Microglia and cyclooxygenase-2: Possible therapeutic targets of progesterone for stroke

International Immunopharmacology

Volumn 11, Issue 11, 2011, Pages 1925-1931

  Jiang, Chao ^a   Cui, Kefei ^b   Wang, Jianping ^a   He, Yuanhong ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cerebral infarction; Cyclooxygenase 2; Inflammatory reaction; Mechanism; Microglia; Progesterone

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CALCIUM BINDING PROTEIN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; LIPOPOLYSACCHARIDE; PROGESTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL ACTIVATION; CELL CULTURE; CONTROLLED STUDY; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CALCIUM-BINDING PROTEINS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MICROFILAMENT PROTEINS; MICROGLIA; NEUROPROTECTIVE AGENTS; PROGESTERONE; RATS; RATS, SPRAGUE-DAWLEY; STROKE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860421206     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.08.001     Document Type: Article

References (42)

1. K. Vagnerova, I.P. Koerner, and P.D. Hurn Gender and the injured brain Anesth Analg 107 2008 201 214
2. Z. Hu, Y. Li, M. Fang, M.S. Wai, and D.T. Yew Exogenous progesterone: a potential therapeutic candidate in CNS injury and neurodegeneration Curr Med Chem 16 2009 1418 1425
3. C. Jiang, J.P. Wang, X. Li, Ch.L. Liu, N.N. Chen, and Y.J. Hao Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke Inflammation Res 58 2009 619 624
4. M. Schilling, M. Besselmann, C. Leonhard, and M. Mueller Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice Exp Neurol 183 2003 25 33 (Pubitemid 37075853)
5. M. Schilling, M. Besselmann, M. Muller, and J.K. Strecker Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice Exp Neurol 196 2005 290 297 (Pubitemid 41607817)
6. R. Filipovic, and N. Zecevic Neuroprotective role of minocycline in co-cultures of human fetal neurons and microglia Exp Neurol 211 2008 41 51
7. Y. Pang, L. Campbell, B. Zheng, L. Fan, Z. Cai, and P. Rhodes Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development Neuroscience 166 2010 464 475
8. G. Matthew, M.V. Frank, D.B. Baratta, L.R. Sprunger, and S.F. Watkins Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses Brain Behav Immun 21 2007 47 59
9. R. Pola Inflammatory markers for ischaemic stroke Thromb Haemost 101 2009 800 801
10. H.E. de Vries, M.C. Blom-Roosemalen, and O.M. van The influence of cytokines on the integrity of the blood brain barrier in vitro J Neuroimmunol 64 2007 37 43
11. J. Shen, H. Zhang, and H. Lin Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression Eur J Pharmacol 558 2007 88 95 (Pubitemid 46328876)
12. X. Liang, L. Wu, Q. Wang, T. Hand, M. Bilak, and L. McCullough Function of COX-2 and prostaglandins in neurological disease J Mol Neurosci 33 2007 94 99 (Pubitemid 47574964)
13. A. Cherubini, M. Carmelinda Ruggiero, C. Polidori, and P. Mecocci Potential markers of oxidative stress in stroke Free Radic Biol Med 39 2005 841 852
14. H.S. Kim, I.H. Cho, J.E. Kim, Y.J. Shin, J.H. Jeon, and Y. Kim Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia Free Radic Biol Med 45 2008 950 963
15. E. Gonzalez-Rey, and D. Mario Vasoactive intestinal peptide inhibits cyclooxygenase-2 expression in activated macrophages, microglia, and dendritic cells Brain Behav Immun 22 2008 5 41
16. E. Araki, C. Forster, J.M. Dubinsky, M.E. Ross, and C. Iadecola Cyclooxygenase-2 inhibitor ns-398 protects neuronal cultures from lipopolysaccharide-induced neurotoxicity Stroke 32 2001 2370 2375 (Pubitemid 32954810)
17. W. Yin, E.B. Ahmed, G. Mychaskiw, and J.H. Zhang Down regulation of COX-2 is involved in hyperbaric oxygen treatment in a rat transient focal cerebral ischemia model Brain Res 926 2002 165 171 (Pubitemid 34117602)
18. N. Jiang, M. Chopp, D. Stein, and H. Feit Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats Brain Res 735 1996 101 107 (Pubitemid 26336624)
19. K.J. Grossman, C.W. Goss, and D.G. Stein Effects of progesterone on the inflammatory response to brain injury in the rat Brain Res 1008 2004 29 39 (Pubitemid 38469973)
