An open randomized clinical trial of Artekin® vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria

Southeast Asian Journal of Tropical Medicine and Public Health

Volumn 36, Issue 5, 2005, Pages 1085-1091

  Tangpukdee, N ^a   Krudsood, S ^a   Thanachartwet, W ^a   Chalermrut, K ^b   Pengruksa, C ^b   Srivilairit, S ^b   Silachamroon, U ^a   Wilairatana, P ^a   Phongtananant, S ^a   Kano, S ^c   Looareesuwan, S ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 30344465041     PISSN: 01251562     EISSN: 26975718     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Brockman A, Price RN, van Vugt M, et al. Plasmodium falciparum antimalarial drug susceptibility on the northwestern border of Thailand during five years of extensive artesunate-mefloquine use. Trans R Soc Trop Med Hyg 2000; 94: 537-44.
2. Chen L, Qu FY, Zhou YC. Field observations of the antimalarial piperaquine. Chin Med J 1982; 95: 281-6.
3. Davis TM, Hung TY, Sim IK, et al. Piperaquine: a resurgent antimalarial drug. Drugs 2005; 65: 75-87.
4. Denis MB, Devis TM, Hewitt S, et al. Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria. Clin Infect Dis 2002; 35: 1469-76.
5. Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Annual report, 2004: 80.
6. Hien TT, Dolecek C, Mai PP, et al. Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomized clinical trial. Lancet 2004; 363: 18-22.
7. Hien TT, Tam DT, Cuc NT, Arnold K. Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute falciparum malaria. Trans R Soc Trop Med Hyg 1991; 85: 201-11.
8. Karunajeewa H, Lim C, Hung TY, et al. Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin,) in Cambodian children and adults with malaria. Br J Clin Pharmacol 2003; 57: 93-99.
9. Li GQ, Guo XB, Fu LC, et al. Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Trans R Soc Trop Med Hyg 1994; 88: S5-6.
10. Looareesuwan S, Kyle DE, Viravan C, et al. Treatment of patients with recrudescent falciparum malaria with a sequential combination of artesunate and mefloquine. Am J Trop Med Hyg 1992; 47: 794-9.
11. Looareesuwan S, Vanijanonta S, Viravan C, et al. Randomised trial of mefloquine alone, and artesunate followed by mefloquine for the treatment of acute uncomplicated falciparum malaria. Ann Trop Med Parasitol 1994; 88: 131-6.
12. Looareesuwan S, Viravan C, Vanijanonta S, et al. Comparative clinical trial of artesunate followed by mefloquine in the treatment of acute uncomplicated falciparum malaria: two and three-day regimens. Am J Trop Med Hyg 1996; 54: 210-3.
13. Looareesuwan S, Wilairatana P, Chokejindachai W, et al. A randomized, double-blind, comparative trial of a new oral combination of artemether and benflumetol (CGP 56697) with mefloquine in the treatment of acute Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 1999; 60: 238-43.
14. Looareesuwan S, Wilairatana P, Vanijanonta S, et al. Monotherapy with artesunate for uncomplicated falciparum malaria: a comparison of 5-day and 7-day regimens. Acta Trop 1997; 67: 197-205.
15. Nosten F, Brasseur P. Combination therapy for malaria. Drug 2002; 62: 1315-29.
16. Nosten F, Kuile F, Chongsuphajaisiddhi T, et al. Mefloquine- resistant falciparum malaria on the Thai-Burmese border. Lancet 1991 ; i : 1140-3.
17. Price RN, Nosten F, Luxemburger C, et al. Artesunate-mefloquine treatment of 1967 patients with multidrug resistant falciparum malaria. Trans R Soc Trop Med Hyg 1997; 91: 574-7.
18. th ed. USA: Allyn & Bacon, 2001: 41-5.
19. Tropical Medicine Institute, Guangzhou University of Traditional Chinese Medicine, Chinese. Documentation of Artekin for new drug registration. 2003.
20. Warhurst DC. Drug resistance in Plasmodium falciparum malaria. Infection 1999; 27: S55-8.
21. Wilairatana P, Krudsood S, Chalermrut K, et al. An open randomized clinical trial of Artecom vs Artesunate-Mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand. Southeast Asian J Trop Med Public Health 2002; 33: 519-24.
22. World Health Organization. Advances in malaria chemotherapy. WHO Tech Rep Ser 1973; 529: 30-5.
23. World Health Organization. Antimalarial drug combination therapy: report of a WHO Technical Consultation. Geneva: WHO, April 2001: 35.
24. World Health Organization. Guidelines for treatment of severe malaria in hospitals. 2004. [Accessed 2005 May]. Availableat: at: URL: http://mosquito.WHO. int/docs/smSEARO.pdf
25. nd ed. Geneva: WHO, 2000.