메뉴 건너뛰기




Volumn 24, Issue 12, 2003, Pages 1977-1984

Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIMETHYLHYDRAZINE; GLYCOPROTEIN P; OROTIC ACID; PROTEIN INHIBITOR; VALSPODAR;

EID: 10744231610     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/bgg159     Document Type: Article
Times cited : (19)

References (48)
  • 1
    • 0026687242 scopus 로고
    • P-glycoprotein expression during tumor progression in the rat liver
    • Bradley,G., Sharma,R., Rajalakshmi,S. and Ling,V. (1992) P-glycoprotein expression during tumor progression in the rat liver. Cancer Res., 52, 5154-5161.
    • (1992) Cancer Res. , vol.52 , pp. 5154-5161
    • Bradley, G.1    Sharma, R.2    Rajalakshmi, S.3    Ling, V.4
  • 3
    • 0023179571 scopus 로고
    • Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver
    • Thorgeirsson,S.S., Huber,B.E., Sorrell,S., Fojo,A., Pastan,I. and Gottesman,M.M. (1987) Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver. Science, 236, 1120-1122.
    • (1987) Science , vol.236 , pp. 1120-1122
    • Thorgeirsson, S.S.1    Huber, B.E.2    Sorrell, S.3    Fojo, A.4    Pastan, I.5    Gottesman, M.M.6
  • 4
    • 0013659750 scopus 로고
    • Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas
    • Fairchild,C.R., Ivy,S.P., Rushmore.T., Lee,G., Koo,P., Goldsmith,M.E., Myers,C.E., Farber,E. and Cowan,K.H. (1987) Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc. Natl Acad. Sci. USA, 84, 7701-7705.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7701-7705
    • Fairchild, C.R.1    Ivy, S.P.2    Rushmore, T.3    Lee, G.4    Koo, P.5    Goldsmith, M.E.6    Myers, C.E.7    Farber, E.8    Cowan, K.H.9
  • 5
    • 0026905756 scopus 로고
    • Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice
    • Kuo,M.T., Zhao,J.Y., Teeter,L.D., Ikeguchi,M. and Chisari,F.V. (1992) Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell Growth Differ., 3, 531-540.
    • (1992) Cell Growth Differ. , vol.3 , pp. 531-540
    • Kuo, M.T.1    Zhao, J.Y.2    Teeter, L.D.3    Ikeguchi, M.4    Chisari, F.V.5
  • 6
    • 0028047406 scopus 로고
    • Constitutive expression of functional P-glycoprotein in rat hepatoma cells
    • Fardel,O., Loyer,P., Lecureur,V., Glaise,D. and Guillouzo,A. (1994) Constitutive expression of functional P-glycoprotein in rat hepatoma cells. Eur. J. Biochem., 219, 521-528.
    • (1994) Eur. J. Biochem. , vol.219 , pp. 521-528
    • Fardel, O.1    Loyer, P.2    Lecureur, V.3    Glaise, D.4    Guillouzo, A.5
  • 7
    • 0025166025 scopus 로고
    • Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas
    • Teeter,L.D., Becker,F.F., Chisari,F.V., Li,D.J. and Kuo,M.T. (1990) Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol. Cell. Biol., 10, 5728-5735.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 5728-5735
    • Teeter, L.D.1    Becker, F.F.2    Chisari, F.V.3    Li, D.J.4    Kuo, M.T.5
  • 8
    • 0024204774 scopus 로고
    • Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals
    • Burt,R.K., Garfield,S., Johnson,K. and Thorgeirsson,S.S. (1988) Transformation of rat liver epithelial cells with v-H-ras or v-raf causes expression of MDR-1, glutathione-S-transferase-P and increased resistance to cytotoxic chemicals. Carcinogenesis, 9, 2329-2332.
