Inhibition of thymidine phosphorylase expression by using an HSP90 inhibitor potentiates the cytotoxic effect of cisplatin in non-small-cell lung cancer cells

Biochemical Pharmacology

Volumn 84, Issue 1, 2012, Pages 126-136

  Weng, Shao Hsing ^a   Tseng, Sheng Chieh ^a   Huang, Yu Ching ^a   Chen, Huang Jen ^a   Lin, Yun Wei ^a  

^a NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

Cytotoxicity; HSP90; Non small cell lung cancer; Thymidine phosphorylase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; CISPLATIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEASOME; PROTEIN KINASE B; RETASPIMYCIN; SMALL INTERFERING RNA; THYMIDINE PHOSPHORYLASE; UBIQUITIN;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DOWN REGULATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CISPLATIN; DOWN-REGULATION; DRUG SYNERGISM; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOPRECIPITATION; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THYMIDINE PHOSPHORYLASE;

EID: 84860668954     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.03.011     Document Type: Article

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