Interictal dysfunction of a brainstem descending modulatory center in migraine patients

PLoS ONE

Volumn 3, Issue 11, 2008, Pages

  Moulton, Eric A ^a,b   Burstein, Rami ^c   Tully, Shannon ^a   Hargreaves, Richard ^d   Becerra, Lino ^a,b   Borsook, David ^a,b  

^a MCLEAN HOSPITAL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BRAIN FUNCTION; BRAIN MAPPING; BRAIN NUCLEUS; BRAIN STEM; CLINICAL ARTICLE; CONTROLLED STUDY; FACILITATION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEAT SENSATION; HUMAN; MALE; MEDULLA OBLONGATA; MIGRAINE; NERVE CELL NETWORK; NERVE CONDUCTION; NERVE EXCITABILITY; NEUROMODULATION; NOCICEPTIVE STIMULATION; SPINAL CORD DORSAL HORN; CASE CONTROL STUDY; HEAT; MIDDLE AGED; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PAIN THRESHOLD; PATHOPHYSIOLOGY;

ADULT; BRAIN MAPPING; BRAIN STEM; CASE-CONTROL STUDIES; FEMALE; HOT TEMPERATURE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MIGRAINE DISORDERS; NEURONS; PAIN; PAIN THRESHOLD;

EID: 57049142731     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003799     Document Type: Article

References (46)

