LAT1 overexpression and function compensates downregulation of ASCT2 in an in vitro model of renal proximal tubule cell ageing

Molecular and Cellular Biochemistry

Volumn 349, Issue 1-2, 2011, Pages 107-116

  Pinho, Maria João ^a   Cabral, José Miguel ^a   Silva, Elisabete ^a   Serrão, Maria Paula ^a   Soares Da Silva, Patrício ^a  

^a Institute of Pharmacology and Therapeutics   (Portugal)

Author keywords

Amino acid transporters; ASCT2; In vitro cellular ageing; Kidney; LAT1

Indexed keywords

ALANINE; AMINO ACID TRANSPORTER; LAT 1 PROTEIN; LEUCINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL AGING; CONTROLLED STUDY; DOWN REGULATION; FETUS; IN VITRO STUDY; KIDNEY PROXIMAL TUBULE; NONHUMAN; POLYPLOIDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALANINE; AMINO ACID TRANSPORT SYSTEM ASC; AMINO ACIDS, CYCLIC; ANIMALS; ANTIGENS, CD98 HEAVY CHAIN; CELL AGING; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; KIDNEY TUBULES, PROXIMAL; KINETICS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; LEUCINE; OPOSSUMS; POLYPLOIDY; SUBCELLULAR FRACTIONS;

DIDELPHIDAE;

EID: 79952282493     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0665-5     Document Type: Article

References (48)

