Mycophenolate mofetil attenuates liver ischemia/reperfusion injury in rats

Transplant International

Volumn 22, Issue 7, 2009, Pages 747-756

  Liu, Yuan Xing ^a,b   Jin, Li Ming ^a,b   Zhou, Lin ^a,b   Xie, Hai Yang ^a,b   Jiang, Guo Ping ^a,b   Wang, Yan ^a,b   Feng, Xiao Wen ^a,b   Chen, Hui ^a,b   Yan, Sheng ^c   Zheng, Shu Sen ^a,b,c  

^a BEIJING HOSPITAL   (China)

^b KEY LABORATORY OF ORGAN TRANSPLANTATION   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Ischemia reperfusion injury; Microcirculation; Mitogen activated protein kinases; Mycophenolate mofetil; Reactive oxygen species

Indexed keywords

ASPARTATE AMINOTRANSFERASE; MALONALDEHYDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; MYELOPEROXIDASE; VASCULAR CELL ADHESION MOLECULE 1; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL INTERACTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ASSAY; FLUORESCENCE MICROSCOPY; HEMODYNAMICS; LEUKOCYTE; LEUKOCYTE ADHERENCE; LEUKOCYTE COUNT; LIVER CELL; LIVER CIRCULATION; LIVER FUNCTION; LIVER ISCHEMIA; LIVER PERFUSION; MALE; MICROCIRCULATION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TISSUE LEVEL;

ANIMALS; APOPTOSIS; ENDOTHELIAL CELLS; ENZYME INHIBITORS; LEUKOCYTES; LIVER; MALE; MAP KINASE SIGNALING SYSTEM; MICROCIRCULATION; MICROSCOPY, FLUORESCENCE; MYCOPHENOLIC ACID; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REPERFUSION INJURY;

EID: 66949114994     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2009.00866.x     Document Type: Article

References (51)

