Iron accumulation in deep brain nuclei in migraine: A population-based magnetic resonance imaging study

Cephalalgia

Volumn 29, Issue 3, 2009, Pages 351-359

  Kruit, M C ^a   Launer, L J ^b,c   Overbosch, J ^a   Van Buchem, M A ^a   Ferrari, M D ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Iron accumulation; Magnetic resonance imaging; Migraine; Pain processing

Indexed keywords

ANTIHYPERTENSIVE AGENT; ERGOTAMINE; IRON; TRIPTAN DERIVATIVE;

ADULT; ANTINOCICEPTION; ARTICLE; BIOACCUMULATION; BRAIN NUCLEUS; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GLOBUS PALLIDUS; HUMAN; HYPERTENSION; IRON STORAGE; MAJOR CLINICAL STUDY; MALE; MIGRAINE; MIGRAINE AURA; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN; PATHOPHYSIOLOGY; PERIAQUEDUCTAL GRAY MATTER; POPULATION RESEARCH; PUTAMEN; RED NUCLEUS; TISSUE LEVEL;

AGE FACTORS; BRAIN; BRAIN CHEMISTRY; FEMALE; HUMANS; IRON; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MIGRAINE DISORDERS;

EID: 59149088370     PISSN: 03331024     EISSN: 14682982     Source Type: Journal    
DOI: 10.1111/j.1468-2982.2008.01723.x     Document Type: Article

References (39)

