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Volumn 1, Issue 7, 2003, Pages 1504-1514

What is all that thrombin for?

Author keywords

Fibrin; Hemostasis; Thrombin; Thrombosis; Tissue factor

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 9A; THROMBIN;

EID: 0141498160     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1046/j.1538-7836.2003.00298.x     Document Type: Review
Times cited : (487)

References (70)
  • 1
    • 0037813859 scopus 로고    scopus 로고
    • Rochester MN: Mayo Foundation for Medical Education and Research
    • Owen CAA, Jr. History of Blood Coagulation. Rochester MN: Mayo Foundation for Medical Education and Research, 2001.
    • (2001) History of Blood Coagulation
    • Owen Jr., C.A.A.1
  • 4
    • 0001518432 scopus 로고
    • Die chemie der blutgerrinnung
    • Morawitz P. Die chemie der blutgerrinnung. Ergebn Physiol 1905; 4: 307.
    • (1905) Ergebn Physiol , vol.4 , pp. 307
    • Morawitz, P.1
  • 5
    • 0002008477 scopus 로고
    • The prothrombin time in haemophilia and in obstructive jaudice
    • Quick AJ. The prothrombin time in haemophilia and in obstructive jaudice. J Biol Chem 1935; 109: 73-4.
    • (1935) J Biol Chem , vol.109 , pp. 73-74
    • Quick, A.J.1
  • 6
    • 50449147939 scopus 로고
    • Effect of antihemophilic factor on one-stage clotting tests: a presumptive test of hemophilia and a single one-stage anti-hemophilic factor assay procedure
    • Langdell RD, Wagner RH, Brinkhous KM, W. Effect of antihemophilic factor on one-stage clotting tests: a presumptive test of hemophilia and a single one-stage anti-hemophilic factor assay procedure. J Lab Clin Med 1953; 41: 7637-47.
    • (1953) J Lab Clin Med , vol.41 , pp. 7637-7647
    • Langdell, R.D.1    Wagner, R.H.2    Brinkhous, K.M.W.3
  • 7
    • 37049044629 scopus 로고    scopus 로고
    • An enzyme cascade in the blood clotting mechanism and its function as a biochemical amplifier
    • MacFarlane RG. An enzyme cascade in the blood clotting mechanism and its function as a biochemical amplifier. Nature 2000; 202: 498-9.
    • (2000) Nature , vol.202 , pp. 498-499
    • MacFarlane, R.G.1
  • 8
    • 37049242417 scopus 로고
    • Waterfall sequence for intrinstic blood clotting
    • Davie EW, Ratnoff OD. Waterfall sequence for intrinstic blood clotting. Science 1964; 145: 1310-2.
    • (1964) Science , vol.145 , pp. 1310-1312
    • Davie, E.W.1    Ratnoff, O.D.2
  • 9
    • 0017639138 scopus 로고
    • Activation of factor IX by the reaction product of tissue factor and factor VII. additional pathway for initiating blood coagulation
    • Osterud B, Rapaport SI. Activation of factor IX by the reaction product of tissue factor and factor VII. additional pathway for initiating blood coagulation. Proc Natl Acad Sci USA 1977; 74: 5260-4.
    • (1977) Proc Natl Acad Sci USA , vol.74 , pp. 5260-5264
    • Osterud, B.1    Rapaport, S.I.2
  • 10
    • 0025874052 scopus 로고
    • Factor XI activation in a revised model of blood coagulation
    • Gailani D, Broze GJ, Jr. Factor XI activation in a revised model of blood coagulation. Science 1991; 253 (5022): 909-12.
    • (1991) Science , vol.253 , Issue.5022 , pp. 909-912
    • Gailani, D.1    Broze Jr., G.J.2
  • 11
    • 0025772165 scopus 로고
    • Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation
    • Lawson JH, Mann KG. Cooperative activation of human factor IX by the human extrinsic pathway of blood coagulation. J Biol Chem 1991; 266: 11317-27.