1. M Palacin R Estevez J Bertran A Zorzano 1998 Molecular biology of mammalian plasma membrane amino acid transporters Physiol Rev 78 4 969 1054 1:CAS:528:DyaK1cXntFOhurg%3D 9790568 (Pubitemid 28491947)
2. F Verrey L System 2003 Heteromeric exchangers of large, neutral amino acids involved in directional transport Pflugers Arch 445 5 529 533 1:CAS:528:DC%2BD3sXjt1Ggu7w%3D 12634921 (Pubitemid 36286884)
3. CA Wagner F Lang S Broer 2001 Function and structure of heterodimeric amino acid transporters Am J Physiol Cell Physiol 281 4 C1077 C1093 1:CAS:528:DC%2BD3MXnsFSlt7g%3D 11546643
4. Y Kanai H Endou 2001 Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance Curr Drug Metab 2 4 339 354 1:CAS:528:DC%2BD3MXptVeit7g%3D 10.2174/1389200013338324 11766986 (Pubitemid 33133979)
5. L Mastroberardino B Spindler R Pfeiffer PJ Skelly J Loffing CB Shoemaker F Verrey 1998 Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family Nature 395 6699 288 291 1:CAS:528:DyaK1cXmtFejsb4%3D 10.1038/26246 9751058 (Pubitemid 28447555)
6. M Palacin G Borsani G Sebastio 2001 The molecular bases of cystinuria and lysinuric protein intolerance Curr Opin Genet Dev 11 3 328 335 1:CAS:528:DC%2BD3MXktFyisr8%3D 10.1016/S0959-437X(00)00198-2 11377971 (Pubitemid 32480301)
7. F Verrey Z Ristic E Romeo T Ramadan V Makrides MH Dave CA Wagner SM Camargo 2005 Novel renal amino acid transporters Annu Rev Physiol 67 557 572 1:CAS:528:DC%2BD2MXjsFeks74%3D 10.1146/annurev.physiol.67.031103.153949 15709970 (Pubitemid 40404501)
8. XJ Zhou D Rakheja X Yu R Saxena ND Vaziri FG Silva 2008 The aging kidney Kidney Int 74 6 710 720 1:CAS:528:DC%2BD1cXhtVGgtbjM 10.1038/ki.2008.319 18614996
9. A Melk ES Mansfield SC Hsieh T Hernandez-Boussard P Grimm DC Rayner PF Halloran MM Sarwal 2005 Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling Kidney Int 68 6 2667 2679 1:CAS:528:DC%2BD28XhslSqtw%3D%3D 10.1111/j.1523-1755.2005.00738.x 16316342 (Pubitemid 43251012)
10. EM Blalock NM Porter PW Landfield 1999 Decreased G-protein-mediated regulation and shift in calcium channel types with age in hippocampal cultures J Neurosci 19 19 8674 8684 1:CAS:528:DyaK1MXmt1ejsbw%3D 10493768 (Pubitemid 30226786)
11. W Huang B Carlsen GH Rudkin N Shah C Chung K Ishida DT Yamaguchi TA Miller 2001 Effect of serial passage on gene expression in MC3T3-E1 preosteoblastic cells: a microarray study Biochem Biophys Res Commun 281 5 1120 1126 1:CAS:528:DC%2BD3MXhslSmsrw%3D 10.1006/bbrc.2001.4458 11243851 (Pubitemid 32924536)
12. SK Moon BY Cha CH Kim 2003 In vitro cellular aging is associated with enhanced proliferative capacity, G1 cell cycle modulation, and matrix metalloproteinase-9 regulation in mouse aortic smooth muscle cells Arch Biochem Biophys 418 1 39 48 1:CAS:528:DC%2BD3sXnt1ygsbo%3D 10.1016/S0003-9861(03)00402-8 13679081 (Pubitemid 37138492)
13. 2+]i signalling in rat cerebellar granule neurones aged in vitro Neurobiol Aging 25 3 349 359 1:CAS:528: DC%2BD2cXhtV2ktrY%3D 10.1016/S0197-4580(03)00123-4 15123341 (Pubitemid 38220971)
14. JM Arthur 2000 The MDCK cell line is made up of populations of cells with diverse resistive and transport properties Tissue Cell 32 5 446 450 1:STN:280:DC%2BD3M7ptF2qsw%3D%3D 10.1054/tice.2000.0135 11201284
15. DM Cottam MJ Milner 1997 Effect of age on the growth and response of a drosophila cell line to moulting hormone Tissue Cell 29 6 727 732 1:CAS:528:DyaK1cXpslahsw%3D%3D 10.1016/S0040-8166(97)80048-1 9467932 (Pubitemid 28040837)
16. H Yu TJ Cook PJ Sinko 1997 Evidence for diminished functional expression of intestinal transporters in Caco-2 cell monolayers at high passages Pharm Res 14 6 757 762 1:CAS:528:DyaK2sXkt1yit7Y%3D 10.1023/A:1012150405949 9210193 (Pubitemid 27281670)