    • (1988) Carcinogenesis , vol.9 , pp. 2329-2332
    • Burt, R.K.1    Garfield, S.2    Johnson, K.3    Thorgeirsson, S.S.4
  • 9
    • 0030003252 scopus 로고    scopus 로고
    • MDR1 gene expression in solid tumours
    • Goldstein,L.J. (1996) MDR1 gene expression in solid tumours. Eur. J. Cancer, 32A, 1039-1050.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1039-1050
    • Goldstein, L.J.1
  • 10
    • 0029760088 scopus 로고    scopus 로고
    • Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers
    • Kuo,M.T., Bao,J.J., Curley,S.A., Ikeguchi,M., Johnston,D.A. and Ishikawa,T. (1996) Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res., 56, 3642-3644.
    • (1996) Cancer Res. , vol.56 , pp. 3642-3644
    • Kuo, M.T.1    Bao, J.J.2    Curley, S.A.3    Ikeguchi, M.4    Johnston, D.A.5    Ishikawa, T.6
  • 11
    • 0024538797 scopus 로고
    • Prediction of doxorubicin resistance in vitro in myeloma, lymphoma and breast cancer by P-glycoprotein staining
    • Salmon,S.E., Grogan,T.M., Miller,T., Scheper,R. and Dalton,W.S. (1989) Prediction of doxorubicin resistance in vitro in myeloma, lymphoma and breast cancer by P-glycoprotein staining. J. Natl Cancer Inst., 81, 696-701.
    • (1989) J. Natl. Cancer Inst. , vol.81 , pp. 696-701
    • Salmon, S.E.1    Grogan, T.M.2    Miller, T.3    Scheper, R.4    Dalton, W.S.5
  • 13
    • 0027241335 scopus 로고
    • P-glycoprotein expression predicts response to chemotherapy in previously untreated advanced breast cancer
    • Gasparini,G., Bevilacqua,P., Pozza,F., Meli,S. and Weidner,N. (1993) P-glycoprotein expression predicts response to chemotherapy in previously untreated advanced breast cancer. Breast, 2, 27-32.
    • (1993) Breast , vol.2 , pp. 27-32
    • Gasparini, G.1    Bevilacqua, P.2    Pozza, F.3    Meli, S.4    Weidner, N.5
  • 14
    • 0023889448 scopus 로고
    • Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
    • Sugawara,I., Kataoka,I., Morishita,Y., Hamada,H., Tsuruo,T., Itoyama,S. and Mori,S. (1988) Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16. Cancer Res., 48, 1926-1929.
    • (1988) Cancer Res. , vol.48 , pp. 1926-1929
    • Sugawara, I.1    Kataoka, I.2    Morishita, Y.3    Hamada, H.4    Tsuruo, T.5    Itoyama, S.6    Mori, S.7
  • 15
    • 0027377964 scopus 로고
    • Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
    • Teeter,L.D., Estes,M., Chan,J.Y., Atassi,H., Sell,S., Becker,F.F. and Kuo,M.T. (1993) Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol. Carcinogen., 8, 67-73.
    • (1993) Mol. Carcinogen. , vol.8 , pp. 67-73
    • Teeter, L.D.1    Estes, M.2    Chan, J.Y.3    Atassi, H.4    Sell, S.5    Becker, F.F.6    Kuo, M.T.7
  • 16
    • 0028069259 scopus 로고
    • Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma
    • Itsubo,M., Ishikawa,T., Toda,G. and Tanaka,M. (1994) Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma. Cancer, 73, 298-303.
    • (1994) Cancer , vol.73 , pp. 298-303
    • Itsubo, M.1    Ishikawa, T.2    Toda, G.3    Tanaka, M.4
  • 17
    • 0018374369 scopus 로고
    • Acute intoxication with verapamil
    • Candell,J., Valle,V., Soler,M. and Rius,J. (1979) Acute intoxication with verapamil. Chest, 75, 200-201.
    • (1979) Chest , vol.75 , pp. 200-201
    • Candell, J.1    Valle, V.2    Soler, M.3    Rius, J.4
  • 18
    • 0026353317 scopus 로고
    • Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin
    • [corrected]
    • Twentyman,P.R. and Bleehen,N.M. (1991) Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]. Eur. J. Cancer, 27, 1639-1642.
