The association between plasma homocysteine levels, methylation capacity and incident osteoporotic fractures

Bone

Volumn 50, Issue 6, 2012, Pages 1401-1405

  Enneman, A W ^a   van der Velde, N ^a   de Jonge, R ^a   Heil, S G ^a   Stolk, L ^a,b   Hofman, A ^a   Rivadeneira, F ^a,b   Zillikens, M C ^a,b   Uitterlinden, A G ^a,b   van Meurs, J B J ^a,b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Netherlands Genomics Initiative   (Netherlands)

Author keywords

Fractures; Homocysteine; Osteoporosis; S adenosylhomocysteine; S adenosylmethionine

Indexed keywords

S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BONE DENSITY; COHORT ANALYSIS; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FOLLOW UP; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; POPULATION RESEARCH; PROTEIN METHYLATION; RISK ASSESSMENT; S ADENOSYLHOMOCYSTEINE BLOOD LEVEL; S ADENOSYLMETHIONINE BLOOD LEVEL;

AGED; BONE DENSITY; FEMALE; HOMOCYSTEINE; HUMANS; INCIDENCE; LINEAR MODELS; METHYLATION; MIDDLE AGED; NETHERLANDS; OSTEOPOROTIC FRACTURES; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE;

EID: 84860833630     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.03.013     Document Type: Article

References (34)