17. P Gomes J Xu P Serrao S Doria PA Jose P Soares-da-Silva 2002 Expression and function of sodium transporters in two opossum kidney cell clonal sublines Am J Physiol Renal Physiol 283 1 F73 F85 1:CAS:528:DC%2BD38XlsVCktbw%3D 12060589
18. H Koyama C Goodpasture MM Miller RL Teplitz AD Riggs 1978 Establishment and characterization of a cell line from the American opossum (Didelphys virginiana) In Vitro 14 3 239 246 1:STN:280:DyaE1c3hslShtA%3D%3D 10.1007/BF02616032 566717 (Pubitemid 8334089)
19. +-ATPase in opossum kidney cells Am J Physiol Regul Integr Comp Physiol 293 4 R1764 R1770 1:CAS:528:DC%2BD2sXht1Wlu7vK 17670864
20. +-ATPase in opossum kidney cells J Cell Physiol 221 2 318 324 1:CAS:528:DC%2BD1MXhtVGrsr3I 10.1002/jcp.21853 19582774
21. +-dependent neutral amino acid transporter ASCT2 in the spontaneously hypertensive rat kidney Am J Physiol Regul Integr Comp Physiol 293 1 R538 R547 1:CAS:528:DC%2BD2sXovVygsLg%3D 17475673
22. MJ Pinho MP Serrao PA Jose P Soares-da-Silva 2007 Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat Cell Physiol Biochem 20 5 535 548 1:CAS:528:DC%2BD2sXps1Sgt7o%3D 10.1159/000107537 17762180 (Pubitemid 47340614)
23. MM Bradford 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 248 254 1:CAS:528:DyaE28XksVehtrY%3D 10.1016/0003-2697(76)90527- 3 942051
24. A Abdolzade-Bavil S Hayes L Goretzki M Kroger J Anders R Hendriks 2004 Convenient and versatile subcellular extraction procedure, that facilitates classical protein expression profiling and functional protein analysis Proteomics 4 5 1397 1405 1:CAS:528:DC%2BD2cXktFChsr0%3D 10.1002/pmic.200300710 15188407 (Pubitemid 38648028)
25. Motulsky HJ (1999) Analyzing data with graphpad prism, version 3.0 edn. GraphPad Prism Software, San Diego
26. PD Prasad H Wang W Huang R Kekuda DP Rajan FH Leibach V Ganapathy 1999 Human LAT1, a subunit of system l amino acid transporter: molecular cloning and transport function Biochem Biophys Res Commun 255 2 283 288 1:CAS:528: DyaK1MXhsVShsb8%3D 10.1006/bbrc.1999.0206 10049700 (Pubitemid 29292251)
27. 1 cells Am J Physiol 267 4 Pt 1 C1119 C1129 1:CAS:528:DyaK2cXmvFOlur4%3D 7943275
28. FV Sepulveda JD Pearson 1982 Characterization of neutral amino acid uptake by cultured epithelial cells from pig kidney J Cell Physiol 112 2 182 188 1:CAS:528:DyaL38XkvV2ms70%3D 10.1002/jcp.1041120205 7119020 (Pubitemid 12097385)
29. M Palmada A Speil S Jeyaraj C Bohmer F Lang 2005 The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2 Biochem Biophys Res Commun 331 1 272 277 1:CAS:528:DC%2BD2MXjsFChtrc%3D 10.1016/j.bbrc.2005.03.159 15845389 (Pubitemid 40545172)
30. TE Johnson DR Umbenhauer R Hill C Bradt SN Mueller EM Levine WW Nichols 1992 Karyotypic and phenotypic changes during in vitro aging of human endothelial cells J Cell Physiol 150 1 17 27 10.1002/jcp.1041500104 1:CAS:528:DyaK38XotFSrtg%3D%3D 10.1002/jcp.1041500104 1309825
31. DJ McCrann D Yang H Chen S Carroll K Ravid 2009 Upregulation of NOX4 in the aging vasculature and its association with smooth muscle cell polyploidy Cell Cycle 8 6 902 908 7900[pii] 1:CAS:528:DC%2BD1MXlvFWisLo%3D 10.4161/cc.8.6.7900 19221493
32. NJ Ganem D Pellman 2007 Limiting the proliferation of polyploid cells Cell 131 3 437 440 S0092-8674(07)01342-6[pii]10.1016/j.cell.2007.10.024 1:CAS:528:DC%2BD2sXhtlWitr7F 10.1016/j.cell.2007.10.024 17981108 (Pubitemid 350007703)
33. NM Borradaile JG Pickering 2010 Polyploidy impairs human aortic endothelial cell function and is prevented by nicotinamide phosphoribosyltransferase Am J Physiol Cell Physiol 298 1 C66 C74 ajpcell.00357.2009[pii]10.1152/ajpcell.00357.2009 1:CAS:528:DC%2BC3cXhsFKmtr8%3D 10.1152/ajpcell.00357.2009 19846757
