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Volumn 34, Issue 2, 2010, Pages 131-149

Current problems with systemic treatment of advanced hepatocellular cancer
[No Author Info available]

Author keywords

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Indexed keywords

7 HYDROXYSTAUROSPORINE; BEVACIZUMAB; CAPECITABINE; CD135 ANTIGEN; CETUXIMAB; CIXUTUMUMAB; DOXORUBICIN; ERLOTINIB; EVEROLIMUS; FLAVOPIRIDOL; GEFITINIB; GEMCITABINE; INDISULAM; LAPATINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OXALIPLATIN; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; RAF PROTEIN; RAPAMYCIN; SORAFENIB; STEM CELL FACTOR; SUNITINIB; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; ANTINEOPLASTIC AGENT; BENZENESULFONIC ACID DERIVATIVE; PROTEIN TYROSINE KINASE; PYRIDINE DERIVATIVE;

EID: 77955083432     PISSN: 01470272     EISSN: 15356345     Source Type: Journal    
DOI: 10.1016/j.currproblcancer.2010.03.001     Document Type: Review
Times cited : (4)

References (101)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007;132(7):2557-76.
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 63049133092 scopus 로고    scopus 로고
    • Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    • Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol 2009;27(9):1485-91.
    • (2009) J Clin Oncol , vol.27 , Issue.9 , pp. 1485-1491
    • Altekruse, S.F.1    McGlynn, K.A.2    Reichman, M.E.3
  • 3
    • 85031192960 scopus 로고    scopus 로고
    • http://www.cancer.org/docroot/stt/stt_0.asp.
  • 4
    • 0034941503 scopus 로고    scopus 로고
    • Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years
    • Poon RT, Fan ST, Lo CM, et al. Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg 2001;234(1):63-70.
    • (2001) Ann Surg , vol.234 , Issue.1 , pp. 63-70
    • Poon, R.T.1    Fan, S.T.2    Lo, C.M.3
  • 5
    • 17344368270 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma as an entity with a high rate of surgical cure
    • Takayama T, Makuuchi M, Hirohashi S, et al. Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatoly 1998;28(5):1241-6.
    • (1998) Hepatoly , vol.28 , Issue.5 , pp. 1241-1246
    • Takayama, T.1    Makuuchi, M.2    Hirohashi, S.3
  • 6
    • 0032532086 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantation
    • More E, Kaspa RT, Sheiner P, et al. Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantation. Ann Intern Med 1998;129(8):643-53.
    • (1998) Ann Intern Med , vol.129 , Issue.8 , pp. 643-653
    • More, E.1    Kaspa, R.T.2    Sheiner, P.3
  • 7
    • 0001605891 scopus 로고    scopus 로고
    • Hepatic tumors and cysts
    • Feldman M, Sleisenger M, Scharschmidt B, Klein S, eds. (ed 6). Philadelphia, PA: WB Saunders
    • Kew M. Hepatic tumors and cysts. In: Feldman M, Sleisenger M, Scharschmidt B, Klein S, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathology/ Diagnosis/Management (ed 6, vol 1). Philadelphia, PA: WB Saunders, 1998:1364-87.
    • (1998) Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathology/ Diagnosis/Management , vol.1 , pp. 1364-1387
    • Kew, M.1
  • 9
    • 34548720158 scopus 로고    scopus 로고
    • Randomized phase III trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC)
    • Llovet J, Ricci S, Mazzaferro V, et al. Randomized phase III trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC). Proc Am Soc Clin Oncol 2007;25(Suppl):18S.
    • (2007) Proc Am Soc Clin Oncol , vol.25 , Issue.SUPPL.
    • Llovet, J.1    Ricci, S.2    Mazzaferro, V.3
  • 10
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6(9):674-87.
    • (2006) Nat Rev Cancer , vol.6 , Issue.9 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 11
    • 67650224486 scopus 로고    scopus 로고
    • Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma
    • Feo F, Frau M, Tomasi ML, et al. Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma. Exp Biol Med Maywood 2009;234(7):726-36.
    • (2009) Exp Biol Med Maywood , vol.234 , Issue.7 , pp. 726-736
    • Feo, F.1    Frau, M.2    Tomasi, M.L.3
  • 12
    • 0037382526 scopus 로고    scopus 로고
    • Hunting for tumor suppressor genes in liver cancer
    • Thorgeirsson SS. Hunting for tumor suppressor genes in liver cancer. J Hepatol 2003;37(4):739-41.