    • (1991) J Biol Chem , vol.266 , pp. 11317-11327
    • Lawson, J.H.1    Mann, K.G.2
  • 13
    • 0033693676 scopus 로고    scopus 로고
    • Phenotyping the clotting system
    • Hemker HC, Beguin S. Phenotyping the clotting system. Thromb Haemost 2000; 84: 747-51.
    • (2000) Thromb Haemost , vol.84 , pp. 747-751
    • Hemker, H.C.1    Beguin, S.2
  • 14
    • 0029794555 scopus 로고    scopus 로고
    • Targeted disruption of the murine tissue factor gene results in embryonic lethality
    • Toomey JR, Kratzer KE, Lasky NM, Stanton JJ, Broze GJ Jr Targeted disruption of the murine tissue factor gene results in embryonic lethality. Blood 1996; 88: 1583-7.
    • (1996) Blood , vol.88 , pp. 1583-1587
    • Toomey, J.R.1    Kratzer, K.E.2    Lasky, N.M.3    Stanton, J.J.4    Broze Jr., G.J.5
  • 16
    • 0030738021 scopus 로고    scopus 로고
    • Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice
    • Huang ZF, Higuchi D, Lasky N, Broze GJ Jr Tissue factor pathway inhibitor gene disruption produces intrauterine lethality in mice. Blood 1997; 90: 944-51.
    • (1997) Blood , vol.90 , pp. 944-951
    • Huang, Z.F.1    Higuchi, D.2    Lasky, N.3    Broze Jr., G.J.4
  • 17
  • 18
    • 0029854371 scopus 로고    scopus 로고
    • Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V
    • Cui J, O'Shea KS, Purkayastha A, Saunders TL, Ginsburg D. Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Nature 1996; 384 (6604): 66-8.
    • (1996) Nature , vol.384 , Issue.6604 , pp. 66-68
    • Cui, J.1    O'Shea, K.S.2    Purkayastha, A.3    Saunders, T.L.4    Ginsburg, D.5
  • 20
    • 0032532678 scopus 로고    scopus 로고
    • Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice
    • Jalbert LR, Rosen ED, Moons L, Chan JC, Carmeliet P, Collen D, Castellino FJ. Inactivation of the gene for anticoagulant protein C causes lethal perinatal consumptive coagulopathy in mice. J Clin Invest 1998; 102: 1481-8.
    • (1998) J Clin Invest , vol.102 , pp. 1481-1488
    • Jalbert, L.R.1    Rosen, E.D.2    Moons, L.3    Chan, J.C.4    Carmeliet, P.5    Collen, D.6    Castellino, F.J.7
  • 24
    • 0023598212 scopus 로고
    • Progress in standardization in anticoagulant control
    • Poller L. Progress in standardization in anticoagulant control. Hematol Rev 1987; 1: 225-41.
    • (1987) Hematol Rev , vol.1 , pp. 225-241
    • Poller, L.1
  • 26
    • 0035200095 scopus 로고    scopus 로고
    • The role of platelets in decrypting monocyte tissue factor
    • Osterud B. The role of platelets in decrypting monocyte tissue factor. Semin Hematol 2001; 38 (4 Suppl. 12): 2-5.
    • (2001) Semin Hematol , vol.38 , Issue.4 SUPPL. 12 , pp. 2-5
    • Osterud, B.1
  • 29
    • 0028106188 scopus 로고
    • Tissue factor in plasma of patients with disseminated intravascular coagulation
    • Takahashi H, Satoh N, Wada K, Takakuwa E, Seki Y, Shibata A. Tissue factor in plasma of patients with disseminated intravascular coagulation. Am J Hematol 1994; 46: 333-7.
    • (1994) Am J Hematol , vol.46 , pp. 333-337
    • Takahashi, H.1    Satoh, N.2    Wada, K.3    Takakuwa, E.4    Seki, Y.5    Shibata, A.6
  • 30
    • 0027402655 scopus 로고
    • Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation
    • Morrissey JH, Macik BG, Neuenschwander PF, Comp PC. Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993; 81: 734-44.
