Gadolinium modulates gentamicin uptake via an endocytosis-independent pathway in HK-2 human renal proximal tubular cell line

European Journal of Pharmacology

Volumn 684, Issue 1-3, 2012, Pages 146-153

  Sawada, Takeshi ^a   Nagai, Junya ^a   Okada, Yumi ^a   Yumoto, Ryoko ^a   Takano, Mikihisa ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Cellular uptake; Endocytosis independent pathway; Gadolinium; Gentamicin; HK 2 cell; Renal proximal tubular cell

Indexed keywords

ALANINE; AMIKACIN; AMINOGLYCOSIDE; CALCIUM; COLCHICINE; CYTOCHALASIN D; GADOLINIUM; GENTAMICIN; GLUCOSE; HABEKACIN; KANAMYCIN; MEGALIN; MESSENGER RNA; N WASP 181 200; NEOMYCIN; PEPTIDE; RUTHENIUM RED; SODIUM; STREPTOMYCIN; TOBRAMYCIN; TRITIUM; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL FUNCTION; CELL LINE; CELL STRAIN HK 2; CELL STRAIN OK; CONTROLLED STUDY; DRUG UPTAKE; ENDOCYTOSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; INTERNALIZATION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALANINE; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; CALCIUM; CELL LINE; ENDOCYTOSIS; EXTRACELLULAR SPACE; GADOLINIUM; GENE EXPRESSION REGULATION; GENTAMICINS; GLUCOSE; HUMANS; INTRACELLULAR SPACE; ION CHANNELS; KIDNEY TUBULES, PROXIMAL; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-2; RNA, MESSENGER; RUTHENIUM RED; SODIUM; TEMPERATURE;

EID: 84860838717     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.030     Document Type: Article

References (43)