34. D Yang DJ McCrann H Nguyen C St Hilaire RA DePinho MR Jones K Ravid 2007 Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence Aging Cell 6 2 257 260 ACE274[pii]10.1111/j.1474- 9726.2007.00274.x 1:CAS:528:DC%2BD2sXksVWlurY%3D 10.1111/j.1474-9726.2007.00274. x 17291294 (Pubitemid 46455069)
35. V D'Angiolella C Santarpia D Grieco 2007 Oxidative stress overrides the spindle checkpoint Cell Cycle 6 5 576 579 3934[pii] 10.4161/cc.6.5.3934 17351333 (Pubitemid 46440431)
36. GR Gorla H Malhi S Gupta 2001 Polyploidy associated with oxidative injury attenuates proliferative potential of cells J Cell Sci 114 Pt 16 2943 2951 1:CAS:528:DC%2BD3MXmvFCqsL0%3D 11686298 (Pubitemid 32821533)
37. DJ McCrann HG Nguyen MR Jones K Ravid 2008 Vascular smooth muscle cell polyploidy: an adaptive or maladaptive response? J Cell Physiol 215 3 588 592 10.1002/jcp.21363 1:CAS:528:DC%2BD1cXlvVKgt7o%3D 10.1002/jcp.21363 18181174 (Pubitemid 351632679)
38. S Broer 2002 Adaptation of plasma membrane amino acid transport mechanisms to physiological demands Pflugers Arch 444 4 457 466 1:CAS:528:DC%2BD38XlsVeqtbo%3D 10.1007/s00424-002-0840-y 12136264 (Pubitemid 35461788)
39. MJ Pinho MP Serrao P Soares-da-Silva 2007 High-salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats Am J Physiol Renal Physiol 292 5 F1452 F1463 00465.2006[pii]10.1152/ajprenal.00465. 2006 1:CAS:528:DC%2BD2sXlslShurk%3D 10.1152/ajprenal.00465.2006 17264310 (Pubitemid 46701873)
40. 0, a neutral amino acid transporter related to Hartnup disorder J Biol Chem 279 23 24467 24476 1:CAS:528:DC%2BD2cXksV2itL8%3D 10.1074/jbc.M400904200 15044460 (Pubitemid 38725311)
41. HN Christensen 1990 Role of amino acid transport and countertransport in nutrition and metabolism Physiol Rev 70 1 43 77 1:CAS:528:DyaK3cXpsF2hsQ%3D%3D 2404290 (Pubitemid 20037281)
42. Y Kanai H Segawa K Miyamoto H Uchino E Takeda H Endou 1998 Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98) J Biol Chem 273 37 23629 23632 1:CAS:528:DyaK1cXmtFOktLo%3D 10.1074/jbc.273.37.23629 9726963 (Pubitemid 28435687)
43. +-ATPase parallels the increase in sodium transport and potassium recycling in an in vitro model of proximal tubule cellular ageing J Membr Biol 212 3 163 175 1:CAS:528:DC%2BD2sXis1KlsLk%3D 10.1007/s00232-005-7017- 5 17334838 (Pubitemid 46395787)
44. J Sang YP Lim M Panzica P Finch NL Thompson 1995 TA1, a highly conserved oncofetal complementary DNA from rat hepatoma, encodes an integral membrane protein associated with liver development, carcinogenesis, and cell activation Cancer Res 55 5 1152 1159 1:CAS:528:DyaK2MXktVGiurc%3D 7532544
45. BT Storey C Fugere A Lesieur-Brooks C Vaslet NL Thompson 2005 Adenoviral modulation of the tumor-associated system l amino acid transporter, LAT1, alters amino acid transport, cell growth and 4F2/CD98 expression with cell-type specific effects in cultured hepatic cells Int J Cancer 117 3 387 397 1:CAS:528:DC%2BD2MXhtFant7rL 10.1002/ijc.21169 15900591 (Pubitemid 41429562)
46. DA Wolf S Wang MA Panzica NH Bassily NL Thompson 1996 Expression of a highly conserved oncofetal gene, TA1/E16, in human colon carcinoma and other primary cancers: homology to schistosoma mansoni amino acid permease and Caenorhabditis elegans gene products Cancer Res 56 21 5012 5022 1:CAS:528:DyaK28XmsFygt7g%3D 8895758 (Pubitemid 26374443)
47. O Yanagida Y Kanai A Chairoungdua DK Kim H Segawa T Nii SH Cha H Matsuo J Fukushima Y Fukasawa Y Tani Y Taketani H Uchino JY Kim J Inatomi I Okayasu K Miyamoto E Takeda T Goya H Endou 2001 Human l-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines Biochim Biophys Acta 1514 2 291 302 1:CAS:528:DC%2BD3MXms1Olsb4%3D 10.1016/S0005- 2736(01)00384-4 11557028 (Pubitemid 32831016)
48. BC Fuchs BP Bode 2005 Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime? Semin Cancer Biol 15 4 254 266 1:CAS:528:DC%2BD2MXmvVKntLY%3D 10.1016/j.semcancer.2005.04.005 15916903 (Pubitemid 41065034)