1. Headache Classification Subcommittee of The International Headache Society. The international classification of headache disorders: 2nd edition. Cephalalgia 2004 24 (Suppl. 1 9 160.
2. Launer LJ, Terwindt GM, Ferrari MD. The prevalence and characteristics of migraine in a population-based cohort: the GEM study. Neurology 1999 53 : 537 42.
3. Katsarava Z, Schneeweiss S, Kurth T, Kroener U, Fritsche G, Eikermann A et al. Incidence and predictors for chronicity of headache in patients with episodic migraine. Neurology 2004 62 : 788 90.
4. Scher AI, Stewart WF, Ricci JA, Lipton RB. Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 2003 106 : 81 9.
5. Knight YE, Goadsby PJ. The periaqueductal grey matter modulates trigeminovascular input: a role in migraine? Neuroscience 2001 106 : 793 800.
6. Goadsby PJ. Migraine pathophysiology. Headache 2005 45 (Suppl. 1 S14 24.
7. Welch KM, Nagesh V, Aurora SK, Gelman N. Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 2001 41 : 629 37.
8. Weiller C, May A, Limmroth V, Juptner M, Kaube H, Schayck RV et al. Brain stem activation in spontaneous human migraine attacks. Nat Med 1995 1 : 658 60.
9. Cao Y, Welch KM, Aurora S, Vikingstad EM. Functional MRI-BOLD of visually triggered headache in patients with migraine. Arch Neurol 1999 56 : 548 54.
10. Bahra A, Matharu MS, Buchel C, Frackowiak RS, Goadsby PJ. Brainstem activation specific to migraine headache. Lancet 2001 357 : 1016 17.
11. Afridi SK, Matharu MS, Lee L, Kaube H, Friston KJ, Frackowiak RS, Goadsby PJ. A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain 2005 128 : 932 9.
12. Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ. Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study. Brain 2004 127 : 220 30.
13. Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ. Migraine as a risk factor for subclinical brain lesions. JAMA 2004 291 : 427 34.
14. Boer JM, Feskens EJ, Schouten EG, Havekes LM, Seidell JC, Kromhout D. Lipid profiles reflecting high and low risk for coronary heart disease: contribution of apolipoprotein E polymorphism and lifestyle. Atherosclerosis 1998 136 : 395 402.
15. Schenker C, Meier D, Wichmann W, Boesiger P, Valavanis A. Age distribution and iron dependency of the T2 relaxation time in the globus pallidus and putamen. Neuroradiology 1993 35 : 119 24.
16. Bartzokis G, Mintz J, Sultzer D, Marx P, Herzberg JS, Phelan CK, Marder SR. In vivo MR evaluation of age-related increases in brain iron. Am J Neuroradiol 1994 15 : 1129 38.
17. Rockwell DT, Melhem ER, Bhatia RG. GRASE (gradient- and spin-echo) MR of the brain. Am J Neuroradiol 1997 18 : 1923 8.
18. Thompson KJ, Shoham S, Connor JR. Iron and neurodegenerative disorders. Brain Res Bull 2001 55 : 155 64.
19. Halliwell B. Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 2001 18 : 685 716.
20. Hallgren B, Sourander P. The effect of age on the non-haemin iron in the human brain. J Neurochem 1958 3 : 41 51.
21. Dobson J. Nanoscale biogenic iron oxides and neurodegenerative disease. FEBS Lett 2001 496 : 1 5.
22. Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of brain iron: birth of a biomarker? NMR Biomed 2004 17 : 433 45.
23. Vymazal J, Brooks RA, Patronas N, Hajek M, Bulte JW, Di Chiro G. Magnetic resonance imaging of brain iron in health and disease. J Neurol Sci 1995 134 (Suppl 19 26.
24. Iadarola MJ, Berman KF, Zeffiro TA, Byas-Smith MG, Gracely RH, Max MB, Bennett GJ. Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain 1998 121 : 931 47.
25. Welch KM, Cao Y, Aurora S, Wiggins G, Vikingstad EM. MRI of the occipital cortex, red nucleus, and substantia nigra during visual aura of migraine. Neurology 1998 51 : 1465 9.
26. Lipton RB, Pan J. Is migraine a progressive brain disease? JAMA 2004 291 : 493 4.
27. Lipton RB, Bigal ME. Migraine: epidemiology, impact, and risk factors for progression. Headache 2005 45 (Suppl. 1 S3 13.
28. Knight YE, Bartsch T, Kaube H, Goadsby PJ. P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? J Neurosci 2002 22 : RC213.
29. 2+ channel gene CACNL1A4. Cell 1996 87 : 543 52.
30. Goadsby PJ. Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia 2002 22 : 107 11.
31. Gee JR, Chang J, Dublin AB, Vijayan N. The association of brainstem lesions with migraine-like headache: an imaging study of multiple sclerosis. Headache 2005 45 : 670 7.
32. Tortorella P, Rocca MA, Colombo B, Annovazzi P, Comi G, Filippi M. Assessment of MRI. Abnormalities of the brainstem from patients with migraine and multiple sclerosis. J Neurol Sci 2006 244 : 137 41.
33. Vymazal J, Hajek M, Patronas N, Giedd JN, Bulte JW, Baumgarner C et al. The quantitative relation between T1-weighted and T2-weighted MRI of normal gray matter and iron concentration. J Magn Reson Imaging 1995 5 : 554 60.
34. Aoki S, Okada Y, Nishimura K, Barkovich AJ, Kjos BO, Brasch RC, Norman D. Normal deposition of brain iron in childhood and adolescence: MR imaging at 1.5 T. Radiology 1989 172 : 381 5.
35. Pujol J, Junque C, Vendrell P, Grau JM, Marti-Vilalta JL, Olive C, Gili J. Biological significance of iron-related magnetic resonance imaging changes in the brain. Arch Neurol 1992 49 : 711 17.
36. Swartz RH, Kern RZ. Migraine is associated with magnetic resonance imaging white matter abnormalities: a meta-analysis. Arch Neurol 2004 61 : 1366 8.
37. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Brain stem and cerebellar hyperintense lesions in migraine. Stroke 2006 37 : 1109 12.
38. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 2005 330 : 63.
39. Kruit MC, Launer LJ, Ferrari MD, van Buchem MA. Infarcts in the posterior circulation territory in migraine: the population-based MRI CAMERA study. Brain 2005 128 : 2068 77.