Molecular cycloencapsulation augments solubility and improves therapeutic index of brominated noscapine in prostate cancer cells

Molecular Pharmaceutics

Volumn 9, Issue 5, 2012, Pages 1470-1480

  Madan, Jitender ^a   Baruah, Bharat ^b   Nagaraju, Mulpuri ^a   Abdalla, Mohamed O ^c   Yates, Clayton ^c   Turner, Timothy ^c   Rangari, Vijay ^c   Hamelberg, Donald ^a   Aneja, Ritu ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b KENNESAW STATE UNIVERSITY   (United States)

^c TUSKEGEE UNIVERSITY   (United States)

Author keywords

CD; cytotoxicity; dissolution; EM011; inclusion complexes; methyl CD; prostate cancer

Indexed keywords

3 (9 BROMO 4 METHOXY 6 METHYL 5,6,7,8 TETRAHYDRO [1,3]DIOXOLO [4,5 G]ISOQUINOLIN 5 YL) 6,7 DIMETHOXYISOBENZOFURAN 1 (3H) ONE; CYCLODEXTRIN; EM 011; METHYL BETA CYCLODEXTRIN; NANOPARTICLE; NOSCAPINE; PROTON; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CANCER CELL; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; DRUG STABILITY; ENCAPSULATION; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOLECULAR CYCLOENCAPSULATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHARMACOLOGICAL PARAMETERS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; SCANNING ELECTRON MICROSCOPY; STOICHIOMETRY; THERAPEUTIC INDEX; VALIDATION STUDY; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE, TUMOR; CELL SURVIVAL; CYCLODEXTRINS; DIOXOLES; HUMANS; ISOQUINOLINES; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NOSCAPINE; PROSTATIC NEOPLASMS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 84860717951     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300063v     Document Type: Article

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