Neuroimaging, biochemical and cellular evidence of protection by mycophenolate mofetil on middle cerebral artery occlusion induced injury in rats

European Journal of Pharmacology

Volumn 684, Issue 1-3, 2012, Pages 71-78

  Chauhan, Anjali ^a   Sharma, Uma ^a   Reeta, K H ^a   Jagannathan, N R ^a   Mehra, R D ^a   Gupta, Yogendra Kumar ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Middle cerebral artery occlusion; Mycophenolate mofetil; Neuroprotection; Stroke

Indexed keywords

GLUTATHIONE; MALONALDEHYDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYELOPEROXIDASE; NITRIC OXIDE;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CELL PROTECTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; DRUG EFFICACY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROIMAGING; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; GLUTATHIONE; HAND STRENGTH; INFARCTION, MIDDLE CEREBRAL ARTERY; MAGNETIC RESONANCE IMAGING; MALE; MALONDIALDEHYDE; MYCOPHENOLIC ACID; NEUROIMAGING; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; REPERFUSION INJURY; ROTAROD PERFORMANCE TEST;

EID: 84860835838     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.03.037     Document Type: Article

References (47)

1. N. Ahrens, A. Salama, and J. Haas Mycophenolate-mofetil in the treatment of refractory multiple sclerosis J. Neurol. 248 2001 713 714 (Pubitemid 32695873)
2. A.C. Allison, and E.M. Eugui Mycophenolate mofetil and its mechanisms of action Immunopharmacology 47 2000 85 118 (Pubitemid 30394534)
3. C. Behn, O.F. Araneda, A.J. Llanos, G. Celedón, and G. González Hypoxia-related lipid peroxidation: evidences, implications and approaches Respir. Physiol. Neurobiol. 158 2007 143 150 (Pubitemid 47432872)
4. A. Betz, and W. Dietrich Blood-brain barrier: dysfunction in cerebral ischemia M. Ginsberg, J. Bogousslavsky, Cerebrovascular Disease: Pathophysiology, Diagnosis and Management 1998 Blackwell Science Philadelphia, Pa 358 370
5. B. Bilginer, M.B. Onal, F. Narin, H. Ustun, K. Kilinc, and N. Akalan Antiapoptotic and neuroprotective effects of mycophenolate mofetil after acute spinal cord injury in young rats Childs Nerv. Syst. 25 2009 1555 1561
6. Y. Bravo, Y. Quiroz, A. Ferrebuz, N.D. Vaziri, and B. Rodríguez-Iturbe Mycophenolate mofetil administration reduces renal inflammation, oxidative stress, and arterial pressure in rats with lead-induced hypertension Am. J. Physiol. Renal Physiol. 293 2007 F616 F623
7. M.O. Breckwoldt, J.W. Chen, L. Stangenberg, E. Aikawa, E. Rodriguez, S. Qiu, M.A. Moskowitz, and R. Weissleder Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase Proc. Natl. Acad. Sci. U. S. A. 105 2008 18584 18589
8. G. Chaudhary, K. Sinha, and Y.K. Gupta Protective effect of exogenous administration of alpha-tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats Fundam. Clin. Pharmacol. 17 2003 703 707 (Pubitemid 37491557)
9. V. Chaudhry, D.R. Cornblath, J.W. Griffin, R. O'Brien, and D.B. Drachman Mycophenolate mofetil: a safe and promising immunosuppressant in neuromuscular diseases Neurology 56 2001 94 96 (Pubitemid 32059658)
10. A.M. de Mattos, A.J. Olyaei, and W.M. Bennett Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future Am. J. Kidney Dis. 35 2000 333 346 (Pubitemid 30070861)
