LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes

Endocrinology

Volumn 142, Issue 9, 2001, Pages 3980-3986

  Shoba, Lungile N N ^a   Newman, Marsha ^a   Liu, Wenli ^a   Lowe Jr , William L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN C; STAT5 PROTEIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RIBONUCLEASE PROTECTION ASSAY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0034870176     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.142.9.8394     Document Type: Article

References (51)

1. Tissue concentrations of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action
2. Insulin-like growth factors and their binding proteins: Biological actions
3. Insulin-like growth factor I: Physiology, metabolic effects and clinical uses
4. Regulation of IGF-I gene expression. Implications for normal and pathological growth
5. Growth hormone rapidly activates insulin-like growth factor I gene transcription in vivo
6. Differential expression of alternative 5′ untranslated regions in mRNAs encoding rat insulin-like growth factor 1
7. Growth-hormone-receptor and cytokine-receptor-family signaling
8. Molecular mechanism of growth hormone action
9. Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3- kinase activation via JAK2 kinase
10. STATs: Signal transducers and activators of transcription
11. Growth hormone stimulates phosphorylation and activation of elk-1 and expression of c-fos, egr-1, and junB through activation of extracellular signal-regulated kinases 1 and 2
12. Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes
13. Growth hormone regulates ternary complex factors and serum response factor associated with the c-fos serum response element
14. Studies in rat liver perfusion for optimal harvest of hepatocytes
15. Matrigel treatment of primary hepatocytes following DNA transfection enhances responsiveness to extracellular stimuli
16. Regulation of insulin-like growth factor I messenger ribonucleic acid levels by serum in cultured rat fibroblasts
17. Regulation of insulin-like growth factor I production in rat C6 glioma cells: Possible role as an autocrine/paracrine growth factor
18. Regulation of rat growth hormone receptor gene expression
19. The differential regulation by glucagon and growth hormone of insulin-like growth factor (IGF)-I and IGF binding proteins in cultured rat hepatocytes
20. Expression of insulin-like growth factor I in cultured rat hepatocytes: Effects of insulin and growth hormone
21. Growth hormone induction of insulin-like growth factor I messenger RNA in primary cultures of rat liver cells
22. Growth hormone (GH) regulation of cytochrome P-450IIC12, insulin-like growth factor-I (IGF-I), and GH receptor messenger RNA expression in primary rat hepatocytes: A hormonal interplay with insulin, IGF-I, and thyroid hormone
23. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
24. Identification of core sequences involved in metabolism-dependent nuclear protein binding to the rat insulin-like growth factor I gene
25. A CACCC box in the proximal exon 2 promoter of the rat insulin-like growth factor I gene is required for basal promoter activity
26. Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no alterations in deoxyribonucleic acid- protein interactions within the major promoter
27. Characterization of deoxyribonucleic acid-protein interactions at a growth hormone-inducible nuclease hypersensitive site in the rat insulin-like growth factor-I gene
28. 2 in osteoblasts
29. Transcriptional regulation of the rat insulin-like growth factor-I gene involves metabolism-dependent binding of nuclear proteins to a downstream region
30. Essential promoter elements are located within the 5′ untranslated region of human insulin-like growth factor-I exon I
31. Rapid activation of rat insulin-like growth factor-I gene transcription by growth hormone reveals no changes in deoxyribonucleic acid-protein interactions within the second promoter
32. The major promoter of the rat insulin-like growth factor-I gene binds a protein complex that is required for basal expression
33. Rapid changes in gene expression after in vivo growth hormone treatment
34. Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression
35. Phosphatidylinositol 3-OH kinase activity is not required for activation of mitogen-activated protein kinase by cytokines
36. Signaling by distinct classes of phosphoinositide 3-kinases
37. PI-3-kinase inhibitor Wortmannin blocks the insulin-like effects of growth hormone in isolated rat adipocytes
38. Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes
39. Requirement for phosphoinositide 3-OH kinase in growth hormone signalling to the mitogen-activated protein kinase and p70s6k pathways
40. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation
41. Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen- activated protein kinase and STAT91
42. In vivo growth hormone treatment rapidly stimulates the tyrosine phosphorylation and activation of Stat3
43. Growth hormone stimulates interferon regulatory factor-1 gene expression in the liver
44. Growth hormone and colony-stimulating factor 1 share multiple response elements in the c-fos promoter
45. Male-specific transcription initiation of the C4-Slp gene in mouse liver follows activation of STAT5
46. STAT 5 and NF-Y are involved in expression and growth hormone-mediated sexually dimorphic regulation of cytochrome P450 3A10/lithocholic acid 6β-hydroxylase
47. Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene
48. Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b
49. STAT5 signaling in sexually dimorphic gene expression and growth patterns
50. Growth hormone induction of hepatic serine protease inhibitor 2.1 transcription is mediated by a Stat5-related factor binding synergistically to two γ-activated sites
51. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption