Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2

American Journal of Physiology - Renal Physiology

Volumn 293, Issue 1, 2007, Pages

  Gupta, Akanksha ^a   Rhodes, George J ^b   Berg, David T ^a   Gerlitz, Bruce ^a   Molitoris, Bruce A ^b   Grinnell, Brian W ^a  

^a ELI LILLY AND COMPANY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endotoxin; Two photon intravital microscopy

Indexed keywords

ACTIVATED PROTEIN C; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROTEIN C; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY FLOW; CONTROLLED STUDY; DOWN REGULATION; ENDOTOXEMIA; KIDNEY BLOOD FLOW; KIDNEY TUBULE; MALE; MICROSCOPY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RENAL PROTECTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STATISTICAL SIGNIFICANCE; UREA NITROGEN BLOOD LEVEL; VASOCONSTRICTION; ANIMAL; BIOSYNTHESIS; BLOOD; CELL ADHESION; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; KIDNEY; KIDNEY CIRCULATION; LEUKOCYTE; MACROPHAGE ACTIVATION; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; VASODILATATION;

ANGIOTENSIN II; ANIMALS; BLOOD UREA NITROGEN; CELL ADHESION; DOWN-REGULATION; ENDOTOXEMIA; KIDNEY; KIDNEY FAILURE, ACUTE; LEUKOCYTES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN C; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; RENIN-ANGIOTENSIN SYSTEM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UREA; VASOCONSTRICTION; VASODILATION;

EID: 34548051791     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00477.2006     Document Type: Article

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