    • (1991) Eur. J. Cancer , vol.27 , pp. 1639-1642
    • Twentyman, P.R.1    Bleehen, N.M.2
  • 19
    • 0026014503 scopus 로고
    • In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833
    • Boesch,D., Gaveriaux,C., Jachez,B., Pourtier-Manzanedo,A., Bollinger,P. and Loor,F. (1991) In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833. Cancer Res., 51, 4226-4233.
    • (1991) Cancer Res. , vol.51 , pp. 4226-4233
    • Boesch, D.1    Gaveriaux, C.2    Jachez, B.3    Pourtier-Manzanedo, A.4    Bollinger, P.5    Loor, F.6
  • 20
    • 0036361559 scopus 로고    scopus 로고
    • OC144-093, a novel P glycoprotein inhibitor for the enhancement of anti-epileptic therapy
    • Newman,M.J., Dixon,R. and Toyonaga,B. (2002) OC144-093, a novel P glycoprotein inhibitor for the enhancement of anti-epileptic therapy. Novartis Found. Symp., 243, 213-235.
    • (2002) Novartis Found. Symp. , vol.243 , pp. 213-235
    • Newman, M.J.1    Dixon, R.2    Toyonaga, B.3
  • 22
    • 0027524642 scopus 로고
    • In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative
    • Hyafil,F., Vergely,C., Du Vignaud,P. and Grand-Perret,T. (1993) In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative. Cancer Res., 53, 4595-4602.
    • (1993) Cancer Res. , vol.53 , pp. 4595-4602
    • Hyafil, F.1    Vergely, C.2    Du Vignaud, P.3    Grand-Perret, T.4
  • 23
    • 0029809499 scopus 로고    scopus 로고
    • Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979
    • Dantzig,A.H., Shepard,R.L., Cao,J., Law,K.L., Ehlhardt,W.J., Baughman,T.M., Bumol,T.F. and Starling,J.J. (1996) Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res., 56, 4171-4179.
    • (1996) Cancer Res. , vol.56 , pp. 4171-4179
    • Dantzig, A.H.1    Shepard, R.L.2    Cao, J.3    Law, K.L.4    Ehlhardt, W.J.5    Baughman, T.M.6    Bumol, T.F.7    Starling, J.J.8
  • 24
    • 0031950027 scopus 로고    scopus 로고
    • Cytotoxic effect of the cyclosporin PSC 833 in multidrug-resistant leukaemia cells with increased expression of P-glycoprotein
    • Lehne,G. and Rugstad,H.E. (1998) Cytotoxic effect of the cyclosporin PSC 833 in multidrug-resistant leukaemia cells with increased expression of P-glycoprotein. Br. J. Cancer, 78, 593-600.
    • (1998) Br. J. Cancer , vol.78 , pp. 593-600
    • Lehne, G.1    Rugstad, H.E.2
  • 25
    • 0033557521 scopus 로고    scopus 로고
    • SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells
    • Cabot,M.C., Giuliano,A.E., Han,T.Y. and Liu,Y.Y. (1999) SDZ PSC 833, the cyclosporine A analogue and multidrug resistance modulator, activates ceramide synthesis and increases vinblastine sensitivity in drug-sensitive and drug-resistant cancer cells. Cancer Res., 59, 880-885.
    • (1999) Cancer Res. , vol.59 , pp. 880-885
    • Cabot, M.C.1    Giuliano, A.E.2    Han, T.Y.3    Liu, Y.Y.4
  • 26
    • 0033565728 scopus 로고    scopus 로고
    • Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells
    • Lucci,A., Han,T.Y., Liu,Y.Y., Giuliano,A.E. and Cabot,M.C. (1999) Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells. Cancer, 86, 300-311.
    • (1999) Cancer , vol.86 , pp. 300-311
    • Lucci, A.1    Han, T.Y.2    Liu, Y.Y.3    Giuliano, A.E.4    Cabot, M.C.5
  • 27
    • 0031964966 scopus 로고    scopus 로고
    • Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833
    • Bezombes,C., Maestre,N., Laurent,G., Levade,T., Bettaieb,A. and Jaffrezou,J.P. (1998) Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. FASEB J., 12, 101-109.