1. Anonymous Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1993, 94.
2. Bliuc D., Nguyen N.D., Milch V.E., Nguyen T.V., Eisman J.A., Center J.R. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 2009, 301:513-521.
3. Roth T., Kammerlander C., Gosch M., Luger T.J., Blauth M. Outcome in geriatric fracture patients and how it can be improved. Osteoporos Int 2010, 21:S615-S619.
4. Kanis J.A., Johnell O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos Int 2005, 16:229-238.
5. van Meurs J.B., Dhonukshe-Rutten R.A., Pluijm S.M., van der Klift M., de Jonge R., Lindemans J., et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004, 350:2033-2041.
6. McLean R.R., Jacques P.F., Selhub J., Tucker K.L., Samelson E.J., Broe K.E., et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004, 350:2042-2049.
7. Leboff M.S., Narweker R., LaCroix A., Wu L., Jackson R., Lee J., et al. Homocysteine levels and risk of hip fracture in postmenopausal women. J Clin Endocrinol Metab 2009, 94:1207-1213.
8. Gjesdal C.G., Vollset S.E., Ueland P.M., Refsum H., Drevon C.A., Gjessing H.K., et al. Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med 2006, 166:88-94.
9. Lubec B., Fang-Kircher S., Lubec T., Blom H.J., Boers G.H. Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1996, 1315:159-162.
10. Caudill M.A., Wang J.C., Melnyk S., Pogribny I.P., Jernigan S., Collins M.D., et al. Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr 2001, 131:2811-2818.
11. Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 2000, 275:29318-29323.
12. De La Haba G., Cantoni G.L. The enzymatic synthesis of S-adenosyl-l-homocysteine from adenosine and homocysteine. J Biol Chem 1959, 234:603-608.
13. Herrmann M., Tami A., Wildemann B., Wolny M., Wagner A., Schorr H., et al. Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone 2009, 44:467-475.
14. Hofman A., van Duijn C.M., Franco O.H., Ikram M.A., Janssen H.L., Klaver C.C., et al. The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol 2011, 26:657-686.
15. van Driel L.M., Eijkemans M.J., de Jonge R., de Vries J.H., van Meurs J.B., Steegers E.A., et al. Body mass index is an important determinant of methylation biomarkers in women of reproductive ages. J Nutr 2009, 139:2315-2321.
16. Ducros V., Belva-Besnet H., Casetta B., Favier A. A robust liquid chromatography tandem mass spectrometry method for total plasma homocysteine determination in clinical practice. Clin Chem Lab Med 2006, 44:987-990.
17. Gellekink H., van Oppenraaij-Emmerzaal D., van Rooij A., Struys E.A., den Heijer M., Blom H.J. Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clin Chem 2005, 51:1487-1492.
18. Gjesdal C.G., Vollset S.E., Ueland P.M., Refsum H., Meyer H.E., Tell G.S. Plasma homocysteine, folate, and vitamin B 12 and the risk of hip fracture: the Hordaland Homocysteine Study. J Bone Miner Res 2007, 22:747-756.
19. Villadsen M.M., Bunger M.H., Carstens M., Stenkjaer L., Langdahl B.L. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 2005, 16:411-416.
20. Holstein J.H., Herrmann M., Splett C., Herrmann W., Garcia P., Histing T., et al. High bone concentrations of homocysteine are associated with altered bone morphology in humans. Br J Nutr 2011, 1-5.
21. Vaes B.L., Lute C., van der Woning S.P., Piek E., Vermeer J., Blom H.J., et al. Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone 2010, 46:514-523.
22. Herrmann M., Peter Schmidt J., Umanskaya N., Wagner A., Taban-Shomal O., Widmann T., et al. The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review. Clin Chem Lab Med 2007, 45:1621-1632.
23. Cagnacci A., Bagni B., Zini A., Cannoletta M., Generali M., Volpe A. Relation of folates, vitamin B12 and homocysteine to vertebral bone mineral density change in postmenopausal women. A five-year longitudinal evaluation. Bone 2008, 42:314-320.
24. Haliloglu B., Aksungar F.B., Ilter E., Peker H., Akin F.T., Mutlu N., et al. Relationship between bone mineral density, bone turnover markers and homocysteine, folate and vitamin B12 levels in postmenopausal women. Arch Gynecol Obstet 2010, 281:663-668.
25. Riancho J.A., Valero C., Zarrabeitia M.T. MTHFR polymorphism and bone mineral density: meta-analysis of published studies. Calcif Tissue Int 2006, 79:289-293.
26. Shiraki M., Urano T., Kuroda T., Saito M., Tanaka S., Miyao-Koshizuka M., et al. The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures. J Bone Miner Metab 2008, 26:595-602.
27. Valero C., Alonso M.A., Zarrabeitia M.T., Viadero C., Hernandez J.L., Riancho J.A. MTHFR C677T polymorphism and osteoporotic fractures. Horm Metab Res 2007, 39:543-547.
28. Zhu K., Beilby J., Dick I.M., Devine A., Soos M., Prince R.L. The effects of homocysteine and MTHFR genotype on hip bone loss and fracture risk in elderly women. Osteoporos Int 2009, 20:1183-1191.
29. Jorgensen H.L., Madsen J.S., Madsen B., Saleh M.M., Abrahamsen B., Fenger M., et al. Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case control study in Danish postmenopausal women. Calcif Tissue Int 2002, 71:386-392.
30. Loehrer F.M., Tschopl M., Angst C.P., Litynski P., Jager K., Fowler B., et al. Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease. Atherosclerosis 2001, 154:147-154.
31. Van Hecke M.V., Dekker J.M., Nijpels G., Teerlink T., Jakobs C., Stolk R.P., et al. Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study. Clin Sci (Lond) 2008, 114:479-487.
32. de Boer M.G., van Zelst B., Gelinck L.B., Kroon F.P., de Jonge R. Pneumocystis pneumonia and measurement of S-adenosylmethionine plasma levels. J Infect 2011, 62:493-495.
33. Van Wijngaarden J.P., Dhonukshe-Rutten R.A.M., Van Schoor N.M., Van der Velde N., Swart K.M.A., Enneman A.W., et al. Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence. BMC Geriatr 2011, 11:80.
34. Laboratoriumgids AKC & DLE Last accessed: 30 November 2011. http://www.erasmusmc.nl/akc/Patientenzorg/Professionals/labgids/3295019/.