENERATION; TIGHT BINDING;

ACTIVATION ANALYSIS; AMINO ACIDS; BINDING ENERGY; BINDING SITES; CHEMICAL ACTIVATION; COAGULATION; GLYCOPROTEINS; PLASMA DEPOSITION; RATE CONSTANTS;

POLYSACCHARIDES;

ACTIVATED PROTEIN C; ACTIVATED PROTEIN C INHIBITOR; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 5; DABOIA RUSSELII KUNITZ INHIBITOR I; FIBRIN; FIBRINOGEN; HEPARIN; PROTEIN INHIBITOR; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DABOIA RUSSELLII; DISSEMINATED INTRAVASCULAR CLOTTING; DOWN REGULATION; DRUG PROTEIN BINDING; ENVENOMATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; GENE EXPRESSION; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; RAT; SURFACE PLASMON RESONANCE; THROMBOSIS;

AMINO ACID SEQUENCE; ANIMALS; BLOOD COAGULATION; CARRIER PROTEINS; CLONING, MOLECULAR; DISSEMINATED INTRAVASCULAR COAGULATION; DNA, COMPLEMENTARY; DRUG SYNERGISM; HEPARIN; HUMANS; KINETICS; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN C; PROTEIN C INHIBITOR; RUSSELL'S VIPER; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; VIPER VENOMS;

MUS; VIPERINAE;

EID: 84860852655     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.323063     Document Type: Article

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