    • (1998) FASEB J. , vol.12 , pp. 101-109
    • Bezombes, C.1    Maestre, N.2    Laurent, G.3    Levade, T.4    Bettaieb, A.5    Jaffrezou, J.P.6
  • 28
    • 0030964625 scopus 로고    scopus 로고
    • Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts
    • Robinson,L.J., Roberts,W.K., Ling,T.T., Lamming,D., Sternberg,S.S. and Roepe,P.D. (1997) Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts. Biochemistry, 36, 11169-11178.
    • (1997) Biochemistry , vol.36 , pp. 11169-11178
    • Robinson, L.J.1    Roberts, W.K.2    Ling, T.T.3    Lamming, D.4    Sternberg, S.S.5    Roepe, P.D.6
  • 29
    • 0032950954 scopus 로고    scopus 로고
    • P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death
    • Johnstone,R.W., Cretney,E. and Smyth,M.J. (1999) P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood, 93, 1075-1085.
    • (1999) Blood , vol.93 , pp. 1075-1085
    • Johnstone, R.W.1    Cretney, E.2    Smyth, M.J.3
  • 31
    • 0031417121 scopus 로고    scopus 로고
    • SDZ PSC 833: A novel modulator of MDR
    • Covelli,A. (1997) [SDZ PSC 833: a novel modulator of MDR]. Tumori, 83, S21-S24.
    • (1997) Tumori , vol.83
    • Covelli, A.1
  • 32
    • 0027382010 scopus 로고
    • Studies on liver tumor promotion in the rat by orotic acid: Dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis
    • Laconi,E., Denda,A., Rao,P.M., Rajalakshmi,S., Pani,P. and Sarma,D.S.R., (1993) Studies on liver tumor promotion in the rat by orotic acid: dose and minimum exposure time required for dietary orotic acid to promote hepatocarcinogenesis. Carcinogenesis, 14, 1771-1775.
    • (1993) Carcinogenesis , vol.14 , pp. 1771-1775
    • Laconi, E.1    Denda, A.2    Rao, P.M.3    Rajalakshmi, S.4    Pani, P.5    Sarma, D.S.R.6
  • 33
    • 0017656338 scopus 로고
    • Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver
    • Solt,D.B., Hay,J.B. and Farber,E. (1977) Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver. Cancer Res., 37, 1686-1691.
    • (1977) Cancer Res. , vol.37 , pp. 1686-1691
    • Solt, D.B.1    Hay, J.B.2    Farber, E.3
  • 34
    • 0023713427 scopus 로고
    • Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma
    • Feuer,G. (1988) Hepatic metabolism and carcinogenesis. Its role in hepatoma and adenocarcinoma. Ann. N.Y. Acad. Sci., 534, 541-551.
    • (1988) Ann. N.Y. Acad. Sci. , vol.534 , pp. 541-551
    • Feuer, G.1
  • 35
    • 0023357912 scopus 로고
    • Enzyme alterations during chemical hepatocarcinogenesis
    • Sato,K., Satoh,K. and Hatayama,I. (1987) [Enzyme alterations during chemical hepatocarcinogenesis]. Gan To Kagaku Ryoho, 14, 1980-1988.
    • (1987) Gan to Kagaku Ryoho , vol.14 , pp. 1980-1988
    • Sato, K.1    Satoh, K.2    Hatayama, I.3
  • 36
    • 0022831014 scopus 로고
    • Liver tumour promotion by chemicals: Models and mechanisms
    • Sarma,D.S., Rao,P.M. and Rajalakshmi,S. (1986) Liver tumour promotion by chemicals: models and mechanisms. Cancer Surv., 5, 781-798.
    • (1986) Cancer Surv. , vol.5 , pp. 781-798
    • Sarma, D.S.1    Rao, P.M.2    Rajalakshmi, S.3
  • 37
    • 0021984064 scopus 로고
    • A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat
    • Roomi,M.W., Ho,R.K., Sarma,D.S.R. and Farber,E. (1985) A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat. Cancer Res., 45, 564-571.
