Estradiol induces cytochrome P450 2B6 expression at high concentrations: Implication in estrogen-mediated gene regulation in pregnancy

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 93-103

  Koh, Kwi Hye ^a   Jurkovic, Steve ^a   Yang, Kyunghee ^a   Choi, Su Young ^a   Jung, Jin Woo ^b   Kim, Kwang Pyo ^b   Zhang, Wei ^a   Jeong, Hyunyoung ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b Konkuk University   (South Korea)

Author keywords

Cytochrome P450 2B6; Estradiol; Nuclear receptors; Pregnancy

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 2B6; ESTRADIOL; ESTROGEN RECEPTOR;

ADULT; ARTICLE; BINDING SITE; CELL STRAIN HEPG2; DNA BINDING; ENZYME ACTIVITY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ADULT; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HEP G2 CELLS; HEPATOCYTES; HUMANS; LUCIFERASES; MIDDLE AGED; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDOREDUCTASES, N-DEMETHYLATING; PREGNANCY; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, ESTROGEN; TANDEM MASS SPECTROMETRY; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTIONAL ACTIVATION;

EID: 84860676728     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.016     Document Type: Article

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