    • (2003) J Hepatol , vol.37 , Issue.4 , pp. 739-741
    • Thorgeirsson, S.S.1
  • 13
    • 1642544603 scopus 로고    scopus 로고
    • Focus on hepatocellular carcinoma
    • Bruix J, Boix L, Sala M, et al. Focus on hepatocellular carcinoma. Cancer Cell 2004;5(3):215-9.
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 215-219
    • Bruix, J.1    Boix, L.2    Sala, M.3
  • 14
    • 33847069207 scopus 로고    scopus 로고
    • Genomics and signaling pathways in hepatocellular carcinoma
    • Villanueva A, Newell P, Chiang DY, et al. Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis 2007;27(1):55-76.
    • (2007) Semin Liver Dis , vol.27 , Issue.1 , pp. 55-76
    • Villanueva, A.1    Newell, P.2    Chiang, D.Y.3
  • 15
    • 70349253352 scopus 로고    scopus 로고
    • Hepatitis B virus induced hepatocellular carcinoma
    • Chemin I, Zoulim F. Hepatitis B virus induced hepatocellular carcinoma. Cancer Lett 2009;286(1):52-9.
    • (2009) Cancer Lett , vol.286 , Issue.1 , pp. 52-59
    • Chemin, I.1    Zoulim, F.2
  • 16
    • 57349182990 scopus 로고    scopus 로고
    • Pathogenesis of HCV-associated HCC: dual-pass carcinogenesis through activation of oxidative stress and intracellular signaling
    • Koike K. Pathogenesis of HCV-associated HCC: dual-pass carcinogenesis through activation of oxidative stress and intracellular signaling. Hepatol Res 2007;37 (Suppl 2):S115-20.
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 2
    • Koike, K.1
  • 17
    • 0034283772 scopus 로고    scopus 로고
    • Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma
    • Chung YH, Kim JA, Song BC, et al. Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma. Cancer 2000;89(5):977-82.
    • (2000) Cancer , vol.89 , Issue.5 , pp. 977-982
    • Chung, Y.H.1    Kim, J.A.2    Song, B.C.3
  • 18
    • 0141828970 scopus 로고    scopus 로고
    • Mechanisms of human hepatocarcinogenesis
    • Coleman WB. Mechanisms of human hepatocarcinogenesis. Curr Mol Med 2003; 3(6):573-88.
    • (2003) Curr Mol Med , vol.3 , Issue.6 , pp. 573-588
    • Coleman, W.B.1
  • 19
    • 1442335098 scopus 로고    scopus 로고
    • Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma
    • Wiesenauer CA, Yip-Schneider MT, Wang Y, et al. Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg 2004;198(3):410-21.
    • (2004) J Am Coll Surg , vol.198 , Issue.3 , pp. 410-421
    • Wiesenauer, C.A.1    Yip-Schneider, M.T.2    Wang, Y.3
  • 20
    • 23944435911 scopus 로고    scopus 로고
    • Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma
    • Osada S, Kanematsu M, Imai H, et al. Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma. J Am Coll Surg 2005;201(3):405-11.
    • (2005) J Am Coll Surg , vol.201 , Issue.3 , pp. 405-411
    • Osada, S.1    Kanematsu, M.2    Imai, H.3
  • 21
    • 19944432263 scopus 로고    scopus 로고
    • Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis
    • Schiffer E, Housset C, Cacheux W, et al. Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Hepatoly 2005;41(2):307-14.
    • (2005) Hepatoly , vol.41 , Issue.2 , pp. 307-314
    • Schiffer, E.1    Housset, C.2    Cacheux, W.3
  • 22
    • 4143074965 scopus 로고    scopus 로고
    • An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis
    • Alexia C, Fallot G, Lasfer M, et al. An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 2004;68(6):1003-15.
    • (2004) Biochem Pharmacol , vol.68 , Issue.6 , pp. 1003-1015
    • Alexia, C.1    Fallot, G.2    Lasfer, M.3
  • 23
    • 18044387648 scopus 로고    scopus 로고
    • Raf kinase as a target for anticancer therapeutics
    • Sridhar SS, Hedley D, Siu LL. Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther 2005;4(4):677-85.
    • (2005) Mol Cancer Ther , vol.4 , Issue.4 , pp. 677-685
    • Sridhar, S.S.1    Hedley, D.2    Siu, L.L.3
  • 24
    • 0032773895 scopus 로고    scopus 로고
    • Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma
    • Harada K, Shiota G, Kawasaki H. Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. Liver 1999;19(4):318-25.