    • (1993) Blood , vol.81 , pp. 734-744
    • Morrissey, J.H.1    Macik, B.G.2    Neuenschwander, P.F.3    Comp, P.C.4
  • 31
    • 0034651933 scopus 로고    scopus 로고
    • Inhibition of thrombin generation by the zymogen factor VII. implications for the treatment of hemophilia A by factor VIIa
    • van 't Veer C, Golden NJ, Mann KG. Inhibition of thrombin generation by the zymogen factor VII. implications for the treatment of hemophilia A by factor VIIa. Blood 2000; 95: 1330-5.
    • (2000) Blood , vol.95 , pp. 1330-1335
    • van 't Veer, C.1    Golden, N.J.2    Mann, K.G.3
  • 32
    • 0018627168 scopus 로고
    • Kinetics of the tissue factor-dependent activation of coagulation Factors IX and X in a bovine plasma system
    • Jesty J, Silverberg SA. Kinetics of the tissue factor-dependent activation of coagulation Factors IX and X in a bovine plasma system. J Biol Chem 1979; 254: 12337-45.
    • (1979) J Biol Chem , vol.254 , pp. 12337-12345
    • Jesty, J.1    Silverberg, S.A.2
  • 34
    • 0021242251 scopus 로고
    • Tissue factor-dependent activation of tritiumlabeled factor IX and factor X in human plasma
    • Morrison SA, Jesty J. Tissue factor-dependent activation of tritiumlabeled factor IX and factor X in human plasma. Blood 1984; 63: 1338-47.
    • (1984) Blood , vol.63 , pp. 1338-1347
    • Morrison, S.A.1    Jesty, J.2
  • 35
    • 0026577704 scopus 로고
    • Characterization of a functional thrombin receptor. Issues and opportunities
    • Coughlin SR, Vu TK, Hung DT, Wheaton VI. Characterization of a functional thrombin receptor. Issues and opportunities. J Clin Invest 1992; 89: 351-5.
    • (1992) J Clin Invest , vol.89 , pp. 351-355
    • Coughlin, S.R.1    Vu, T.K.2    Hung, D.T.3    Wheaton, V.I.4
  • 36
    • 0028064839 scopus 로고
    • A model for the tissue factor pathway to thrombin. I. An empirical study
    • Lawson JH, Kalafatis M, Stram S, Mann KG. A model for the tissue factor pathway to thrombin. I. An empirical study. J Biol Chem 1994; 269: 23357-66.
    • (1994) J Biol Chem , vol.269 , pp. 23357-23366
    • Lawson, J.H.1    Kalafatis, M.2    Stram, S.3    Mann, K.G.4
  • 37
    • 0023821390 scopus 로고
    • The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets
    • Nesheim ME, Pittman DD, Wang JH, Slonosky D, Giles AR, Kaufman RJ. The binding of 35S-labeled recombinant factor VIII to activated and unactivated human platelets. J Biol Chem 1988; 263: 16467-70.
    • (1988) J Biol Chem , vol.263 , pp. 16467-16470
    • Nesheim, M.E.1    Pittman, D.D.2    Wang, J.H.3    Slonosky, D.4    Giles, A.R.5    Kaufman, R.J.6
  • 38
    • 0023924910 scopus 로고
    • Cofactor proteins in the assembly and expression of blood clotting enzyme complexes
    • Mann KG, Jenny RJ, Krishnaswamy S. Cofactor proteins in the assembly and expression of blood clotting enzyme complexes. Annu Rev Biochem 1988; 57: 915-56.
    • (1988) Annu Rev Biochem , vol.57 , pp. 915-956
    • Mann, K.G.1    Jenny, R.J.2    Krishnaswamy, S.3
  • 39
    • 0021046120 scopus 로고
    • The factor Xa-catalyzed activation of factor V
    • Foster WB, NesheimME, Mann KG. The factor Xa-catalyzed activation of factor V. J Biol Chem 1983; 258: 13970-7.
    • (1983) J Biol Chem , vol.258 , pp. 13970-13977
    • Foster, W.B.1    Nesheim, M.E.2    Mann, K.G.3
  • 40
    • 0025788582 scopus 로고
    • Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces
    • Naito K, Fujikawa K. Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces. J Biol Chem 1991; 266: 7353-8.
