Global and local fMRI signals driven by neurons defined optogenetically by type and wiring

Nature

Volumn 465, Issue 7299, 2010, Pages 788-792

  Lee, Jin Hyung ^a,b   Durand, Remy ^b   Gradinaru, Viviana ^b   Zhang, Feng ^b   Goshen, Inbal ^b   Kim, Dae Shik ^c,d   Fenno, Lief E ^b   Ramakrishnan, Charu ^b   Deisseroth, Karl ^b,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Stanford University   (United States)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY PATTERN; ADVANCED TECHNOLOGY; BLOOD; BRAIN; CORRELATION; GENETIC ANALYSIS; KINETICS; MAMMAL; PHENOTYPE; VISUALIZATION;

ARTICLE; BRAIN NERVE CELL; CELL POPULATION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC IDENTIFICATION; GENETIC REGULATION; NEOCORTEX; NERVE CELL STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THALAMUS;

ACTION POTENTIALS; ALGAE, GREEN; ANESTHESIA; ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; LUMINESCENT MEASUREMENTS; LUMINESCENT PROTEINS; MAGNETIC RESONANCE IMAGING; MOTOR CORTEX; NEURAL PATHWAYS; NEURONS; OXYGEN; PHOTIC STIMULATION; RATS; RHODOPSIN; THALAMUS;

MAMMALIA;

EID: 77953423831     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09108     Document Type: Article

References (30)

1. Ogawa, S. et al. Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc. Natl Acad. Sci. USA 89, 5951-5955 (1992).
2. Logothetis, N. K., Pauls, J., Augath, M., Trinath, T. & Oeltermann, A. Neurophysiological investigation of the basis of the fMRI signal. Nature 412, 150-157 (2001).
3. Cohen, J. D. & Blum, K. I. Reward and decision. Neuron 36, 193-198 (2002).
4. Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nature Neurosci. 8, 1263-1268 (2005).
5. Zhang, F., Wang, L. P., Boyden, E. S. & Deisseroth, K. Channelrhodopsin-2 and optical control of excitable cells. Nature Methods 3, 785-792 (2006).
6. Deisseroth, K. et al. Next-generation optical technologies for illuminating genetically targeted brain circuits. J. Neurosci. 26, 10380-10386 (2006).
7. Zhang, F. et al. Multimodal fast optical interrogation of neural circuitry. Nature 446, 633-639 (2007).
8. Zhang, F., Aravanis, A. M., Adamantidis, A., de Lecea, L. & Deisseroth, K. Circuit-breakers: optical technologies for probing neural signals and systems. Nature Rev. Neurosci. 8, 577-581 (2007).
9. Aravanis, A. M. et al. An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J. Neural Eng. 4, S143-S156 (2007).
10. Sohal, V. S., Zhang, F., Yizhar, O. & Deisseroth, K. Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature 459, 698-702 (2009).
11. Gradinaru, V., Mogri, M., Thompson, K. R., Henderson, J. M. & Deisseroth, K. Optical deconstruction of parkinsonian neural circuitry. Science 324, 354-359 (2009).
12. Zhang, F. et al. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nature Protocols 5, 439-456 (2010).
13. Gradinaru, V. et al. Molecular and cellular approaches for diversifying and extending optogenetics. Cell 141, 154-165 (2010)
14. Friston, K. J. Functional and effective connectivity in neuroimaging: a synthesis. Hum. Brain Mapp. 2, 56-78 (1994).
15. Ug?urbil, K. et al. Functional mapping in the human brain using high magnetic fields. Phil. Trans. R. Soc. Lond. B 354, 1195-1213 (1999).
16. Logothetis, N. K. What we can do and what we cannot do with fMRI. Nature 453, 869-878 (2008).
17. Douglas, R. J. & Martin, K. A. A functional microcircuit for cat visual cortex. J. Physiol. (Lond.) 440, 735-769 (1991).
18. Sirotin, Y. B. & Das, A. Anticipatory haemodynamic signals in sensory cortex not predicted by local neuronal activity. Nature 457, 475-479 (2009).
19. Cauli, B. et al. Cortical GABA Interneurons in neurovascular coupling: relays for subcortical vasoactive pathways. J. Neurosci. 24, 8940-8949 (2004).
20. Masamoto, K., Kim, T., Fukuda, M., Wang, P. & Kim, S. G. Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb. Cortex 17, 942-950 (2007).
21. Lee, J. H. et al. Full-brain coverage and high-resolution imaging capabilities of passband b-SSFP fMRI at 3T. Magn. Reson. Med. 59, 1099-1110 (2008).
22. Lee, J. H., Hargreaves, B. A., Hu, B. S. & Nishimura, D. G. Fast 3D imaging using variable-density spiral trajectories with applications to limb perfusion. Magn. Reson. Med. 50, 1276-1285 (2003).
23. Glover, G. H. & Lee, A. T. Motion artifacts in fMRI: comparison of 2DFT with PR and spiral scan methods. Magn. Reson. Med. 33, 624-635 (1995).
24. Buxton, R. B., Wong, E. C. & Frank, L. R. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn. Reson. Med. 39, 855-864 (1998).
25. Boynton, G. M., Engel, S. A., Glover, G. H. & Heeger, D. J. Linear systems analysis of functional magnetic resonance imaging in human V1. J. Neurosci. 16, 4207-4221 (1996).
26. Donahue, M. J. et al. Theoretical and experimental investigation of the VASO contrast mechanism. Magn. Reson. Med. 56, 1261-1273 (2006).
27. Lauritzen, M. Reading vascular changes in brain imaging: is dendritic calcium the key? Nature Rev. Neurosci. 6, 77-85 (2005).
28. Nir, Y., Dinstein, I., Malach, R. & Heeger, D. J. BOLD and spiking activity. Nature Neurosci. 11, 523-524, author reply 524 (2008).
29. Alloway, K. D., Olson, M. L. & Smith, J. B. Contralateral corticothalamic projections from MI whisker cortex: potential route for modulating hemispheric interactions. J. Comp. Neurol. 510, 100-116 (2008).
30. Kuramoto, E. et al. Two types of thalamocortical projections from the motor thalamic nuclei of the rat: a single neuron-tracing study using viral vectors. Cereb. Cortex 19, 2065-2077 (2009).