Enhanced antitumor efficacy, biodistribution and penetration of docetaxel-loaded biodegradable nanoparticles

International Journal of Pharmaceutics

Volumn 430, Issue 1-2, 2012, Pages 350-358

  Liu, Qin ^a   Li, Rutian ^a   Zhu, Zhenshu ^b   Qian, Xiaoping ^a   Guan, Wenxian ^a   Yu, Lixia ^a   Yang, Mi ^a   Jiang, Xiqun ^c   Liu, Baorui ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Antitumor; Biodistribution; Docetaxel; Nanoparticles; Tumor penetration

Indexed keywords

BIOPOLYMER; COPOLYMER; DOCETAXEL; MACROGOL; NANOPARTICLE; POLYCAPROLACTONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER MODEL; CELL NUCLEUS; COMPUTER ASSISTED TOMOGRAPHY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG PENETRATION; DRUG RELEASE; DRUG RETENTION; DRUG TRANSPORT; DRUG TUMOR LEVEL; ENDOCYTOSIS; IMMUNOHISTOCHEMISTRY; LIVER CANCER; LIVER PARENCHYMA; MALE; MOLECULAR IMAGING; MOUSE; NANOENCAPSULATION; NANOFABRICATION; NANOPHARMACEUTICS; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; POSITRON EMISSION TOMOGRAPHY; PRECIPITATION; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; ENDOCYTOSIS; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAVENOUS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; POLYESTERS; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; SPECTROSCOPY, NEAR-INFRARED; TAXOIDS; TECHNOLOGY, PHARMACEUTICAL; TISSUE DISTRIBUTION; TUMOR BURDEN;

EID: 84860720425     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.008     Document Type: Article

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