    • (1991) J Biol Chem , vol.266 , pp. 7353-7358
    • Naito, K.1    Fujikawa, K.2
  • 41
    • 13244278956 scopus 로고
    • Tissue-factor inhibitor is also a factor Xa inhibitor
    • Broze GJ Jr Tissue-factor inhibitor is also a factor Xa inhibitor. Clin Res 1987; 35: 597.
    • (1987) Clin Res , vol.35 , pp. 597
    • Broze Jr., G.J.1
  • 42
    • 0032549024 scopus 로고    scopus 로고
    • Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor
    • Baugh RJ, Broze GJ Jr, Krishnaswamy S. Regulation of extrinsic pathway factor Xa formation by tissue factor pathway inhibitor. J Biol Chem 1998; 273: 4378-86.
    • (1998) J Biol Chem , vol.273 , pp. 4378-4386
    • Baugh, R.J.1    Broze Jr., G.J.2    Krishnaswamy, S.3
  • 43
    • 0027498670 scopus 로고
    • Kinetic characterization of heparincatalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin
    • Olson ST, Bjork I, Shore JD. Kinetic characterization of heparincatalyzed and uncatalyzed inhibition of blood coagulation proteinases by antithrombin. Meth Enzymol 1993; 222: 525-59.
    • (1993) Meth Enzymol , vol.222 , pp. 525-559
    • Olson, S.T.1    Bjork, I.2    Shore, J.D.3
  • 44
    • 0026806898 scopus 로고
    • Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa
    • Shigematsu Y, Miyata T, Higashi S, Miki T, Sadler JE, Iwanaga S. Expression of human soluble tissue factor in yeast and enzymatic properties of its complex with factor VIIa. J Biol Chem 1992; 267: 21329-37.
    • (1992) J Biol Chem , vol.267 , pp. 21329-21337
    • Shigematsu, Y.1    Miyata, T.2    Higashi, S.3    Miki, T.4    Sadler, J.E.5    Iwanaga, S.6
  • 45
    • 0027475222 scopus 로고
    • Complex-dependent inhibition of factor VIIa by antithrombin III and heparin
    • Lawson JH, Butenas S, Ribarik N, Mann KG. Complex-dependent inhibition of factor VIIa by antithrombin III and heparin. J Biol Chem 1993; 268: 767-70.
    • (1993) J Biol Chem , vol.268 , pp. 767-770
    • Lawson, J.H.1    Butenas, S.2    Ribarik, N.3    Mann, K.G.4
  • 46
    • 0026057777 scopus 로고
    • Leukocyte chemoattractant peptides from the serpin heparin cofactor II
    • Church FC, Pratt CW, Hoffman M. Leukocyte chemoattractant peptides from the serpin heparin cofactor II. J Biol Chem 1991; 266: 704-9.
    • (1991) J Biol Chem , vol.266 , pp. 704-709
    • Church, F.C.1    Pratt, C.W.2    Hoffman, M.3
  • 47
    • 0020321012 scopus 로고
    • Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma
    • Tollefsen DM, Majerus DW, Blank MK. Heparin cofactor II. Purification and properties of a heparin-dependent inhibitor of thrombin in human plasma. J Biol Chem 1982; 257: 2162-9.
    • (1982) J Biol Chem , vol.257 , pp. 2162-2169
    • Tollefsen, D.M.1    Majerus, D.W.2    Blank, M.K.3
  • 48
    • 0024558370 scopus 로고
    • The roles of protein C and thrombomodulin in the regulation of blood coagulation
    • Esmon CT. The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989; 264: 4743-6.
    • (1989) J Biol Chem , vol.264 , pp. 4743-4746
    • Esmon, C.T.1
  • 49
    • 0025888388 scopus 로고
    • Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity
    • Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem 1991; 266: 20139-45.
    • (1991) J Biol Chem , vol.266 , pp. 20139-20145
    • Fay, P.J.1    Smudzin, T.M.2    Walker, F.J.3
  • 50
    • 0028110027 scopus 로고
    • The mechanism of inactivation of human factor Vand human factor Va by activated protein C
    • Kalafatis M, Rand MD, Mann KG. The mechanism of inactivation of human factor Vand human factor Va by activated protein C. J Biol Chem 1994; 269: 31869-80.