    • (1985) Cancer Res. , vol.45 , pp. 564-571
    • Roomi, M.W.1    Ho, R.K.2    Sarma, D.S.R.3    Farber, E.4
  • 38
    • 0033836063 scopus 로고    scopus 로고
    • Technology evaluation: Valspodar, Novartis AG
    • Tai,H.L. (2000) Technology evaluation: Valspodar, Novartis AG. Curr. Opin. Mol. Ther., 2, 459-467.
    • (2000) Curr. Opin. Mol. Ther. , vol.2 , pp. 459-467
    • Tai, H.L.1
  • 39
    • 0036939821 scopus 로고    scopus 로고
    • The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice
    • Lehne,G., Sorensen,D.R., Tjonnfjord,G.E., Beiske,C., Hagve,T.A., Rugstad,H.E. and Clausen,O.P. (2002) The cyclosporin PSC 833 increases survival and delays engraftment of human multidrug-resistant leukemia cells in xenotransplanted NOD-SCID mice. Leukemia, 16, 2388-2394.
    • (2002) Leukemia , vol.16 , pp. 2388-2394
    • Lehne, G.1    Sorensen, D.R.2    Tjonnfjord, G.E.3    Beiske, C.4    Hagve, T.A.5    Rugstad, H.E.6    Clausen, O.P.7
  • 41
    • 0034231606 scopus 로고    scopus 로고
    • P-glycoprotein as a drug target in the treatment of multidrug resistant cancer
    • Lehne,G. (2000) P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Curr. Drug Targets, 1, 85-99.
    • (2000) Curr. Drug Targets , vol.1 , pp. 85-99
    • Lehne, G.1
  • 42
    • 0033958086 scopus 로고    scopus 로고
    • Multiple physiological functions for multidrug transporter P-glycoprotein?
    • Johnstone,R.W., Ruefli,A.A. and Smyth,M.J. (2000) Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem. Sci., 25, 1-6.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 1-6
    • Johnstone, R.W.1    Ruefli, A.A.2    Smyth, M.J.3
  • 43
    • 0036849351 scopus 로고    scopus 로고
    • P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
    • Ruefli,A.A., Tainton,K.M., Darcy,P.K., Smyth,M.J. and Johnstone,R.W. (2002) P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ., 9, 1266-1272.
    • (2002) Cell Death Differ. , vol.9 , pp. 1266-1272
    • Ruefli, A.A.1    Tainton, K.M.2    Darcy, P.K.3    Smyth, M.J.4    Johnstone, R.W.5
  • 44
    • 0034574938 scopus 로고    scopus 로고
    • Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of P-glycoprotein
    • Azare,J., Pankova-Kholmyansky,I., Salnikow,K., Cohen,D. and Flescher,E. (2000) Selective susceptibility of transformed T lymphocytes to induction of apoptosis by PSC 833, an inhibitor of P-glycoprotein. Oncol. Res., 12, 315-323.
    • (2000) Oncol. Res. , vol.12 , pp. 315-323
    • Azare, J.1    Pankova-Kholmyansky, I.2    Salnikow, K.3    Cohen, D.4    Flescher, E.5
  • 45
    • 0036367871 scopus 로고    scopus 로고
    • Clinical development of P glycoprotein modulators in oncology
    • 103-115
    • Oza,A.M. (2002) Clinical development of P glycoprotein modulators in oncology. Novartis Found. Symp., 243, 103-115, 180-185.
    • (2002) Novartis Found. Symp. , vol.243 , pp. 180-185
    • Oza, A.M.1
  • 47
  • 48
    • 0035030729 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic
    • Dantzig,A.H., Law,K.L., Cao,J. and Starling,J.J. (2001) Reversal of multidrug resistance by the P-glycoprotein modulator, LY335979, from the bench to the clinic. Curr. Med. Chem., 8, 39-50.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 39-50
    • Dantzig, A.H.1    Law, K.L.2    Cao, J.3    Starling, J.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.