Thymidine phosphorylase suppresses Fas-induced apoptotic signal transduction independent of its enzymatic activity

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 300-305

  Mori, Shin Ichiro ^a   Takao, Sonshin ^a   Ikeda, Ryuji ^a   Noma, Hidetoshi ^a   Mataki, Yuko ^a   Wang, Xin ^a   Akiyama, Shin Ichi ^a   Aikou, Takashi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

2 Deoxy D ribose; Apo 1; Caspase 3; Caspase 8; Cd95; Cytochrome c; Disc; Thymidine; Thymidine phosphorylase inhibitor; Thymine

Indexed keywords

2 DEOXYRIBOSE; CASPASE 3; CASPASE 8; COMPLEMENTARY DNA; CYTOCHROME C; FAS ANTIGEN; THYMIDINE; THYMIDINE PHOSPHORYLASE; THYMINE;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME RELEASE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CASPASES; CYTOCHROME C GROUP; DEOXYRIBOSE; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; SIGNAL TRANSDUCTION; THYMIDINE; THYMIDINE PHOSPHORYLASE; THYMINE; TUMOR CELLS, CULTURED;

EID: 0036064768     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00662-9     Document Type: Article

References (34)

1. Angiogenic factor
2. Purification and properties of an endothelial cell growth factor from human platelets
3. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor
4. Role of thymidine phosphorylase activity in the angiogenic effect of platelet derived endothelial cell growth factor/thymidine phosphorylase
5. Angiogenic activity of enzymes
6. Kinetic studies of thymidine phosphorylase from mouse liver
7. The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors
8. Thymidine phosphorylase is angiogenic and promotes tumor growth
9. Suppression of metastasis by thymidine phosphorylase inhibitor
10. Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas
11. Expression of thymidine phosphorylase in human gastric carcinoma
12. Thymidine phosphorylase in human esophageal squamous cell carcinoma
13. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma
14. Thymidine phosphorylase, 2-deoxy-D-ribose and angiogenesis
15. Prevention of hypoxia-induced apoptosis by the angiogenic factor thymidine phosphorylase
16. Molecular basis for the inhibition of hypoxia-induced apoptosis by 2-deoxy-D-ribose
17. Programmed cell death in animal development
18. Mechanisms and genes of cellular suicide
19. The Fas death factor
20. Apoptosis by death factor
21. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
22. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
23. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
24. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
26. Cytochrome c: Can’t live with it - Can’t live without it
27. Role of thymidine phosphorylase in Fas-induced apoptosis
28. Thompson Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria
29. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
30. Caspases: Enemies within
31. Death receptors: Signaling and modulation
32. Caspases: Intracellular signaling by proteolysis
33. Inhibition of death receptor signals by cellular FLIP
34. The role of c-FLIP in modulation of CD95-induced apoptosis