    • (1994) J Biol Chem , vol.269 , pp. 31869-31880
    • Kalafatis, M.1    Rand, M.D.2    Mann, K.G.3
  • 51
    • 0037166290 scopus 로고    scopus 로고
    • A model for the stoichiometric regulation of blood coagulation
    • Hockin MF, Jones KC, Everse SJ, Mann KG. A model for the stoichiometric regulation of blood coagulation. J Biol Chem 2002; 277: 18322-33.
    • (2002) J Biol Chem , vol.277 , pp. 18322-18333
    • Hockin, M.F.1    Jones, K.C.2    Everse, S.J.3    Mann, K.G.4
  • 52
    • 0033214353 scopus 로고    scopus 로고
    • 'Normal' thrombin generation
    • Butenas S, van't Veer C, Mann KG. 'Normal' thrombin generation. Blood 1999; 94: 2169-78.
    • (1999) Blood , vol.94 , pp. 2169-2178
    • Butenas, S.1    van't Veer, C.2    Mann, K.G.3
  • 53
    • 0031058039 scopus 로고    scopus 로고
    • Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin- III, and heparin cofactor-II
    • van 't Veer C, Mann KG. Regulation of tissue factor initiated thrombin generation by the stoichiometric inhibitors tissue factor pathway inhibitor, antithrombin- III, and heparin cofactor-II. J Biol Chem 1997; 272: 4367-77.
    • (1997) J Biol Chem , vol.272 , pp. 4367-4377
    • van 't Veer, C.1    Mann, K.G.2
  • 54
    • 0027936105 scopus 로고
    • A model for the tissue factor pathway to thrombin. II. A mathematical simulation
    • [published erratum appears in J Biol Chem 1995; 270: 9026]
    • Jones KC, Mann KG. A model for the tissue factor pathway to thrombin. II. A mathematical simulation. J Biol Chem 1994; 269: 23367-73[published erratum appears in J Biol Chem 1995; 270: 9026].
    • (1994) J Biol Chem , vol.269 , pp. 23367-23373
    • Jones, K.C.1    Mann, K.G.2
  • 55
    • 0033602920 scopus 로고    scopus 로고
    • A model describing the inactivation of factor Va by APC. Bond cleavage, fragment dissociation, and product inhibition
    • Hockin MF, Cawthern KM, Kalafatis M, Mann KG. A model describing the inactivation of factor Va by APC. Bond cleavage, fragment dissociation, and product inhibition. Biochemistry 1999; 38: 6918-34.
    • (1999) Biochemistry , vol.38 , pp. 6918-6934
    • Hockin, M.F.1    Cawthern, K.M.2    Kalafatis, M.3    Mann, K.G.4
  • 57
    • 0036660207 scopus 로고    scopus 로고
    • Thrombin functions during tissue factor-induced blood coagulation
    • Brummel KE, Paradis SG, Butenas S, Mann KG. Thrombin functions during tissue factor-induced blood coagulation. Blood 2002; 100: 148-52.
    • (2002) Blood , vol.100 , pp. 148-152
    • Brummel, K.E.1    Paradis, S.G.2    Butenas, S.3    Mann, K.G.4
  • 58
    • 0035826856 scopus 로고    scopus 로고
    • Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, factor XIII and by enhancing factor Va inactivation
    • Undas A, Brummel KE, Musial J, Mann KG, Szczeklik A. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, factor XIII and by enhancing factor Va inactivation. Circulation 2001; 103: 2248-53.
    • (2001) Circulation , vol.103 , pp. 2248-2253
    • Undas, A.1    Brummel, K.E.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 59
    • 33645299426 scopus 로고    scopus 로고
    • Aspirin and cardioprotective effects of the Val34Leu polymorphism of factor XIII
    • [Abstract]
    • Undas A, Brummel KE, Musial J, Mann KG, Szczeklik A. Aspirin and cardioprotective effects of the Val34Leu polymorphism of factor XIII. Circulation; 104: II-12[Abstract].
