Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: Randomised clinical trial

Lancet

Volumn 363, Issue 9402, 2004, Pages 18-22

  Hien, Tran Tinh ^a   Dolecek, Christiane ^b,c   Mai, Pham Phuong ^a   Dung, Nguyen Thi ^a   Truong, Nguyen Thanh ^a   Thai, Le Hong ^a   An, Dong Thi Hoai ^b   Thanh, Tran Tan ^b   Stepniewska, Kasia ^c   White, Nicholas J ^b,c   Farrar, Jeremy ^b,c  

^a UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^b The Hospital for Tropical Diseases   (Viet Nam)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; DIHYDROARTEMISININ; MEFLOQUINE; PIPERAQUINE; TRIMETHOPRIM;

ADOLESCENT; ADULT; AGED; ARTICLE; ATAXIA; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; FOLLOW UP; GENOTYPE; HEALTH CENTER; HEALTH STATUS; HOSPITAL; HUMAN; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; MULTICENTER STUDY; NEUROLOGIC DISEASE; NONHUMAN; OPEN STUDY; PATIENT REFERRAL; PILOT STUDY; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REINFECTION; SIDE EFFECT; SLURRED SPEECH; STANDARDIZATION; VIET NAM; VOMITING;

EID: 9144262694     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(03)15163-X     Document Type: Article

References (15)

1. Nosten F., Brasseur P. Combination therapy for Malaria. Drugs. 62:2002;1315-1329.
2. White N.J., Nosten F., Looareesuwan S., et al. Averting a malaria disaster. Lancet. 353:1999;1965-1967.
3. WHO. Antimalarial drug combination therapy: report of a WHO Technical Consultation. Geneva: World Health Organization, April 2001; WHO/CDS/RBM/2001.35.
4. van Vugt M.V., Wilairatana P., Gemperli B., et al. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria. Am J Trop Med Hyg. 60:1999;936-942.
5. Brockman A., Paul REL., Anderson T.J.C., et al. Application of genetic markers to the identification of recrudescent Plasmodium falciparum infections on the northwestern border of Thailand. Am J Trop Med Hyg. 60:1999;14-21.
6. Newcombe, Robert G. Interval estimation for the difference between independent proportions: comparison of eleven methods. Stat Med 1998; 17: 873-90.
7. Brockman A., Price R.N., van Vugt M., et al. Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Artesunale Thailand during five years of extensive Artesunate-mefloquine use. Trans R Soc Trop Med Hyg. 94:2000;537-544.
8. Huong N.M., Hewitt S., Davis T.M., et al. Resistance of Plasmodium falciparum to antimalarial drugs in a highly endemic area of southern Viet Nam: a study in vivo and in vitro. Trans R Soc Trop Med Hyg. 95:2001;325-329.
9. Nosten F., Hien T.T., White N.J. Use of artemisinin derivatives for the control of malaria. Med Trop (Mars). 58:(suppl 3):1998;45-49.
10. Hien T.T. An overview of the clinical use of artemisinin and its derivatives in the treatment of falciparum malaria in Viet Nam. Trans R Soc Trop Med Hyg. 88:1994;S7-S8.
11. Raynes K. Bisquinoline antimalarials: their role in malaria chemotherapy. Int J Parasitol. 29:1999;367-379.
12. Guo X.B., Fu L.C. Comparative study of artemisinin suppositories and piperaquine phosphate in the treatment of falciparum malaria. Chung Hsi I Chieh Ho Tsa Chih. 9:1989;475-477.
13. Lin C., Feng-yi Q., Yan-chang Z. Field observations of the antimalarial piperaquine. Chinese Med J. 95:1982;281-286.
14. Changxiong L., Xiu L., Zaisong H., et al. In vivo sensitivity of Plasmodium falciparum to piperaquine phosphate assayed in Linshui and Baisha Counties, Hainan Province. Chin J Parasitol Parasitic Dis. 7:1989;163-165.
15. Denis M.B., Davis T.M., Hewitt S., et al. Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria. Clin Infect Dis. 35:2002;1469-1476.