    • (1999) Liver , vol.19 , Issue.4 , pp. 318-325
    • Harada, K.1    Shiota, G.2    Kawasaki, H.3
  • 25
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study
    • Okano J, Shiota G, Kawasaki H. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver 1999;19(2):151-9.
    • (1999) Liver , vol.19 , Issue.2 , pp. 151-159
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 26
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in human hepatocellular carcinoma
    • Yamaguchi R, Yano H, Iemura A, et al. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatoly 1998;28(1):68-77.
    • (1998) Hepatoly , vol.28 , Issue.1 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3
  • 27
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/STAT pathways in human HCC
    • Calvisi DF, Ladu S, Gorden A, et al. Ubiquitous activation of Ras and Jak/STAT pathways in human HCC. Gastroenterology 2006;130(4):1117-28.
    • (2006) Gastroenterology , vol.130 , Issue.4 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 28
    • 70349443677 scopus 로고    scopus 로고
    • A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas
    • Bekaii-Saab T, Markowitz J, Prescott N, et al. A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin Cancer Res 2009;15(18):5895-901.
    • (2009) Clin Cancer Res , vol.15 , Issue.18 , pp. 5895-5901
    • Bekaii-Saab, T.1    Markowitz, J.2    Prescott, N.3
  • 29
    • 33745532794 scopus 로고    scopus 로고
    • Genetics of hepatocellular tumors
    • Laurent-Puig P, Zucman-Rossi J. Genetics of hepatocellular tumors. Oncogene 2006;25(27):3778-86.
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3778-3786
    • Laurent-Puig, P.1    Zucman-Rossi, J.2
  • 30
    • 0037624602 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma
    • Tannapfel A, Sommerer F, Benicke M, et al. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut 2003;52(5):706-12.
    • (2003) Gut , vol.52 , Issue.5 , pp. 706-712
    • Tannapfel, A.1    Sommerer, F.2    Benicke, M.3
  • 31
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ, Wohlschlaeger J, Lang H, et al. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 2008;48(1):83-90.
    • (2008) J Hepatol , vol.48 , Issue.1 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3
  • 32
    • 0035799529 scopus 로고    scopus 로고
    • Sustained activation of the Raf/MEK/erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein
    • Giambartolomei S, Covone F, Levrero M, et al. Sustained activation of the Raf/MEK/erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene 2001;20(20):2606-10.
    • (2001) Oncogene , vol.20 , Issue.20 , pp. 2606-2610
    • Giambartolomei, S.1    Covone, F.2    Levrero, M.3
  • 33
    • 4644259265 scopus 로고    scopus 로고
    • Kinase inhibition with bay 43-9006 in renal cell carcinoma
    • Ahmad T, Eisen T. Kinase inhibition with bay 43-9006 in renal cell carcinoma. Clin Cancer Res 2004;10(18 Pt 2):6388S-92S.
    • (2004) Clin Cancer Res , vol.10 , Issue.18 PART 2
    • Ahmad, T.1    Eisen, T.2
  • 34
    • 4944249117 scopus 로고    scopus 로고
    • Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the ref/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the ref/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64(19):7099-109.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 35
    • 53049086329 scopus 로고    scopus 로고
    • Focal gains of VEGFA and molecular classification of hepatocellular carcinoma
    • Chiang DY, Villanueva A, Hoshida Y, et al. Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res 2008;68(16):6779-88.
    • (2008) Cancer Res , vol.68 , Issue.16 , pp. 6779-6788
    • Chiang, D.Y.1    Villanueva, A.2    Hoshida, Y.3
  • 36
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009;10(1):25-34.
    • (2009) Lancet Oncol , vol.10 , Issue.1 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 37
    • 44649200810 scopus 로고    scopus 로고
    • Final results of phase II, randomized, double-blind study of sorafenib plus doxorubicin and placebo plus doxorubicin in patients with advanced hepatocellular carcinoma
    • Abstract
    • Abou-Alfa GK, Knox J, et al. Final results of phase II, randomized, double-blind study of sorafenib plus doxorubicin and placebo plus doxorubicin in patients with advanced hepatocellular carcinoma. Eur J Cancer 2007;5(4):Abstract 3500.
    • (2007) Eur J Cancer , vol.5 , Issue.4 , pp. 3500
    • Abou-Alfa, G.K.1    Knox, J.2
  • 38
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip PA, Mahoney MR, Allmer C, et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005;23(27):6657-63.
