Procoagulant and prothrombotic effects of the herbal medicine, Dipsacus asper and its active ingredient, dipsacus saponin C, on human platelets

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 5, 2012, Pages 895-906

  Song, J S ^a   Lim, K M ^a   Kang, S ^a   Noh, J Y ^a   Kim, K ^a   Bae, O N ^b   Chung, J H ^a  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Apoptosis; Dipsacus saponin C; Herbal medicine; Phosphatidylserine exposure; Platelets; Procoagulant activity; Thrombosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C; DIPSACUS ASPER EXTRACT; DIPSACUS SAPONIN C; EGTAZIC ACID; FLIPPASE; HERBACEOUS AGENT; PHOSPHATIDYLSERINE; PHOSPHOLIPID TRANSFER PROTEIN; PROCOAGULANT; PROTEIN BAK; PROTEIN BAX; SAPONIN DERIVATIVE; SCRAMBLASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD CLOTTING; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIPSACUS; DIPSACUS ASPER; DRUG ACTIVITY; DRUG ISOLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; HERBAL MEDICINE; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; RAT; VEIN THROMBOSIS;

ADENOSINE TRIPHOSPHATE; ADOLESCENT; ADULT; ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BLOOD COAGULATION; BLOOD PLATELETS; CALCIUM; CASPASE 3; CELL-DERIVED MICROPARTICLES; CHELATING AGENTS; COAGULANTS; CYTOCHROMES C; DIPSACACEAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OLEANOLIC ACID; PARTIAL THROMBOPLASTIN TIME; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; PLANT PREPARATIONS; PLANT ROOTS; PLATELET ACTIVATION; PROTHROMBIN TIME; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; RISK FACTORS; SAPONINS; THROMBOSIS; TIME FACTORS; YOUNG ADULT;

EID: 84860432109     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2012.04685.x     Document Type: Article

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