    • Circulation , vol.104
    • Undas, A.1    Brummel, K.E.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 60
    • 0037422559 scopus 로고    scopus 로고
    • Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism
    • Undas A, Wojciech JS, Brummel K, Musial J, Mann K, Szczeklik A. Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism. Circulation 2003; 173: 17-20.
    • (2003) Circulation , vol.173 , pp. 17-20
    • Undas, A.1    Wojciech, J.S.2    Brummel, K.3    Musial, J.4    Mann, K.5    Szczeklik, A.6
  • 62
    • 0033529539 scopus 로고    scopus 로고
    • An integrated study of fibrinogen during blood coagulation
    • Brummel KE, Butenas S, Mann KG. An integrated study of fibrinogen during blood coagulation. J Biol Chem 1999; 274: 22862-70.
    • (1999) J Biol Chem , vol.274 , pp. 22862-22870
    • Brummel, K.E.1    Butenas, S.2    Mann, K.G.3
  • 63
    • 0345195222 scopus 로고    scopus 로고
    • Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor
    • van't Veer C, Golden NJ, Kalafatis M, Mann KG. Inhibitory mechanism of the protein C pathway on tissue factor-induced thrombin generation. Synergistic effect in combination with tissue factor pathway inhibitor. J Biol Chem 1997; 272: 7983-94.
    • (1997) J Biol Chem , vol.272 , pp. 7983-7994
    • van't Veer, C.1    Golden, N.J.2    Kalafatis, M.3    Mann, K.G.4
  • 64
    • 0037220079 scopus 로고    scopus 로고
    • Factor V: a combination of Dr. Jekyll and Mr. Hyde
    • Mann KG, Kalafatis M. Factor V: a combination of Dr. Jekyll and Mr. Hyde. Blood 2003; 101: 20-30.
    • (2003) Blood , vol.101 , pp. 20-30
    • Mann, K.G.1    Kalafatis, M.2
  • 65
    • 0002800925 scopus 로고    scopus 로고
    • Factor XI
    • Cloman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Philadelphia: Lippincott Williams & Wilkins
    • Walsh PN. Factor XI. In: Cloman RW, Hirsh J, Marder VJ, Clowes AW, George JN, eds. Hemostasis and Thrombosis: Basic Principles & Clinical Practice. Philadelphia: Lippincott Williams & Wilkins, 2001.
    • (2001) Hemostasis and Thrombosis: Basic Principles & Clinical Practice
    • Walsh, P.N.1
  • 66
    • 0035889148 scopus 로고    scopus 로고
    • Blood coagulation at the site of microvascular injury: effects of low-dose aspirin
    • Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Blood coagulation at the site of microvascular injury: effects of low-dose aspirin. Blood 2001; 98: 2423-31.
    • (2001) Blood , vol.98 , pp. 2423-2431
    • Undas, A.1    Brummel, K.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 69
    • 1642530216 scopus 로고    scopus 로고
    • Increased tissue factor-initiated prothrombin activation as a result of the Arg506!Gln mutation in factor V LEIDEN
    • van't Veer C, Kalafatis M, Bertina RM, Simioni P, Mann KG. Increased tissue factor-initiated prothrombin activation as a result of the Arg506!Gln mutation in factor V LEIDEN. J Biol Chem 1997; 272: 20721-9.
    • (1997) J Biol Chem , vol.272 , pp. 20721-20729
    • van't Veer, C.1    Kalafatis, M.2    Bertina, R.M.3    Simioni, P.4    Mann, K.G.5
  • 70
    • 0037035484 scopus 로고    scopus 로고
    • Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden
    • Eitzman DT, Westrick RJ, Bi X, Manning SL, Wilkinson JE, Broze GJ, Ginsburg D. Lethal perinatal thrombosis in mice resulting from the interaction of tissue factor pathway inhibitor deficiency and factor V Leiden. Circulation 2002; 105: 2139-42.
    • (2002) Circulation , vol.105 , pp. 2139-2142
    • Eitzman, D.T.1    Westrick, R.J.2    Bi, X.3    Manning, S.L.4    Wilkinson, J.E.5    Broze, G.J.6    Ginsburg, D.7


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