11. F. Dehghani, G.T. Hischebeth, F. Wirjatijasa, A. Kohl, H.W. Korf, and N.P. Hailer The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures Eur. J. Neurosci. 18 2003 1061 1072 (Pubitemid 37115028)
12. G.A. Donnan, M. Fisher, M. Macleod, and S.M. Davis Stroke Lancet 371 2008 1612 1623 (Pubitemid 351626845)
13. G.L. Ellman Tissue sulfhydryl groups Arch. Biochem. Biophys. 82 1959 70 77
14. Y.K. Gupta, and S. Briyal Animal models of cerebral ischemia for evaluation of drugs Indian J. Physiol. Pharmacol. 48 2004 379 394 (Pubitemid 39390002)
15. Y.K. Gupta, K. Sinha, G. Chaudhary, and N.R. Jagannathan Protective effect of adenosine against neuronal injury induced by middle cerebral artery occlusion in rats as evidenced by diffusion-weighted imaging Pharmacol. Biochem. Behav. 72 2002 569 574 (Pubitemid 34450857)
16. Y.K. Gupta, S. Briyal, U. Sharma, N.R. Jagannathan, and A. Gulati Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats Life Sci. 77 2005 15 27 (Pubitemid 40546373)
17. W. Hacke, M. Kaste, E. Bluhmki, M. Brozman, A. Dávalos, D. Guidetti, V. Larrue, K.R. Lees, Z. Medeghri, T. Machnig, D. Schneider, R. von Kummer, N. Wahlgren, D. Toni ECASS Investigators Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke N. Engl. J. Med. 359 2008 1317 1329
18. M. Hoehn-Berlage, D.G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K.A. Hossmann Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances J. Cereb. Blood Flow Metab. 15 1995 1002 1011
19. C. Iadecola, F. Zhang, S. Xu, R. Casey, and M.E. Ross Inducible nitric oxide synthase gene expression in brain following cerebral ischemia J. Cereb. Blood Flow Metab. 15 1995 378 384
20. S.P. Janssen, M. Phernambucq, P. Martinez-Martinez, M.H. De Baets, and M. Losen Immunosuppression of experimental autoimmune myasthenia gravis by mycophenolate mofetil J. Neuroimmunol. 201-202 2008 111 120
21. J. Koizumi, Y. Yoshida, T. Nazakawa, and G. Ooneda Experimental studies of ischemic bran edema: a new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemic area Jpn. J. Stroke 8 1986 1 8
22. F. Liu, D.P. Schafer, and L.D. McCullough TTC, fluoro-Jade B and NeuN staining confirm evolving phases of infarction induced by middle cerebral artery occlusion J. Neurosci. Methods 179 2009 1 8
23. Y.X. Liu, L.M. Jin, L. Zhou, H.Y. Xie, G.P. Jiang, Y. Wang, X.W. Feng, H. Chen, S. Yan, and S.S. Zheng Mycophenolate mofetil attenuates liver ischemia/reperfusion injury in rats Transpl. Int. 22 2009 747 756
24. E.H. Lo, A.R. Pierce, J.B. Mandeville, and B.R. Rosen Neuroprotection with NBQX in rat focal cerebral ischemia. Effects on ADC probability distribution functions and diffusion-perfusion relationships Stroke 28 1997 439 446
25. S.L. Lui, and P.F. Halloran Mycophenolate mofetil in kidney transplantation Curr. Opin. Nephrol. Hypertens. 5 1996 508 513 (Pubitemid 27055256)
26. S.L. Lui, L.Y. Chan, X.H. Zhang, W. Zhu, T.M. Chan, P.C. Fung, and K.N. Lai Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury Nephrol. Dial. Transplant. 16 2001 1577 1582 (Pubitemid 32750448)
27. M.P. Mattson, C. Culmsee, and Z.F. Yu Apoptotic and antiapoptotic mechanisms in stroke Cell Tissue Res. 301 2000 173 187 (Pubitemid 30459864)
28. R.D. Mehra, K. Sharma, C. Nyakas, and U. Vij Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study Brain Res. 1056 2005 22 35 (Pubitemid 41219354)