1. C.J. Bailey Renal glucose reabsorption inhibitors to treat diabetes Trends Pharmacol. Sci. 32 2011 63 71
2. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
3. E.I. Christensen, and H. Birn Megalin and cubilin: multifunctional endocytic receptors Nat. Rev. Mol. Cell Biol. 3 2002 256 266 (Pubitemid 34619261)
4. E.I. Christensen, S. Nielsen, S.K. Moestrup, C. Borre, A.B. Maunsbach, E. de Heer, P. Ronco, T.G. Hammond, and P. Verroust Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules Eur. J. Cell Biol. 66 1995 349 364
5. E.I. Christensen, O. Devuyst, G. Dom, R. Nielsen, P. Van der Smissen, P. Verroust, M. Leruth, W.B. Guggino, and P.J. Courtoy Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules Proc. Natl. Acad. Sci. U.S.A. 100 2003 8472 8477 (Pubitemid 36842569)
6. E.I. Christensen, P.J. Verroust, and R. Nielsen Receptor-mediated endocytosis in renal proximal tubule Pflugers Arch. 458 2009 1039 1048
7. J.J. Gildea, I. Shah, R. Weiss, N.D. Casscells, H.E. McGrath, J. Zhang, J.E. Jones, and R.A. Felder HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling Hypertension 56 2010 505 511
8. K.A. Holthouser, A. Mandal, M.L. Merchant, J.R. Schelling, N.A. Delamere, R.R. Valdes Jr., S.C. Tyagi, E.D. Lederer, and S.J. Khundmiri Ouabain stimulates Na-K-ATPase through a sodium/hydrogen exchanger-1 (NHE-1)-dependent mechanism in human kidney proximal tubule cells Am. J. Physiol. Renal Physiol. 299 2010 F77 F90
9. 1) J. Pharmacol. Exp. Ther. 261 1992 1200 1205
10. M. Iwata, and R.A. Zager Myoglobin inhibits proliferation of cultured human proximal tubular (HK-2) cells Kidney Int. 50 1996 796 804 (Pubitemid 26302667)
11. T. Karasawa, Q. Wang, Y. Fu, D.M. Cohen, and P.S. Steyger TRPV4 enhances the cellular uptake of aminoglycoside antibiotics J. Cell Sci. 121 2008 2871 2879
12. M. Li, S. Balamuthusamy, E.E. Simon, and V. Batuman Silencing megalin and cubilin genes inhibits myeloma light chain endocytosis and ameliorates toxicity in human renal proximal tubule epithelial cells Am. J. Physiol. Renal Physiol. 295 2008 F82 F90
13. J.M. Lopez-Novoa, Y. Quiros, L. Vicente, A.I. Morales, and F.J. Lopez-Hernandez New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view Kidney Int. 79 2011 33 45
14. M.P. Mingeot-Leclercq, and P.M. Tulkens Aminoglycosides: nephrotoxicity Antimicrob. Agents Chemother. 43 1999 1003 1012 (Pubitemid 29214718)
15. S.K. Moestrup, S. Cui, H. Vorum, C. Bregengård, S.E. Bjorn, K. Norris, J. Gliemann, and E.I. Christensen Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs J. Clin. Invest. 96 1995 1404 1413
16. B.A. Molitoris, C. Meyer, R. Dahl, and A. Geerdes Mechanism of ischemia-enhanced aminoglycoside binding and uptake by proximal tubule cells Am. J. Physiol. 264 1993 F907 F916
17. S.E. Myrdal, and P.S. Steyger TRPV1 regulators mediate gentamicin penetration of cultured kidney cells Hear. Res. 204 2005 170 182 (Pubitemid 40733214)
18. S.E. Myrdal, K.C. Johnson, and P.S. Steyger Cytoplasmic and intra-nuclear binding of gentamicin does not require endocytosis Hear. Res. 204 2005 156 169 (Pubitemid 40733213)
19. J. Nagai, and M. Takano Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity Drug Metab. Pharmacokinet. 19 2004 159 170
20. J. Nagai, H. Tanaka, N. Nakanishi, T. Murakami, and M. Takano Role of megalin in renal handling of aminoglycosides Am. J. Physiol. Renal Physiol. 281 2001 F337 F344
21. J. Nagai, M. Saito, Y. Adachi, R. Yumoto, and M. Takano Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides J. Control. Release 112 2006 43 50
22. 1, expressing endocytotic active megalin J. Am. Soc. Nephrol. 9 1998 1767 1776 (Pubitemid 28443473)
23. R.A. Orlando, and M.G. Farquhar Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex Proc. Natl. Acad. Sci. U.S.A. 90 1993 4082 4086 (Pubitemid 23134170)
24. M. Oroszlán, M. Bieri, N. Ligeti, A. Farkas, B. Meier, H.P. Marti, and P. Mohacsi Sirolimus and everolimus reduce albumin endocytosis in proximal tubule cells via an angiotensin II-dependent pathway Transpl. Immunol. 23 2010 125 132
25. J.W. Park, E.H. Bae, I.J. Kim, S.K. Ma, C. Choi, J. Lee, and S.W. Kim Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats Am. J. Physiol. Renal Physiol. 298 2010 F301 F313
26. M.J. Pinho, J.M. Cabral, E. Silva, M.P. Serrão, and P. Soares-da-Silva LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing Mol. Cell. Biochem. 349 2011 107 116
27. M.J. Ryan, G. Johnson, J. Kirk, S.M. Fuerstenberg, R.A. Zager, and B. Torok-Storb HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney Kidney Int. 45 1994 48 57 (Pubitemid 24045991)
28. 1) J. Pharmacol. Exp. Ther. 238 1986 1071 1076 (Pubitemid 16033251)
29. M. Sastrasinh, T.C. Knauss, J.M. Weinberg, and H.D. Humes Identification of the aminoglycoside binding site in rat renal brush border membranes J. Pharmacol. Exp. Ther. 222 1982 350 358 (Pubitemid 12047263)
30. J. Schacht Isolation of an aminoglycoside receptor from guinea pig inner ear tissues and kidney Arch. Otorhinolaryngol. 224 1979 129 134 (Pubitemid 9254382)
31. C. Schmitz, J. Hilpert, C. Jacobsen, C. Boensch, E.I. Christensen, F.C. Luft, and T.E. Willnow Megalin deficiency offers protection from renal aminoglycoside accumulation J. Biol. Chem. 277 2002 618 622 (Pubitemid 34952099)
32. H. Servais, A. Ortiz, O. Devuyst, S. Denamur, P.M. Tulkens, and M.P. Mingeot-Leclercq Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation Apoptosis 13 2008 11 32
33. R.S. Stepanyan, A.A. Indzhykulian, A.C. Vélez-Ortega, E.T. Boger, P.S. Steyger, T.B. Friedman, and G.I. Frolenkov TRPA1-Mediated Accumulation of Aminoglycosides in Mouse Cochlear Outer Hair Cells J. Assoc. Res. Otolaryngol. 12 2011 729 740
34. 1 kidney epithelial cell line J. Pharmacol. Exp. Ther. 268 1994 669 674 (Pubitemid 24085862)
35. K. Tousova, L. Vyklicky, K. Susankova, J. Benedikt, and V. Vlachova Gadolinium activates and sensitizes the vanilloid receptor TRPV1 through the external protonation sites Mol. Cell. Neurosci. 30 2005 207 217 (Pubitemid 41319675)
36. A. Vandewalle, N. Farman, J.P. Morin, J.P. Fillastre, P.Y. Hatt, and J.P. Bonvalet Gentamicin incorporation along the nephron: autoradiographic study on isolated tubules Kidney Int. 19 1981 529 539 (Pubitemid 11120899)
37. A. Watanabe, J. Nagai, Y. Adachi, T. Katsube, Y. Kitahara, T. Murakami, and M. Takano Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists J. Control. Release 95 2004 423 433 (Pubitemid 38340493)
38. R.P. Wedeen, V. Batuman, C. Cheeks, E. Marquet, and H. Sobel Transport of gentamicin in rat proximal tubule Lab. Invest. 48 1983 212 223 (Pubitemid 13144382)
39. Q. Wen, Z. Huang, S.F. Zhou, X.Y. Li, N. Luo, and X.Q. Yu Urinary proteins from patients with nephrotic syndrome alters the signalling proteins regulating epithelial-mesenchymal transition Nephrology (Carlton) 15 2010 63 74
40. +-glucose cotransporters Am. J. Physiol. Renal Physiol. 280 2001 F10 F18
41. R.A. Zager, A.C. Johnson, and A. Geballe Gentamicin suppresses endotoxin-driven TNF-alpha production in human and mouse proximal tubule cells Am. J. Physiol. Renal Physiol. 293 2007 F1373 F1380
42. X.Y. Zhai, R. Nielsen, H. Birn, K. Drumm, S. Mildenberger, R. Freudinger, S.K. Moestrup, P.J. Verroust, E.I. Christensen, and M. Gekle Cubilin- and megalin-mediated uptake of albumin in cultured proximal tubule cells of opossum kidney Kidney Int. 58 2000 1523 1533
43. W. Zhipeng, L. Li, M. Qibing, L. Linna, R. Yuhua, and Z. Rong Increased expression of heat shock protein (HSP)72 in a human proximal tubular cell line (HK-2) with gentamicin-induced injury J. Toxicol. Sci. 31 2006 61 70 (Pubitemid 43375669)