Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat

Journal of Pharmaceutical Sciences

Volumn 97, Issue 8, 2008, Pages 3400-3410

  Tarning, J ^a   Lindegardh, N ^b,c   Sandberg, S ^a   Day, N J P ^b,c   White, N J ^b,c   Ashton, M ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b MAHIDOL UNIVERSITY   (Thailand)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Biliary excretion; Bioanalysis; Clearance; Distribution; Mass spectrometry; Metabolism; Pharmacokinetics; Preclinical pharmacokinetics; Renal excretion

Indexed keywords

ANTIMALARIAL AGENT; CARBOXYLIC ACID; PIPERAQUINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG FORMULATION; DRUG METABOLISM; DRUG STRUCTURE; EMULSION; FECES ANALYSIS; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; URINALYSIS; VENOUS BLOOD;

EID: 52449086887     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21226     Document Type: Article

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