29. P.M. Moran, L.S. Higgins, B. Cordell, and P.C. Moser Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein Proc. Natl. Acad. Sci. U. S. A. 92 1995 5341 5345
30. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal. Biochem. 95 1979 351 358 (Pubitemid 9194347)
31. J.W. Phillis, and M.H. O'Regan The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries Crit. Rev. Neurobiol. 15 2003 61 90 (Pubitemid 37101546)
32. A.M. Rao, J.F. Hatcher, M.S. Kindy, and R.J. Dempsey Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils Neurochem. Res. 24 1999 1225 1232 (Pubitemid 29420268)
33. G. Re, G. Azzimondi, C. Lanzarini, L. Bassein, I. Vaona, and C. Guarnieri Plasma lipoperoxidative markers in ischaemic stroke suggest brain embolism Eur. J. Emerg. Med. 4 1997 5 9
34. D.C. Rogers, C.A. Campbell, J.L. Stretton, and K.B. Mackay Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat Stroke 28 1997 2060 2065
35. T.D. Rozen Complete but transient relief of chronic cluster headache with mycophenolate mofetil Headache 44 2004 818 820 (Pubitemid 39310969)
36. S.Y. Saad, M.M. Arafah, and T.A. Najjar Effects of mycophenolate mofetil on cisplatin-induced renal dysfunction in rats Cancer Chemother. Pharmacol. 59 2007 455 460 (Pubitemid 46122323)
37. J. Sharkey, and S.P. Butcher Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia Nature 371 1994 336 339 (Pubitemid 24300615)
38. Y. Shiga, H. Onodera, Y. Matsuo, and K. Kogure Cyclosporin A protects against ischemia-reperfusion injury in the brain Brain Res. 595 1992 145 148
39. K. Sinha, M.N. Degaonkar, N.R. Jagannathan, and Y.K. Gupta Effect of melatonin on ischemia reperfusion injury induced by middle cerebral artery occlusion in rats Eur. J. Pharmacol. 428 2001 185 192 (Pubitemid 33000140)
40. K. Sinha, G. Chaudhary, and Y.K. Gupta Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats Life Sci. 71 2002 655 665 (Pubitemid 34628827)
41. J.H. Sung, D.M. Chao, and Y. Xia Neuronal responses to hypoxia Q. Wang, W.H. Ying, New Frontiers in Neurological Research 2008 Research Signpost Kerala, India 73 153
42. K. Suzuki, H. Ota, S. Sasagawa, T. Sakatani, and T. Fujikura Assay method for myeloperoxidase in human polymorphonuclear leukocytes Anal. Biochem. 132 1983 345 352 (Pubitemid 13048589)
43. T. Tatlisumak, R.A. Carano, K. Takano, T.J. Opgenorth, C.H. Sotak, and M. Fisher A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study Stroke 29 1998 850 857
44. B. Tunçtan, O. Uludag, S. Altug, and N. Abacioglu Effects of nitric oxide synthase inhibition in lipopolysaccharide-induced sepsis in mice Pharmacol. Res. 38 1998 405 411 (Pubitemid 28515514)
45. R.M. Weston, N.M. Jones, B. Jarrott, and J.K. Callaway Inflammatory cell infiltration after endothelin-1-induced cerebral ischemia: histochemical and myeloperoxidase correlation with temporal changes in brain injury J. Cereb. Blood Flow Metab. 27 2007 100 114 (Pubitemid 46006588)
46. J. Yan, L. Xu, A.M. Welsh, D. Chen, T. Hazel, K. Johe, and V.E. Koliatsos Combined immunosuppressive agents or CD4 antibodies prolong survival of human neural stem cell grafts and improve disease outcomes in amyotrophic lateral sclerosis transgenic mice Stem Cells 24 2006 1976 1985 (Pubitemid 44474174)
47. M. Zhuo, D.M. Holtzman, Y. Li, H. Osaka, J. DeMaro, M. Jacquin, and G. Bu Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation J. Neurosci. 20 2000 542 549 (Pubitemid 30225556)