    • (2005) J Clin Oncol , vol.23 , Issue.27 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 39
    • 33750929534 scopus 로고    scopus 로고
    • Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperatvie Oncology Group's study E1203
    • O'Dwyer PJ, Giantonio BJ, Levy DE, et al. Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperatvie Oncology Group's study E1203. J Clin Oncol 2006;24:4143.
    • (2006) J Clin Oncol , vol.24 , pp. 4143
    • O'Dwyer, P.J.1    Giantonio, B.J.2    Levy, D.E.3
  • 40
    • 34547102484 scopus 로고    scopus 로고
    • Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Stuart K, Blaszkowsky LS, et al. Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer 2007;110(3):581-9.
    • (2007) Cancer , vol.110 , Issue.3 , pp. 581-589
    • Zhu, A.X.1    Stuart, K.2    Blaszkowsky, L.S.3
  • 41
    • 36348947270 scopus 로고    scopus 로고
    • A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results
    • Abstract
    • Gruenwald V, Wilkens L, Gebel M, et al. A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J Clin Oncol 2007;25: Abstract 4598.
    • (2007) J Clin Oncol , vol.25 , pp. 4598
    • Gruenwald, V.1    Wilkens, L.2    Gebel, M.3
  • 42
    • 72449204288 scopus 로고    scopus 로고
    • A phase II study of AZD6244 in advanced or metastatic hepatocellular carcinoma
    • Abstract
    • O'Neil BH, Williams-Goff LW, Kauh J, et al. A phase II study of AZD6244 in advanced or metastatic hepatocellular carcinoma. J Clin Oncol 2009;27(Suppl): Abstract e15574.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • O'Neil, B.H.1    Williams-Goff, L.W.2    Kauh, J.3
  • 43
    • 36348998474 scopus 로고    scopus 로고
    • Gemcitabine, oxaliplatin (GEMOX) and cetuximab for treatment of hepatocellular carcinoma (HCC): results of the phase II study ERGO
    • Abstract
    • Louafi S, Hebbar M, Rosmorduc O, et al. Gemcitabine, oxaliplatin (GEMOX) and cetuximab for treatment of hepatocellular carcinoma (HCC): results of the phase II study ERGO. J Clin Oncol 2007;25(18S):Abstract 4594.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 4594
    • Louafi, S.1    Hebbar, M.2    Rosmorduc, O.3
  • 44
    • 58149223575 scopus 로고    scopus 로고
    • Phase II study of oxliplatin, capecitabine, and cetuximab in advanced hepatocellular carcinoma
    • Abstract
    • O'Neil BH, Bernard SA, Goldberg RM, et al. Phase II study of oxliplatin, capecitabine, and cetuximab in advanced hepatocellular carcinoma. J Clin Oncol 2008;26(suppl):Abstract 4604.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL. , pp. 4604
    • O'Neil, B.H.1    Bernard, S.A.2    Goldberg, R.M.3
  • 45
    • 34548150925 scopus 로고    scopus 로고
    • Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma
    • Thomas MB, Chadha R, Glover K, et al. Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer 2007;110(5):1059-67.
    • (2007) Cancer , vol.110 , Issue.5 , pp. 1059-1067
    • Thomas, M.B.1    Chadha, R.2    Glover, K.3
  • 47
    • 0037130449 scopus 로고    scopus 로고
    • Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas
    • Taniguchi K, Roberts LR, Aderca IN, et al. Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene 2002;21(31):4863-71.
    • (2002) Oncogene , vol.21 , Issue.31 , pp. 4863-4871
    • Taniguchi, K.1    Roberts, L.R.2    Aderca, I.N.3
  • 48
    • 0035805117 scopus 로고    scopus 로고
    • The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin
    • Huber AH, Weis WI. The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell 2001;105(3): 391-402.
    • (2001) Cell , vol.105 , Issue.3 , pp. 391-402
    • Huber, A.H.1    Weis, W.I.2
  • 49
    • 2542546650 scopus 로고    scopus 로고
    • Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells
    • Cha MY, Kim CM, Park YM, et al. Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatoly 2004;39(6):1683-93.
    • (2004) Hepatoly , vol.39 , Issue.6 , pp. 1683-1693
    • Cha, M.Y.1    Kim, C.M.2    Park, Y.M.3
  • 50
    • 22544433759 scopus 로고    scopus 로고
    • Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin
    • Ding Q, Xia W, Liu JC, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 2005;19(2):159-70.