1. Rocca MA, Ceccarelli A, Falini A, Colombo B, Tortorella P, et al. (2006) Brain gray matter changes in migraine patients with T2-visible lesions: a 3-T MRI study. Stroke 37: 1765-1770.
2. Welch KM, Nagesh V, Aurora SK, Gelman N (2001) Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 41: 629-637.
3. Weiller C, May A, Limmroth V, Juptner M, Kaube H, et al. (1995) Brain stem activation in spontaneous human migraine attacks. Nat Med 1: 658-660.
4. Afridi SK, Giffin NJ, Kaube H, Friston KJ, Ward NS, et al. (2005) A positron emission tomographic study in spontaneous migraine. Arch Neurol 62: 1270-1275.
5. Bahra A, Matharu MS, Buchel C, Frackowiak RS, Goadsby PJ (2001) Brainstem activation specific to migraine headache. Lancet 357: 1016-1017.
6. Fields HL, Basbaum AI, Heinricher MM (2006) Central nervous system mechanisms of pain modulation. Wall and Melzack's Textbook of Pain. New Year: Elsevier, Church Livingstone.
7. Ossipov MH, Hong Sun T, Malan P Jr, Lai J, Porreca F (2000) Mediation of spinal nerve injury induced tactile allodynia by descending facilitatory pathways in the dorsolateral funiculus in rats. Neurosci Lett 290: 129-132.
8. Kovelowski CJ, Ossipov MH, Sun H, Lai J, Malan TP, et al. (2000) Supraspinal cholecystokinin may drive tonic descending facilitation mechanisms to maintain neuropathic pain in the rat. Pain 87: 265-273.
9. Zemlan FP, Behbehani MM (1988) Nucleus cuneiformis and pain modulation: anatomy and behavioral pharmacology. Brain Res 453: 89-102.
10. Richter RC, Behbehani MM (1991) Evidence for glutamic acid as a possible neurotransmitter between the mesencephalic nucleus cuneiformis and the medullary nucleus raphe magnus in the lightly anesthetized rat. Brain Res 544: 279-286.
11. Behbehani MM, Zemlan FP (1986) Response of nucleus raphe magnus neurons to electrical stimulation of nucleus cuneiformis: role of acetylcholine. Brain Res 369: 110-118.
12. Haghparast A, Ordikhani-Seyedlar M, Ziaei M (2008) Electrolytic lesion of the nucleus raphe magnus reduced the antinociceptive effects of bilateral morphine microinjected into the nucleus cuneiformis in rats. Neurosci Lett 438: 351-355.
13. Haghparast A, Soltani-Hekmat A, Khani A, Komaki A (2007) Role of glutamatergic receptors located in the nucleus raphe magnus on antinociceptive effect of morphine microinjected into the nucleus cuneiformis of rat. Neurosci Lett 427: 44-49.
14. Dunckley P, Wise RG, Fairhurst M, Hobden P, Aziz Q, et al. (2005) A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 25: 7333-7341.
15. Keltner JR, Furst A, Fan C, Redfern R, Inglis B, et al.(2006) Isolating the modulatory effect of expectation on pain transmission: a functional magnetic resonance imaging study. J Neurosci 26: 4437-4443.
16. Zambreanu L, Wise RG, Brooks JC, Iannetti GD, Tracey I (2005) A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain 114: 397-407.
17. Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, et al. (2007) Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage 35: 1586-1600.
18. DaSilva AF, Becerra L, Makris N, Strassman AM, Gonzalez RG, et al. (2002) Somatotopic activation in the human trigeminal pain pathway. Journal of Neuroscience 22: 8183-8192.
19. Becerra L, Morris S, Bazes S, Gostic R, Sherman S, et al. (2006) Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. The Journal of Neuroscience 26: 10646-10657.
20. Smith SM, Jenkinson M, Woolrich MW, Beckmann CF, Behrens TE, et al. (2004) Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23 Suppl 1: S208-219.
21. Woolrich MW, Ripley BD, Brady M, Smith SM (2001) Temporal autocorrelation in univariate linear modeling of FMRI data. Neuroimage 14: 1370-1386.
22. Moulton EA, Pendse G, Morris S, Aiello-Lammens M, Becerra L, et al. (2008) Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex. Hum Brain Mapp.
23. Basbaum AI, Fields HL (1984) Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci 7: 309-338.
24. Pan ZZ, Fields HL (1996) Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla. Neuroscience 74: 855-862.
25. McMahon SB, Wall PD (1985) Electrophysiological mapping of brainstem projections of spinal cord lamina I cells in the rat. Brain Res 333: 19-26.
26. Wiberg M, Westman J, Blomqvist A (1987) Somatosensory projection to the mesencephalon: an anatomical study in the monkey. J Comp Neurol 264: 92-117.
27. Yezierski RP, Schwartz RN (1984) Receptive field properties of spinomesencephalic tract (SMT) cells. Pain Suppl., 2: S127.
28. Hadjipavlou G, Dunckley P, Behrens TE, Tracey I (2006) Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controls. Pain 123: 169-178.
29. Menetrey D, Chaouch A, Besson JM (1980) Location and properties of dorsal horn neurons at origin of spinoreticular tract in lumbar enlargement of the rat. J Neurophysiol 44: 862-877.
30. Olesen TS, Friberg L, Lassen NA (1987) Ischemia may be the primary cause of the neurologic deficits in classic migraine. Arch Neurol 44: 156-161.
31. Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, et al. (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64: 1020-1026.
32. Rocca MA, Colombo B, Pratesi A, Comi G, Filippi M (2000) A magnetization transfer imaging study of the brain in patients with migraine. Neurology 54: 507-509.
33. Haws CM, Williamson AM, Fields HL (1989) Putative nociceptive modulatory neurons in the dorsolateral pontomesencephalic reticular formation. Brain Res 483: 272-282.
34. Olausson HW, Cole J, Vallbo A, McGlone F, Elam M, et al. (2008) Unmyelinated tactile afferents have opposite effects on insular and somatosensory cortical processing. Neurosci Lett 436: 128-132.
35. Bernard JF, Peschanski M, Besson JM (1989) Afferents and efferents of the rat cuneiformis nucleus: an anatomical study with reference to pain transmission. Brain Res 490: 181-185.
36. Schoenen J (2006) Neurophysiological features of the migrainous brain. Neurol Sci 27 Suppl 2: S77-81.
37. Fairhurst M, Wiech K, Dunckley P, Tracey I (2007) Anticipatory brainstem activity predicts neural processing of pain in humans. Pain 128: 101-110.
38. Tortorella P, Rocca MA, Colombo B, Annovazzi P, Comi G, et al. (2006) Assessment of MRI abnormalities of the brainstem from patients with migraine and multiple sclerosis. J Neurol Sci 244: 137-141.
39. Schummers J, Yu H, Sur M (2008) Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 320: 1638-1643.
40. Zemlan FP, Behbehani MM (1984) Afferent projections to the nucleus cuneiformis in the rat. Neurosci Lett 52: 103-109.
41. Burstein R, Jakubowski M (2005) Unitary hypothesis for multiple triggers of the pain and strain of migraine. J Comp Neurol 493: 9-14.
42. Knight YE, Goadsby PJ (2001) The periaqueductal grey matter modulates trigeminovascular input: a role in migraine? Neuroscience 106: 793-800.
43. Welch KM (2003) Contemporary concepts of migraine pathogenesis. Neurology 61: S2-8.
44. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R (2006) Frequency of headache is related to sensitization: a population study. Pain 123: 19-27.
45. Loder E, Biondi D (2005) General principles of migraine management: the changing role of prevention. Headache 45 Suppl 1: S33-47.
46. Duvernoy HM (1995) The human brain stem and cerebellum. Surface, structure, vascularization and three-dimensional anatomy with MRI. Wien: Springer.