20. M. Schumacher, and F. Robert Progesterone: synthesis, metabolism, mechanisms of action, and effects in the nervous system Horm Brain Behav 2002 683 745
21. G. Levi, M. Patrizio, A. Bernardo, T.C. Petrucci, and C. Agresti Human immunodeficiency virus coat protein gp120 inhibits the beta-adrenergic regulation of astroglial and microglial functions Proc Natl Acad Sci USA 90 1993 1541 1545 (Pubitemid 23058209)
22. N. Benedetto, F. Rossano, F. Gorga, A. Folgore, M. Rao, and C. Romano Carratelli Defense mechanisms of IFN-gamma and LPS-primed murine microglia against Acanthamoeba castellanii infection Int Immunopharmacol 3 2003 825 834 (Pubitemid 36629448)
23. M. Djebaili, Q. Guo, and E.H. Pettus The neurosteroids progesterone and allopregnanolone reduce cell death, gliosis, and functional deficits after traumatic brain injury in rats J Neurotrauma 22 2005 106 118
24. Y. Kumon, S.C. Kim, and P. Tompkins Neuroprotective effect of postischemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischemia J Neurosurg 92 2000 848 852 (Pubitemid 30243934)
25. D.G. Stein Progesterone exerts neuroprotective effects after brain injury Brain Res Rev 57 2008 386 397 (Pubitemid 351381771)
26. D.B. Dubal, P.J. Shughrue, M.E. Wilson, I. Merchenthaler, and P.M. Wise Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors J Neurosci 19 1999 6385 6393 (Pubitemid 29347438)
27. J. He, C.O. Evans, S.W. Hoffman, N.M. Oyesiku, and D.G. Stein Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury Exp Neurol 189 2004 404 412 (Pubitemid 39221832)
28. I. Sayeed, B. Wali, and D.G. Stein Progesterone inhibits ischemic brain injury in a rat model of permanent middle cerebral artery occlusion Restor Neurol Neurosci 25 2007 151 159 (Pubitemid 47290443)
29. R. Galani, S.W. Hoflhlan, and D.G. Stein Effects of the duration of progesterone treatment on the resolution of cerebral edema induced by cortical contusion in rats Neurosci 18 2001 161 166 (Pubitemid 34258569)
30. C.W. Goss, S.W. Hoffman, and D.G. Stein Behavioral effects and anatomic correlates after brain injury: a progesterone dose-response study Pharmacol Biochem Behav 76 2003 231 242 (Pubitemid 37329844)
31. C.D. Munhoz, B. García-Bueno, J.L. Madrigal, L.B. Lepsch, C. Scavone, and J.C. Leza Stress-induced neuroinflammation: mechanisms and new pharmacological targets Braz J Med Bio Res 41 2008 1037 1046
32. G. Stoll, and S. Jander The role of microglia and macrophages in the pathophysiology of the CNS Prog Neurobiol 58 1999 233 247 (Pubitemid 29193056)
33. R.S. Nicholas, S. Stevens, M.G. Wing, and D.A. Compston Microglia-derived IGF-2 prevents TNFα induced death of mature oligodendrocytes in vitro J Neuroimmunol 124 2002 36 44 (Pubitemid 34212008)
34. C.T. Ekdahl, Z. Kokaia, and O. Lindvall Brain inflammation and adult neurogenesis: the dual role of microglia Neurosci 158 2009 1021 1029
35. M. Schilling, J.K. Strecker, E.B. Ringelstein, W.R. Schäbitz, and R. Kiefer The role of CC chemokine receptor on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice Brain Res 1289 2009 79 84
36. M. Chopp, R.L. Zhang, H. Chen, Y. Li, N. Jiang, and J.R. Rusche Post-ischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats Stroke 25 1994 869 875
37. R. Bianchi, I. Giambanco, and R.S. Donato 100B/RAGE-dependent activation of microglia via NF-kappaB and AP-1 co-regulation of COX-2 expression by S100B, IL-1beta and TNF-alpha Neurobiol Aging 31 2010 665 677
38. D. Wu, M. Osamu, S. Sei, O. Maiko, and I. Hiroharu Different expression of macrophages and microglia in rat spinal cord contusion injury model at morphological and reginal levels Acta Med 59 2005 121 127 (Pubitemid 41355152)
39. E. Candelario-Jalil, and B.L. Fiebich Cyclooxygenase inhibition in ischemic brain injury Curr Pharm Des 14 2008 1401 1418 (Pubitemid 351982548)
40. M. Ahmad, Y. Zhang, H. Liu, M.E. Rose, and S.H. Graham Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity Brain Res 1279 2009 168 173
41. R.L. Roof, S.W. Hoffman, and D.G. Stein Progesterone protects against lipid peroxidation following traumatic brain injury in rats Mol Chem Neuropathol 31 1997 1 11 (Pubitemid 27328632)
42. Y.L. Xing, W.N. Chen, and S.Q. Li Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats Neurochem Res 34 2009 1451 1463