    • (2005) Mol Cell , vol.19 , Issue.2 , pp. 159-170
    • Ding, Q.1    Xia, W.2    Liu, J.C.3
  • 51
    • 17844372967 scopus 로고    scopus 로고
    • Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression
    • Fukutomi T, Zhou Y, Kawai S, et al. Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatoly 2005;41(5):1096-105.
    • (2005) Hepatoly , vol.41 , Issue.5 , pp. 1096-1105
    • Fukutomi, T.1    Zhou, Y.2    Kawai, S.3
  • 52
    • 14544270262 scopus 로고    scopus 로고
    • Mutations of beta-catenin and axing I genes are a late event in human hepatocellular carcinogenesis
    • Park JY, Park WS, Nam SW, et al. Mutations of beta-catenin and axing I genes are a late event in human hepatocellular carcinogenesis. Liver Int 2005;25(1):70-6.
    • (2005) Liver Int , vol.25 , Issue.1 , pp. 70-76
    • Park, J.Y.1    Park, W.S.2    Nam, S.W.3
  • 53
    • 35648947815 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma
    • Nomoto S, Kinoshita T, Kato K, et al. Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. Br J Cancer 2007;97(9):1260-5.
    • (2007) Br J Cancer , vol.97 , Issue.9 , pp. 1260-1265
    • Nomoto, S.1    Kinoshita, T.2    Kato, K.3
  • 54
    • 33749344520 scopus 로고    scopus 로고
    • Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
    • Lee TK, Poon RT, Yuen AP, et al. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res 2006;12(18):5369-76.
    • (2006) Clin Cancer Res , vol.12 , Issue.18 , pp. 5369-5376
    • Lee, T.K.1    Poon, R.T.2    Yuen, A.P.3
  • 55
    • 0032484502 scopus 로고    scopus 로고
    • Allelotype analysis of hepatocellular carcinoma
    • Piao Z, Park C, Park JH, et al. Allelotype analysis of hepatocellular carcinoma. Int J Cancer 1998;75(1):29-33.
    • (1998) Int J Cancer , vol.75 , Issue.1 , pp. 29-33
    • Piao, Z.1    Park, C.2    Park, J.H.3
  • 56
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001;120(7):1763-73.
    • (2001) Gastroenterology , vol.120 , Issue.7 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3
  • 57
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • Villanueva A, Chiang DY, Newell P, et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 2008;135:1972-83.
    • (2008) Gastroenterology , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3
  • 58
    • 54949110530 scopus 로고    scopus 로고
    • Activation of Akt-mTOR-p70s6k pathway in angiogenesis in hepatocellular carcinoma
    • Li W, Tan D, Zhang Z, et al. Activation of Akt-mTOR-p70s6k pathway in angiogenesis in hepatocellular carcinoma. Oncol Rep 2008;20(4):713-9.
    • (2008) Oncol Rep , vol.20 , Issue.4 , pp. 713-719
    • Li, W.1    Tan, D.2    Zhang, Z.3
  • 59
    • 0034790016 scopus 로고    scopus 로고
    • MTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, et al. MTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001;8(3):249-58.
    • (2001) Endocr Relat Cancer , vol.8 , Issue.3 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3
  • 60
    • 0034079163 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas
    • Fujiwara Y, Hoon DS, Yamada T, et al. PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. Jpn J Cancer Res 2000;91(3):287-92.
    • (2000) Jpn J Cancer Res , vol.91 , Issue.3 , pp. 287-292
    • Fujiwara, Y.1    Hoon, D.S.2    Yamada, T.3
  • 61
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman DS, de Reyniès A, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. J Hepatol 2007;45(1):42-52.
    • (2007) J Hepatol , vol.45 , Issue.1 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reyniès, A.3
  • 62
    • 73349090909 scopus 로고    scopus 로고
    • Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma
    • Hui IC, Tung EK, Sze KM, et al. Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma. Liver Int 2009;30(1):65-75.
    • (2009) Liver Int , vol.30 , Issue.1 , pp. 65-75
    • Hui, I.C.1    Tung, E.K.2    Sze, K.M.3
  • 63
    • 69949129964 scopus 로고    scopus 로고
    • Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo
    • Newell P, Toffanin S, Villanueva A, et al. Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol 2009;51(4):725-33.
