Migraine changes the brain: Neuroimaging makes its mark

Current Opinion in Neurology

Volumn 25, Issue 3, 2012, Pages 252-262

  Sprenger, Till ^a   Borsook, David ^b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Functional MRI; Magnetic resonance spectroscopy; Migraine; PET; Voxel based morphometry

Indexed keywords

4 (2' METHOXYPHENYL) 1 [2' (N 2 PYRIDINYL)PARA FLUOROFBENZAMIDO]ETHYL PIPERAZINE; ANTIMIGRAINE AGENT; BIOLOGICAL MARKER; SUMATRIPTAN; TRACER; UNCLASSIFIED DRUG;

AGING; BRAIN CORTEX; BRAIN FUNCTION; BRAIN MATURATION; BRAIN SCINTISCANNING; BRAIN STEM; CEREBELLUM; DISEASE MARKER; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; GRAY MATTER; HUMAN; HYPOTHALAMUS; MIGRAINE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; SEIZURE; THALAMUS; WHITE MATTER;

BRAIN; HUMANS; MIGRAINE DISORDERS; NEUROIMAGING;

EID: 84860738357     PISSN: 13507540     EISSN: 14736551     Source Type: Journal    
DOI: 10.1097/WCO.0b013e3283532ca3     Document Type: Review

References (85)

