Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus

Antiviral Research

Volumn 88, Issue 2, 2010, Pages 160-168

  Yang, Cheng Wei ^a,b   Lee, Yue Zhi ^a   Kang, Iou Jiun ^a   Barnard, Dale L ^c   Jan, Jia Tsrong ^d   Lin, Du ^a   Huang, Chun Wei ^a   Yeh, Teng Kuang ^a   Chao, Yu Sheng ^a   Lee, Shiow Ju ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c UTAH STATE UNIVERSITY   (United States)

^d GENOMICS RESEARCH CENTER   (Taiwan)

Author keywords

Coronavirus; Human severe acute respiratory syndrome coronavirus; Phenanthroindolizine; Phenanthroquinolizidine; Porcine transmissible gastroenteritis virus; Tylophorine

Indexed keywords

7 METHOXYCRYPTOPLEURINE; ANTIVIRUS AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; PHENANTHROINDOLIZINE; PHENANTHROQUINOLIZIDINE; PROTEIN S; TYLOPHORINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; IMMUNOASSAY; IMMUNOFLUORESCENCE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SARS CORONAVIRUS; STRUCTURE ACTIVITY RELATION; TRANSMISSIBLE GASTROENTERITIS VIRUS; VIRUS REPLICATION;

ALKALOIDS; ANIMALS; ANTIVIRAL AGENTS; ASCLEPIADACEAE; CERCOPITHECUS AETHIOPS; CORONAVIRUS INFECTIONS; CYTOPATHOGENIC EFFECT, VIRAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROENTERITIS, TRANSMISSIBLE, OF SWINE; INDOLIZINES; PHENANTHRENES; PHENANTHROLINES; QUINOLIZINES; RATS; RATS, SPRAGUE-DAWLEY; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; TRANSMISSIBLE GASTROENTERITIS VIRUS; TYLOPHORA; VERO CELLS;

CORONAVIRUS; RATTUS; SARS CORONAVIRUS; SUS; TRANSMISSIBLE GASTROENTERITIS VIRUS;

EID: 77958153961     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2010.08.009     Document Type: Article

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