    • (2009) J Hepatol , vol.51 , Issue.4 , pp. 725-733
    • Newell, P.1    Toffanin, S.2    Villanueva, A.3
  • 64
    • 77952085946 scopus 로고    scopus 로고
    • Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients(pts) with advanced hepatocellular carcinoma (HCC)
    • Abstract
    • Chen L, Shiah HS, Chen CY, et al. Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients(pts) with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2009;27(Suppl):Abstract 4587.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4587
    • Chen, L.1    Shiah, H.S.2    Chen, C.Y.3
  • 65
  • 66
    • 59149101341 scopus 로고    scopus 로고
    • Daily dose of perifosine less toxic than weekly and active in patients with hepatocellular carcinoma (HCC)
    • Campos LT, Stephenson J, Swan F, et al. Daily dose of perifosine less toxic than weekly and active in patients with hepatocellular carcinoma (HCC). J Clin Oncol 2007;25(18S):15072.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 15072
    • Campos, L.T.1    Stephenson, J.2    Swan, F.3
  • 67
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006;25(27):3787-800.
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 68
    • 67651107338 scopus 로고    scopus 로고
    • Pathogenesis of hepatocellular carcinoma and molecular therapies
    • Mínguez B, Tovar V, Chiang D, et al. Pathogenesis of hepatocellular carcinoma and molecular therapies. Curr Opin Gastroenterol 2009;25(3):186-94.
    • (2009) Curr Opin Gastroenterol , vol.25 , Issue.3 , pp. 186-194
    • Mínguez, B.1    Tovar, V.2    Chiang, D.3
  • 69
    • 0035072094 scopus 로고    scopus 로고
    • Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma
    • Kishimoto Y, Morisawa T, Kitano M, et al. Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma. Hepatol Res 2001;20(1):68-83.
    • (2001) Hepatol Res , vol.20 , Issue.1 , pp. 68-83
    • Kishimoto, Y.1    Morisawa, T.2    Kitano, M.3
  • 70
    • 62749203737 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine
    • Hewish M, Chau I, Cunningham D. Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drugs Discov 2009;4(1):54-72.
    • (2009) Recent Pat Anticancer Drugs Discov , vol.4 , Issue.1 , pp. 54-72
    • Hewish, M.1    Chau, I.2    Cunningham, D.3
  • 71
    • 34848903049 scopus 로고    scopus 로고
    • IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor
    • Rowinsky EK, Youssoufian H, Tonra JR, et al. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 2007;13(18 Pt 2):5549s-55s.
    • (2007) Clin Cancer Res , vol.13 , Issue.18 PART 2
    • Rowinsky, E.K.1    Youssoufian, H.2    Tonra, J.R.3
  • 72
    • 0028566475 scopus 로고
    • Growth factor-regulated G1 cyclins
    • discussion 55-7
    • Sherr CJ. Growth factor-regulated G1 cyclins. Stem Cells 1994;12(Suppl 1):47-55, discussion 55-7.
    • (1994) Stem Cells , vol.12 , Issue.SUPPL. 1 , pp. 47-55
    • Sherr, C.J.1
  • 73
    • 0034183775 scopus 로고    scopus 로고
    • Cell cycle control as a basis for cancer drug development (review)
    • McDonald ER 3rd, El-Deiry WS. Cell cycle control as a basis for cancer drug development (review). Int J Oncol 2000;16(5):871-86.
    • (2000) Int J Oncol , vol.16 , Issue.5 , pp. 871-886
    • McDonald III, E.R.1    El-Deiry, W.S.2
  • 74
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew M, Wands J, et al. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350(6317):429-31.
    • (1991) Nature , vol.350 , Issue.6317 , pp. 429-431
    • Bressac, B.1    Kew, M.2    Wands, J.3
  • 75
    • 0027207612 scopus 로고
    • p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines
    • Hsu IC, Tokiwa T, Bennett W, et al. p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis 1993;14(5):987-92.
    • (1993) Carcinogenesis , vol.14 , Issue.5 , pp. 987-992
    • Hsu, I.C.1    Tokiwa, T.2    Bennett, W.3
  • 76
    • 0027157304 scopus 로고
    • Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma
    • Feitelson MA, Zhu M, Duan LX, et al. Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 1993;8(5):1109-17.
    • (1993) Oncogene , vol.8 , Issue.5 , pp. 1109-1117
    • Feitelson, M.A.1    Zhu, M.2    Duan, L.X.3
  • 77
    • 0028084735 scopus 로고
    • Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China
    • Fujimoto Y, Hampton LL, Wirth PJ, et al. Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res 1994;54(1):281-5.