1. Cutrer FM, O'Donnell A, Sanchez del Rio M. Functional neuroimaging: enhanced understanding of migraine pathophysiology. Neurology 2000; 55 (Suppl 2):S36-S45.
2. Anttila V, Stefansson H, Kallela M, et al. Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1. Nat Genet 2010; 42:869-873.
3. Villeneuve PJ, Szyszkowicz M, Stieb D, Bourque DA. Weather and emergency room visits for migraine headaches in Ottawa, Canada. Headache 2006; 46:64-72.
4. Vijayan N, Gould S, Watson C. Exposure to sun and precipitation of migraine. Headache 1980; 20:42-43.
5. Robbins L. Precipitating factors in migraine: a retrospective review of 494 patients. Headache 1994; 34:214-216.
6. Galiano L, Montiel I, Falip R, et al. Stress as a precipitating factor in migraine. Rev Neurol 1995; 23:830-832.
7. MacGregor EA. Migraine headache in perimenopausal and menopausal women. Curr Pain Headache Rep 2009; 13:399-403.
8. Dalkara T, Zervas NT, Moskowitz MA. From spreading depression to the trigeminovascular system. Neurol Sci 2006; 27 (Suppl 2):S86-S90.
9. Zhang X, Levy D, Kainz V, et al. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol 2011; 69:855-865.
10. Ebersberger A, Schaible HG, Averbeck B, Richter F. Is there a correlation between spreading depression, neurogenic inflammation, and nociception that might cause migraine headache? Ann Neurol 2001; 49:7-13.
11. Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011; 17:439-447.
12. Sprenger T SC, Valet M, Staehle K, Toelle TR, Foerschler, Zimmer C, Goadsby PJ. Abnormal interictal large-scale brain network connectivity in episodic migraine. Headache 2010; 50(suppl 1):71.
13. Weiller C, May A, Limmroth V, et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995; 1:658-660.
14. Welch KM, Nagesh V, Aurora SK, Gelman N. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 2001; 41:629-637.
15. Knight YE, Goadsby PJ. The periaqueductal grey matter modulates trigeminovascular input: a role in migraine? Neuroscience 2001; 106:793-800.
16. Kruit MC, Launer LJ, Overbosch J, et al. Iron accumulation in deep brain nuclei in migraine: a population-based magnetic resonance imaging study. Cephalalgia 2009; 29:351-359.
17. Rocca MA, Ceccarelli A, Falini A, et al. Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke 2006; 37:1765-1770.
18. Cao Y, Aurora SK, Nagesh V, et al. Functional MRI-BOLD of brainstem structures during visually triggered migraine. Neurology 2002; 59:72-78.
19. Dunckley P, Wise RG, Fairhurst M, et al. A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 2005; 25:7333-7341.
20. Demarquay G, Lothe A, Royet JP, et al. Brainstem changes in 5-HT1A receptor availability during migraine attack. Cephalalgia 2011; 31:84-94.
21. Afridi SK, Giffin NJ, Kaube H, et al. A positron emission tomographic study in spontaneous migraine. Arch Neurol 2005; 62:1270-1275.
22. Denuelle M, Fabre N, Payoux P, et al. Hypothalamic activation in spontaneous migraine attacks. Headache 2007; 47:1418-1426.
23. Afridi SK, Matharu MS, Lee L, et al. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 2005; 128 (Pt 4): 932-939.
24. Moulton EA, Burstein R, Tully S, et al. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One 2008; 3:e3799.
25. Stankewitz A, Aderjan D, Eippert F, May A. Trigeminal nociceptive transmission in migraineurs predicts migraine attacks. J Neurosci 2011; 31:1937-1943.
26. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack: clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain 2000; 123 (Pt 8):1703-1709.
27. Burstein R, Jakubowski M, Garcia-Nicas E, et al. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol 2010; 68:81-91.
28. Noseda R, Kainz V, Jakubowski M, et al. A neural mechanism for exacerbation of headache by light. Nat Neurosci 2010; 13:239-245.
29. Maleki N, Becerra L, Upadhyay J, et al. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp 2011; 33:75-88.
30. Moulton EA, Becerra L, Maleki N, et al. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine states. Cereb Cortex 2011; 21:435-448.
31. Eickhoff SB, Laird AR, Grefkes C, et al. Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty. Hum Brain Mapp 2009; 30:2907-2926.
32. Denuelle M, Boulloche N, Payoux P, et al. A PET study of photophobia during spontaneous migraine attacks. Neurology 2011; 76:213-218.
33. Bramanti P, Grugno R, Vitetta A, et al. Ictal and interictal hypoactivation of the occipital cortex in migraine with aura. A neuroimaging and electrophysiological study. Funct Neurol 2005; 20:169-171.
34. Chen WT, Lin YY, Fuh JL, et al. Sustained visual cortex hyperexcitability in migraine with persistent visual aura. Brain 2011; 134 (Pt 8):2387-2395.
35. Lee JH, Durand R, Gradinaru V, et al. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 2010; 465:788-792.
36. Sprenger T, Ruether KV, Boecker H, et al. Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia 2007; 27:1033-1042.
37. Stankewitz A, May A. Increased limbic and brainstem activity during migraine attacks following olfactory stimulation. Neurology 2011; 77:476-482.
38. Maleki N, Becerra L, Nutile L, et al. Migraine attacks the basal ganglia. Mol Pain 2011; 7:71.
39. Borsook D, Upadhyay J, Chudler EH, Becerra L. A key role of the basal ganglia in pain and analgesia: insights gained through human functional imaging. Mol Pain 2010; 6:27.
40. Demarquay G, Royet JP, Mick G, Ryvlin P. Olfactory hypersensitivity in migraineurs: a H(2)(15)O-PET study. Cephalalgia 2008; 28:1069-1080.
41. Nunes JC, Zakon DB, Claudino LS, et al. Hippocampal sclerosis and ipsilateral headache among mesial temporal lobe epilepsy patients. Seizure 2011; 20:480-484.
42. Tessitore A, Russo A, Esposito F, et al. Interictal cortical reorganization in episodic migraine without aura: an event-related fMRI study during parametric trigeminal nociceptive stimulation. Neurol Sci 2011; 32 (Suppl 1):S165-S167.
43. Aderjan D, Stankewitz A, May A. Neuronal mechanisms during repetitive trigemino-nociceptive stimulation in migraine patients. Pain 2010; 151:97-103.
