MTHFR polymorphism and bone mineral density: Meta-analysis of published studies

Calcified Tissue International

Volumn 79, Issue 5, 2006, Pages 289-293

  Riancho, J A ^a   Valero, C ^a   Zarrabeitia, M T ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

Homocysteine; Meta analysis; Methylenetetrahydrofolate reductase; Osteoporosis; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

ALLELE; ARTICLE; BONE DENSITY; CLINICAL STUDY; FEMUR NECK; GENETIC POLYMORPHISM; GENOTYPE; HIP; HUMAN; OSTEOPOROSIS; PRIORITY JOURNAL; SPINE;

BONE DENSITY; FEMALE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 33845444484     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-006-0143-y     Document Type: Article

References (23)

1. Hamerman D (2005) Osteoporosis and atherosclerosis: biological linkages and the emergence of dual-purpose therapies. QJM 98:467-484
2. Jorgensen L, Joakimsen O, Rosvold Berntsen GK, Heuch I, Jacobsen BK (2004) Low bone mineral density is related to echogenic carotid artery plaques: a population-based study. Am J Epidemiol 160:549-556
3. Wald DS, Law M, Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a metaanalysis. BMJ 325:1202-1207
4. Gjesdal CG, Vollset SE, Ueland PM, Refsum H, Drevon CA, Gjessing HK, Tell GS (2006) Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med 166:88-94
5. Golbahar J, Hamidi A, Aminzadeh MA, Omrani GR (2004) Association of plasma folate, plasma total homocysteine, but not methylenetetrahydrofolate reductase C677T polymorphism, with bone mineral density in postmenopausal Iranian women: a cross-sectional study. Bone 33:760-765
6. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, et al. (2004) Homocysteine as a predictive factor for hip fractures in older persons. N Engl J Med 350:2042-2049
7. Van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF, Van der Klift M, de Jonge R, Lindemans J, et al. (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041
8. Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD (2005) Homocysteine and stroke: evidence on a causal link from mendelian randomisation. Lancet 365:224-232
9. Abrahamsen B, Jorgensen HL, Nielsen TL, Andersen M, Haug E, Schwarz P, Hagen C, Brixen K (2006) MTHFR c.677C>T polymorphism as an independent predictor of peak bone mass in Danish men - results from the Odense Androgen Study. Bone 38:215-219
10. MacDonald HM, McGuigan FE, Fraser WD, New SA, Ralston SH, Reid DM (2004) Methylenetetrahydrofolate reductase polymorphism interacts with riboflavin intake to influence bone mineral density. Bone 35:957-964
11. McLean RR, Karasik D, Selhub J, Tucker KL, Ordovas J, Russo GT, Cupples LA, Jacques PF, Kiel D (2004) Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 19:410-418
12. Miyao M, Morita H, Hosoi T, Kurihara H, Inoue S, Hoshimo S, et al. (2000) Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 66:190-194
13. Villadsen MM, Bünger MH, Carstens M, Stenkjaer L, Langdahl BL (2005) Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with osteoporotic vertebral fractures, but is a weak predictor of BMD. Osteoporos Int 16:411-416
14. Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, Weir DG, Scott JM (1997) Thermolabile variant of 5,10- methylenetetrahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 349:1591-1593
15. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L (2003) A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish Osteoporosis Prevention Study. J Bone Miner Res 18:723-729
16. Abrahamsen B, Madsen JS, Tofteng CL, Stilgren L, Bladbjerg EM, Kristensen SR, Brixen K, Mosekilde L (2005) Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish Osteoporosis Prevention Study. Bone 36:577-583
17. Li M, Lau EM, Woo J (2004) Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women. Bone 35:1369-1374
18. Saverino A, Del Sette M, Conti M, Ermirio D, Ricca M, Rovetta G, Gandolfo C (2006) Hyperechoic plaque: an ultrasound marker for osteoporosis in acute stroke patients with carotid disease. Eur Neurol 55:31-36
19. Tanko LB, Christiansen C, Cox DA, Geiger MJ, McNabb MA, Cummings SR (2005) Relationship between osteoporosis and cardiovascular disease in postmenopausal women. J Bone Miner Res 20:1912-1920
20. Wong SY, Kwok T, Woo J, Lynn H, Griffith JF, Leung J, Tang YY, Leung PC (2005) Bone mineral density and the risk of peripheral arterial disease in men and women: results from Mr. and Ms. Os, Hong Kong. Osteoporos Int 16:1933-1938
21. Smith GD, Ebrahim S (2004) Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33:30-42
22. Bathum L, von Bornemann-Hjelmorbg J, Christiansen L, Madsen JS, Skytthe A, Christensen K (2004) Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish study. Osteoporos Int 15:659-664
23. Jorgensen HL, Madsen JS, Madsen B, Saleh MMA, Abrahamsen B, Fenger M, Lauritzen JB (2002) Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures. A case-control study in Danish postmenopausal women. Calcif Tissue Int 71:386-392