    • (1994) Cancer Res , vol.54 , Issue.1 , pp. 281-285
    • Fujimoto, Y.1    Hampton, L.L.2    Wirth, P.J.3
  • 78
    • 0031045978 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinoma
    • Boige V, Laurent-Puig P. [Genetic alterations associated with hepatocellular carcinoma]. Gastroenterol Clin Biol 1997;21(1):34-44.
    • (1997) Gastroenterol Clin Biol , vol.21 , Issue.1 , pp. 34-44
    • Boige, V.1    Laurent-Puig, P.2
  • 79
    • 0030849123 scopus 로고    scopus 로고
    • Comprehensive allelotyping of human hepatocellular carcinoma
    • Nagai H, Pineau P, Tiollais P, et al. Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene 1997;14(24):2927-33.
    • (1997) Oncogene , vol.14 , Issue.24 , pp. 2927-2933
    • Nagai, H.1    Pineau, P.2    Tiollais, P.3
  • 81
    • 0035886492 scopus 로고    scopus 로고
    • Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis
    • Takeo S, Arai H, Kusano N, et al. Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis. Cancer Genet Cytogenet 2001;130(2):127-32.
    • (2001) Cancer Genet Cytogenet , vol.130 , Issue.2 , pp. 127-132
    • Takeo, S.1    Arai, H.2    Kusano, N.3
  • 82
    • 33750917456 scopus 로고    scopus 로고
    • Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein
    • Schwartz J, Schwartz M, Lehrer D, et al. Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein. J Clin Oncol 2006;24(Suppl):4144.
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. , pp. 4144
    • Schwartz, J.1    Schwartz, M.2    Lehrer, D.3
  • 83
    • 38049092474 scopus 로고    scopus 로고
    • Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring
    • Abstract
    • Malka D, Dromain C, Farace F, et al. Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring. J Clin Oncol 2007;25(18S):Abstract 4570.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 4570
    • Malka, D.1    Dromain, C.2    Farace, F.3
  • 84
    • 84984578313 scopus 로고    scopus 로고
    • Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma
    • Hsu CH, Yang TS, Hsu C, et al. Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer 2010;102:981-6.
    • (2010) Br J Cancer , vol.102 , pp. 981-986
    • Hsu, C.H.1    Yang, T.S.2    Hsu, C.3
  • 85
    • 36549089272 scopus 로고    scopus 로고
    • Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): a phase II study
    • Abstract
    • Sun W, Haller DG, Mykulowycz K, et al. Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): a phase II study. J Clin Oncol 2007;25(18S):Abstract 4574.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 4574
    • Sun, W.1    Haller, D.G.2    Mykulowycz, K.3
  • 86
    • 78650874372 scopus 로고    scopus 로고
    • Sun11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, et al. Sun11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003;2(5):471-8.
    • (2003) Mol Cancer Ther , vol.2 , Issue.5 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3
  • 87
    • 37149017305 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with advanced hepatocellular carcinoma
    • Abstract
    • Zhu AX, Sahani DV, di Tomaso E, et al. A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol 2007;25(18S):Abstract 4637.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S , pp. 4637
    • Zhu, A.X.1    Sahani, D.V.2    di Tomaso, E.3
  • 88
    • 34548322506 scopus 로고    scopus 로고
    • Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC)
    • Faivre S, Raymond E, Douillard J, et al. Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol 2007;25:149s.
    • (2007) J Clin Oncol , vol.25
    • Faivre, S.1    Raymond, E.2    Douillard, J.3
  • 89
    • 58049201181 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate in adult patients with metastatic or surgically unresectable hepatocellular carcinoma (HCC)
    • Abstract 267. Orlando, FL: American Society of Oncology, 25-27 January 2008
    • Hoda D, Catherine C, Strosberg J, et al. Phase II study of sunitinib malate in adult patients with metastatic or surgically unresectable hepatocellular carcinoma (HCC). In 2008 Gastrointestinal Cancer Symposium Abstract 267. Orlando, FL: American Society of Oncology, 25-27 January 2008, p. 202.
