Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres

EMBO Journal

Volumn 31, Issue 9, 2012, Pages 2076-2089

  Remeseiro, Silvia ^a   Cuadrado, Ana ^a   Carretero, María ^a   Mart́nez, Paula ^a   Drosopoulos, William C ^b   Cañamero, Marta ^a   Schildkraut, Carl L ^b   Blasco, Maŕa A ^a   Losada, Ana ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

cancer; chromosome segregation; cohesion; embryonic development; mouse model

Indexed keywords

COHESIN; PROTEIN STROMAL ANTIGEN 1; UNCLASSIFIED DRUG;

ABLATION THERAPY; ANEUPLOIDY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CENTROMERE; CHROMOSOME REPLICATION; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DISEASE MODEL; EMBRYO; EMBRYO DEATH; EMBRYO DEVELOPMENT; FEMALE; FIBROBLAST; FIBROSARCOMA; HETEROZYGOSITY; LIFESPAN; LIVER TUMOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; TELOMERE;

ANEUPLOIDY; ANIMALS; CARCINOGENS; CELL CYCLE PROTEINS; CELL LINE; CHROMATIDS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME SEGREGATION; DIETHYLNITROSAMINE; FIBROSARCOMA; LIVER NEOPLASMS; MALE; METHYLCHOLANTHRENE; MICE; MICE, KNOCKOUT; NEOPLASMS, EXPERIMENTAL; PROTEIN SUBUNITS; SISTER CHROMATID EXCHANGE; TELOMERE;

ANIMALIA; MUS; VERTEBRATA;

EID: 84860507563     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2012.11     Document Type: Article

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