Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors

Cell Cycle

Volumn 11, Issue 9, 2012, Pages 1818-1826

  Chang, Li Ju ^a   Eastman, Alan ^a  

^a NORRIS COTTON CANCER CENTER   (United States)

Author keywords

Cell cycle checkpoints; Chk1; MK 8776; p53 response; UCN 01

Indexed keywords

MESSENGER RNA; PROTEIN P21; PROTEIN P53; CAMPTOTHECIN; CDKN1A PROTEIN, HUMAN; CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DRUG DERIVATIVE; IRINOTECAN; MK 8776; MK-8776; PROTEIN KINASE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; RNA; TP53 PROTEIN, HUMAN;

ARTICLE; CANCER CELL CULTURE; CELL LINE; CELL STRAIN HCT116; COLORECTAL CARCINOMA; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MUTATION; OSTEOSARCOMA CELL; POLYSOME; PROTEIN EXPRESSION; PROTEIN INDUCTION; RNA TRANSLATION; WILD TYPE; CELL CYCLE CHECKPOINT; DNA DAMAGE; GENE EXPRESSION REGULATION; GENETICS; HALF LIFE TIME; KINETICS; METABOLISM; PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

CAMPTOTHECIN; CELL CYCLE CHECKPOINTS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HALF-LIFE; HCT116 CELLS; HUMANS; KINETICS; PHOSPHORYLATION; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PROTEIN KINASES; PYRAZOLES; PYRIMIDINES; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84860779985     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.20208     Document Type: Article

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