    • (2008) Gastrointestinal Cancer Symposium , pp. 202
    • Hoda, D.1    Catherine, C.2    Strosberg, J.3
  • 90
    • 74549122898 scopus 로고    scopus 로고
    • Continuous sunitinib treatment in patients with unresectable hepatocellular carcinoma (HCC): A multicenter phase II trail (SAKK77/06 and SASL 23)
    • Abstract
    • Koeberle D, Montemurro M, Samaras P, et al. Continuous sunitinib treatment in patients with unresectable hepatocellular carcinoma (HCC): A multicenter phase II trail (SAKK77/06 and SASL 23). J Clin Oncol 2009;27(Suppl):Abstract 4591.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4591
    • Koeberle, D.1    Montemurro, M.2    Samaras, P.3
  • 91
    • 33644684217 scopus 로고    scopus 로고
    • Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
    • Strumberg D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today 2005;41(12):773-84.
    • (2005) Drugs Today , vol.41 , Issue.12 , pp. 773-784
    • Strumberg, D.1
  • 92
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008;359(4):378-90.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 93
    • 77955821208 scopus 로고    scopus 로고
    • A phase II study of sorafenib in combination with tegafur/uracil (UFT) for Asian patients with advanced hepatocellular carcinoma (HCC)
    • Abstract
    • Shen Y, Shao Y, Hsu C, et al. A phase II study of sorafenib in combination with tegafur/uracil (UFT) for Asian patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2009;27(Suppl):Abstract 4589.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4589
    • Shen, Y.1    Shao, Y.2    Hsu, C.3
  • 94
    • 77955796298 scopus 로고    scopus 로고
    • A phase II (PhII) trial of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (c.i.) in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary data
    • Abstract
    • Petrini I, Lencioni M, Ricasoli M, et al. A phase II (PhII) trial of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (c.i.) in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary data. J Clin Oncol 2009;27(Suppl):Abstract 4592.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4592
    • Petrini, I.1    Lencioni, M.2    Ricasoli, M.3
  • 95
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008;26 (18):2992-8.
    • (2008) J Clin Oncol , vol.26 , Issue.18 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3
  • 96
    • 38049092474 scopus 로고    scopus 로고
    • Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring
    • Abstract
    • Malka D, Dromian C, Farace F, et al. Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring. J Clin Oncol 2007;25(suppl):Abstract 4570.
    • (2007) J Clin Oncol , vol.25 , Issue.SUPPL. , pp. 4570
    • Malka, D.1    Dromian, C.2    Farace, F.3
  • 97
    • 33646351795 scopus 로고    scopus 로고
    • Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma
    • Zhu AX, Blaszkowsky LS, Ryan DP, et al. Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol 2006;24(12):1898-903.
    • (2006) J Clin Oncol , vol.24 , Issue.12 , pp. 1898-1903
    • Zhu, A.X.1    Blaszkowsky, L.S.2    Ryan, D.P.3
  • 98
    • 60849124241 scopus 로고    scopus 로고
    • Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma
    • Thomas MB, Morris JS, Chadha R, et al. Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol 2009;27(6):843-50.
    • (2009) J Clin Oncol , vol.27 , Issue.6 , pp. 843-850
    • Thomas, M.B.1    Morris, J.S.2    Chadha, R.3
  • 99
    • 68149164263 scopus 로고    scopus 로고
    • A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer
    • Ramanathan RK, Belani CP, Singh DA, et al. A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother Pharmacol 2009;64(4):777-83.
    • (2009) Cancer Chemother Pharmacol , vol.64 , Issue.4 , pp. 777-783
    • Ramanathan, R.K.1    Belani, C.P.2    Singh, D.A.3
  • 100
    • 74549223962 scopus 로고    scopus 로고
    • An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatcellular carcinoma (HCC)
    • Abstract
    • Raoul JL, Finn RS, Kang YK, et al. An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatcellular carcinoma (HCC). J Clin Oncol 2009;27(Suppl):Abstract 4577.
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 4577
    • Raoul, J.L.1    Finn, R.S.2    Kang, Y.K.3
  • 101
    • 67650857880 scopus 로고    scopus 로고
    • Phase II, open lable study of brivanib alaninate in patients with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy
    • Abstract 200. Orlando, FL: American Society of Oncology, 25-27, January 2009
    • Finn RS, Kang Y, Park J, et al. Phase II, open lable study of brivanib alaninate in patients with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy. In 2009 Gastroinestinal Cancers Symposium Abstract 200. Orlando, FL: American Society of Oncology, 25-27, January 2009, p. 202.
    • (2009) Gastroinestinal Cancers Symposium , pp. 202
    • Finn, R.S.1    Kang, Y.2    Park, J.3


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