44. Coppola G, Pierelli F, Schoenen J. Habituation and migraine. Neurobiol Learn Mem 2009; 92:249-259.
45. Coppola G, Pierelli F, Schoenen J. Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia 2007; 27:1427-1439.
46. Boulloche N, Denuelle M, Payoux P, et al. Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain. J Neurol Neurosurg Psychiatry 2010; 81:978-984.
47. Eck J, Richter M, Straube T, et al. Affective brain regions are activated during the processing of pain-related words in migraine patients. Pain 2011; 152:1104-1113.
48. May A, Ashburner J, Buchel C, et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999; 5:836-838.
49. Apkarian AV, Sosa Y, Sonty S, et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J Neurosci 2004; 24:10410-10415.
50. May A. New insights into headache: an update on functional and structural imaging findings. Nat Rev Neurol 2009; 5:199-209.
51. Rodriguez-Raecke R, Niemeier A, Ihle K, et al. Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J Neurosci 2009; 29:13746-13750.
52. DaSilva AF, Granziera C, Tuch DS, et al. Interictal alterations of the trigeminal somatosensory pathway and periaqueductal gray matter in migraine. Neuroreport 2007; 18:301-305.
53. Schmitz N, Admiraal-Behloul F, Arkink EB, et al. Attack frequency and disease duration as indicators for brain damage in migraine. Headache 2008; 48:1044-1055.
54. Rocca MA, Ceccarelli A, Falini A, et al. Diffusion tensor magnetic resonance imaging at 3.0 tesla shows subtle cerebral grey matter abnormalities in patients with migraine. J Neurol Neurosurg Psychiatry 2006; 77:686-689.
55. DaSilva AF, Granziera C, Snyder J, Hadjikhani N. Thickening in the somatosensory cortex of patients with migraine. Neurology 2007; 69:1990-1995.
56. Hadjikhani N. Relevance of cortical thickness in migraine sufferers. Expert Rev Neurother 2008; 8:327-329.
57. Valfre W, Rainero I, Bergui M, Pinessi L. Voxel-based morphometry reveals gray matter abnormalities in migraine. Headache 2008; 48:109-117.
58. Sarchielli P, Tarducci R, Presciutti O, et al. Functional 1H-MRS findings in migraine patients with and without aura assessed interictally. Neuroimage 2005; 24:1025-1031.
59. Sandor PS, Dydak U, Schoenen J, et al. MR-spectroscopic imaging during visual stimulation in subgroups of migraine with aura. Cephalalgia 2005; 25:507-518.
60. Schulz UG, Blamire AM, Corkill RG, et al. Association between cortical metabolite levels and clinical manifestations of migrainous aura: an MRspectroscopy study. Brain 2007; 130 (Pt 12):3102-3110.
61. Schulz UG, Blamire AM, Davies P, et al. Normal cortical energy metabolism in migrainous stroke: a 31P-MR spectroscopy study. Stroke 2009; 40:3740-3744.
62. Boska MD, Welch KM, Barker PB, et al. Contrasts in cortical magnesium, phospholipid and energy metabolism between migraine syndromes. Neurology 2002; 58:1227-1233.
63. Prescot A, Becerra L, Pendse G, et al. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain 2009; 5:34.
64. Barrett CF, van den Maagdenberg AM, Frants RR, Ferrari MD. Familial hemiplegic migraine. Adv Genet 2008; 63:57-83.
65. Dichgans M, Herzog J, Freilinger T, et al. 1H-MRS alterations in the cerebellum of patients with familial hemiplegic migraine type 1. Neurology 2005; 64:608-613.
66. Toldo I, Cecchin D, Sartori S, et al. Multimodal neuroimaging in a child with sporadic hemiplegic migraine: a contribution to understanding pathogenesis. Cephalalgia 2011; 31:751-756.
67. van den Heuvel MP, Hulshoff Pol HE. Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 2010; 20:519-534.
68. Rosazza C, Minati L. Resting-state brain networks: literature review and clinical applications. Neurol Sci 2011; 32:773-785.
69. Ferraro S, Grazzi L, Mandelli ML, et al. Pain processing in medication overuse headache: a functional magnetic resonance imaging (fMRI) study. Pain Med 2011; 13:255-262.
70. Linde M, Elam M, Lundblad L, et al. Sumatriptan (5-HT1B/1D-agonist) causes a transient allodynia. Cephalalgia 2004; 24:1057-1066.
71. Kramer HH, Lundblad L, Birklein F, et al. Activation of the cortical pain network by soft tactile stimulation after injection of sumatriptan. Pain 2007; 133:72-78.
72. Bjornsdotter M, Loken L, Olausson H, et al. Somatotopic organization of gentle touch processing in the posterior insular cortex. J Neurosci 2009; 29:9314-9320.
73. Loken LS, Wessberg J, Morrison I, et al. Coding of pleasant touch by unmyelinated afferents in humans. Nat Neurosci 2009; 12:547-548.
74. Upadhyay J, Maleki N, Potter J, et al. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain 2010; 133 (Pt 7):2098-2114.
75. Dusitanond P, Young WB. Neuroleptics and migraine. Cent Nerv Syst Agents Med Chem 2009; 9:63-70.
76. Garcia-Martin E, Martinez C, Serrador M, et al. Dopamine receptor 3 (DRD3) polymorphism and risk for migraine. Eur J Neurol 2010; 17:1220-1223.
77. Charbit AR, Akerman S, Goadsby PJ. Dopamine: what's new in migraine? Curr Opin Neurol 2010; 23:275-281.
78. Rollene NL, Khan Z, Schroeder DR, et al. Migraines and ovarian hyperstimulation syndrome: a dopamine connection. Fertil Steril 2011; 95:417-419.
79. Bigal ME, Lipton RB. Clinical course in migraine: conceptualizing migraine transformation. Neurology 2008; 71:848-855.
80. Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov 2006; 5:411-424.
81. Becerra L, Harter K, Gonzalez RG, Borsook D. Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers. Anesth Analg 2006; 103:208-216.
82. Dang-Vu TT, Schabus M, Desseilles M, et al. Functional neuroimaging insights into the physiology of human sleep. Sleep 2010; 33:1589-1603.
83. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1. The need, reality, challenges, and solutions. Discov Med 2011; 11:197-207.
84. Borsook D, Becerra L. CNS animal fMRI in pain and analgesia. Neurosci Biobehav Rev 2011; 35:1125-1143.
85. Borsook D, Hargreaves R, Becerra L. Can functional magnetic resonance imaging improve success rates in CNS drug discovery? Expert Opin Drug Discov 2011; 6:597-617.