1. Totsuka E, Fung U, Hakamada K, et al. Analysis of clinical variables of donors and recipients with respect to short-term graft outcome in human liver transplantation. Transplant Proc 2004 36 : 2215.
2. Fernandez L, Heredia N, Grande L, et al. Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine/xanthine oxidase. Hepatology 2002 36 : 562.
3. El-Badry AM, Moritz W, Contaldo C, Tian Y, Graf R, Clavien PA. Prevention of reperfusion injury and microcirculatory failure in macrosteatotic mouse liver by omega-3 fatty acids. Hepatology 2007 45 : 855.
4. Burkhardt M, Slotta JE, Garcia P, Seekamp A, Menger MD, Pohlemann T. The effect of estrogen on hepatic microcirculation after ischemia/reperfusion. Int J Colorectal Dis 2008 23 : 113.
5. Matsuda T, Yamaguchi Y, Matsumura F, et al. Immunosuppressants decrease neutrophil chemoattractant and attenuate ischemia/reperfusion injury of the liver in rats. J Trauma 1998 44 : 475.
6. Crenesse D, Laurens M, Heurteaux C, et al. Rat liver ischemia- reperfusion-induced apoptosis and necrosis are decreased by FK506 pretreatment. Eur J Pharmacol 2003 473 : 177.
7. Frink M, Kaudel CP, Hildebrand F, et al. FTY720 improves survival after transient ischemia and reperfusion of the hind limbs. J Trauma 2007 63 : 263.
8. Halloran P, Mathew T, Tomlanovich S, Groth C, Hooftman L, Barker C. Mycophenolate mofetil in renal allograft recipients: a pooled efficacy analysis of three randomized, double-blind, clinical studies in prevention of rejection. The International Mycophenolate Mofetil Renal Transplant Study Groups. Transplantation 1997 63 : 39.
9. Fraser-Smith EB, Rosete JD, Schatzman RC. Suppression by mycophenolate mofetil of the neointimal thickening caused by vascular injury in a rat arterial stenosis model. J Pharmacol Exp Ther 1995 275 : 1204.
10. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985 312 : 159.
11. Peralta C, Bulbena O, Xaus C, et al. Ischemic preconditioning: a defense mechanism against the reactive oxygen species generated after hepatic ischemia reperfusion. Transplantation 2002 73 : 1203.
12. Leon Fernandez OS, Ajamieh HH, Berlanga J, et al. Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion. Transpl Int 2008 21 : 39.
13. Bes S, Tatou E, Vandroux D, Tissier C, Rochette L, Athias P. Physiological and metabolic actions of mycophenolate mofetil on cultured newborn rat cardiomyocytes in normoxia and in simulated ischemia. Fundam Clin Pharmacol 2004 18 : 287.
14. Laurent AF, Dumont S, Poindron P, Muller CD. Mycophenolic acid suppresses protein N-linked glycosylation in human monocytes and their adhesion to endothelial cells and to some substrates. Exp Hematol 1996 24 : 59.
15. Ventura CG, Coimbra TM, de Campos SB, de Castro I, Yu L, Seguro AC. Mycophenolate mofetil attenuates renal ischemia/reperfusion injury. J Am Soc Nephrol 2002 13 : 2524.
16. Olschewski P, Hunold G, Eipel C, et al. Improved microcirculation by low-viscosity histidine- tryptophan-ketoglutarate graft flush and subsequent cold storage in University of Wisconsin solution: results of an orthotopic rat liver transplantation model. Transpl Int 2008 21 : 1175.
17. Wiesner R, Rabkin J, Klintmalm G, et al. A randomized double-blind comparative study of mycophenolate mofetil and azathioprine in combination with cyclosporine and corticosteroids in primary liver transplant recipients. Liver Transpl 2001 7 : 442.
18. Fisher RA, Stone JJ, Wolfe LG, et al. Four-year follow-up of a prospective randomized trial of mycophenolate mofetil with cyclosporine microemulsion or tacrolimus following liver transplantation. Clin Transplant 2004 18 : 463.
19. Ringe B, Braun F, Schutz E, et al. A novel management strategy of steroid-free immunosuppression after liver transplantation: efficacy and safety of tacrolimus and mycophenolate mofetil. Transplantation 2001 71 : 508.
20. Taniguchi M, Uchinami M, Doi K, et al. Edaravone reduces ischemia-reperfusion injury mediators in rat liver. J Surg Res 2007 137 : 69.
21. Selzner M, Rudiger HA, Selzner N, Thomas DW, Sindram D, Clavien PA. Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion. J Hepatol 2002 36 : 218.
22. Man K, Fan ST, Ng IO, Lo CM, Liu CL, Wong J. Prospective evaluation of Pringle maneuver in hepatectomy for liver tumors by a randomized study. Ann Surg 1997 226 : 704.
23. Qian JM, Zhang H, Wu XF, Li GQ, Chen XP, Wu J. Improvement of recipient survival after small size graft liver transplantation in rats with preischemic manipulation or administering antisense against nuclear factor-kappaB. Transpl Int 2007 20 : 784.
24. Klintman D, Li X, Santen S, Schramm R, Jeppsson B, Thorlacius H. p38 mitogen-activated protein kinase-dependent chemokine production, leukocyte recruitment, and hepatocellular apoptosis in endotoxemic liver injury. Ann Surg 2005 242 : 830.
25. Demir S, Inal-Erden M. Pentoxifylline and N-acetylcysteine in hepatic ischemia/reperfusion injury. Clin Chim Acta 1998 275 : 127.
26. Gannon DE, Varani J, Phan SH, et al. Source of iron in neutrophil-mediated killing of endothelial cells. Lab Invest 1987 57 : 37.
27. Ambros JT, Herrero-Fresneda I, Borau OG, Boira JM. Ischemic preconditioning in solid organ transplantation: from experimental to clinics. Transpl Int 2007 20 : 219.
28. Parks DA, Granger DN. Ischemia-reperfusion injury: a radical view. Hepatology 1988 8 : 680.
29. Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia/reperfusion-induced granulocyte infiltration. Am J Physiol 1990 258 : G185.
30. Hager PW, Collart FR, Huberman E, Mitchell BS. Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding. Biochem Pharmacol 1995 49 : 1323.
31. Allison AC, Eugui EM. Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF). Clin Transplant 1996 10 : 77.
32. Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000 47 : 85.
33. Puglisi RN, Strande L, Santos M, Schulte G, Hewitt CW, Whalen TV. Beneficial effects of cyclosporine and rapamycin in small bowel ischemic injury. J Surg Res 1996 65 : 115.
34. Grisham MB, Hernandez LA, Granger DN. Xanthine oxidase and neutrophil infiltration in intestinal ischemia. Am J Physiol 1986 251 : G567.
35. Mayumi T, Chan CK, Clemens MG, Bulkley GB. Zonal heterogeneity of hepatic injury following shock/resuscitation: relationship of xanthine oxidase activity to localization of neutrophil accumulation and central lobular necrosis. Shock 1996 5 : 324.
36. Menger MD, Vollmar B. Role of microcirculation in transplantation. Microcirculation 2000 7 : 291.
37. Serafin A, Rosello-Catafau J, Prats N, Xaus C, Gelpi E, Peralta C. Ischemic preconditioning increases the tolerance of Fatty liver to hepatic ischemia-reperfusion injury in the rat. Am J Pathol 2002 161 : 587.
38. Ikeda F, Terajima H, Shimahara Y, Kondo T, Yamaoka Y. Reduction of hepatic ischemia/reperfusion-induced injury by a specific ROCK/Rho kinase inhibitor Y-27632. J Surg Res 2003 109 : 155.
39. Klintman D, Schramm R, Menger MD, Thorlacius H. Leukocyte recruitment in hepatic injury: selectin-mediated leukocyte rolling is a prerequisite for CD18-dependent firm adhesion. J Hepatol 2002 36 : 53.
40. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994 84 : 2068.
41. Dold S, Laschke MW, Lavasani S, Menger MD, Thorlacius H. Cholestatic liver damage is mediated by lymphocyte function antigen-1-dependent recruitment of leukocytes. Surgery 2008 144 : 385.
42. Rajesh M, Pan H, Mukhopadhyay P, et al. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J Leukoc Biol 2007 82 : 1382.
43. Teoh NC, Ito Y, Field J, et al. Diannexin, a novel annexin V homodimer, provides prolonged protection against hepatic ischemia-reperfusion injury in mice. Gastroenterology 2007 133 : 632.
44. Hafez T, Moussa M, Nesim I, Baligh N, Davidson B, Abdul-Hadi A. The effect of intraportal prostaglandin E1 on adhesion molecule expression, inflammatory modulator function, and histology in canine hepatic ischemia/reperfusion injury. J Surg Res 2007 138 : 88.
45. Man K, Ng KT, Lee TK, et al. FTY720 attenuates hepatic ischemia-reperfusion injury in normal and cirrhotic livers. Am J Transplant 2005 5 : 40.
46. Song J, Zhang YW, Yao AH, et al. Adenoviral cardiotrophin-1 transfer improves survival and early graft function after ischemia and reperfusion in rat small-for-size liver transplantation model. Transpl Int 2008 21 : 372.
47. Pandolfi A, Di Pietro N, Sirolli V, et al. Mechanisms of uremic erythrocyte-induced adhesion of human monocytes to cultured endothelial cells. J Cell Physiol 2007 213 : 699.
48. Pietersma A, Tilly BC, Gaestel M, et al. p38 mitogen activated protein kinase regulates endothelial VCAM-1 expression at the post-transcriptional level. Biochem Biophys Res Commun 1997 230 : 44.
49. Tamura DY, Moore EE, Johnson JL, Zallen G, Aiboshi J, Silliman CC. p38 mitogen-activated protein kinase inhibition attenuates intercellular adhesion molecule-1 up-regulation on human pulmonary microvascular endothelial cells. Surgery 1998 124 : 403.
50. Ha H, Kim MS, Park J, et al. Mycophenolic acid inhibits mesangial cell activation through p38 MAPK inhibition. Life Sci 2006 79 : 1561.
51. Gu JJ, Gathy K, Santiago L, et al. Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. Blood 2003 101 : 4958.