Prolonged opportunity for neuroprotection in experimental stroke with selective blockade of cyclooxygenase-2 activity

Brain Research

Volumn 1279, Issue , 2009, Pages 168-173

  Ahmad, Muzamil ^a,b   Zhang, Yuquin ^a,b   Liu, Hao ^a,b   Rose, Marie E ^a,b   Graham, Steven H ^a,b  

^a VA Pittsburgh Healthcare System   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cerebral ischemia; Clinical significance; COX 2 inhibitor; Therapeutic window; Valdecoxib

Indexed keywords

CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; PROSTAGLANDIN E2; THROMBOXANE B2; VALDECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL; NEUROPROTECTION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE; WESTERN BLOTTING;

ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; BRAIN; CEREBROVASCULAR CIRCULATION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; INFARCTION, MIDDLE CEREBRAL ARTERY; ISOXAZOLES; MALE; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; THROMBOXANE B2; TIME FACTORS;

RATTUS;

EID: 67649410136     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.05.020     Document Type: Article

References (28)

1. Ahmad A.S., Saleem S., Ahmad M., and Dore S. Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol. Sci. 89 (2006) 265-270
2. Ahmad M., Saleem S., Zhuang H., Ahmad A.S., Echeverria V., Sapirstein A., and Dore S. 1-hydroxyPGE reduces infarction volume in mouse transient cerebral ischemia. Eur. J. Neurosci. 23 (2006) 35-42
3. Candelario-Jalil E., and Fiebich B.L. Cyclooxygenase inhibition in ischemic brain injury. Curr. Pharm. Des. 14 (2008) 1401-1418
4. Candelario-Jalil E., Gonzalez-Falcon A., Garcia-Cabrera M., Leon O.S., and Fiebich B.L. Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat. Brain Res. 1007 (2004) 98-108
5. Candelario-Jalil E., Gonzalez-Falcon A., Garcia-Cabrera M., Leon O.S., and Fiebich B.L. Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats. J. Neurochem. 100 (2007) 1108-1120
6. del Zoppo G., Ginis I., Hallenbeck J.M., Iadecola C., Wang X., and Feuerstein G.Z. Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol. 10 (2000) 95-112
7. Dore S. GPCR antagonists as an alternative to COX-2 inhibitors: a case for the PGE2 EP1 receptor. Trends Pharmacol. Sci. 27 (2006) 458-460
8. Dore S., Otsuka T., Mito T., Sugo N., Hand T., Wu L., Hurn P.D., Traystman R.J., and Andreasson K. Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann. Neurol. 54 (2003) 155-162
9. Graff J., Skarke C., Klinkhardt U., Watzer B., Harder S., Seyberth H., Geisslinger G., and Nusing R.M. Effects of selective COX-2 inhibition on prostanoids and platelet physiology in young healthy volunteers. J. Thromb. Haemost. 5 (2007) 2376-2385
10. Hara K., Kong D.L., Sharp F.R., and Weinstein P.R. Effect of selective inhibition of cyclooxygenase 2 on temporary focal cerebral ischemia in rats. Neurosci. Lett. 256 (1998) 53-56
11. Hata A.N., and Breyer R.M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103 (2004) 147-166
12. Iadecola C., Niwa K., Nogawa S., Zhao X., Nagayama M., Araki E., Morham S., and Ross M.E. Reduced susceptibility to ischemic brain injury and N-methyl-d-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 1294-1299
13. Kaufmann W.E., Worley P.F., Pegg J., Bremer M., and Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 2317-2321
14. Kawano T., Anrather J., Zhou P., Park L., Wang G., Frys K.A., Kunz A., Cho S., Orio M., and Iadecola C. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat. Med. 12 (2006) 225-229
15. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 79 (1999) 1431-1568
16. Longa E.Z., Weinstein P.R., Carlson S., and Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989) 84-91
17. McCullough L., Wu L., Haughey N., Liang X., Hand T., Wang Q., Breyer R.M., and Andreasson K. Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia. J. Neurosci. 24 (2004) 257-268
18. Miettinen S., Fusco F.R., Yrjanheikki J., Keinanen R., Hirvonen T., Roivainen R., Narhi M., Hokfelt T., and Koistinaho J. Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-d-aspartic acid-receptors and phospholipase A2. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 6500-6505
19. Minghetti L. Role of COX-2 in inflammatory and degenerative brain diseases. Subcell. Biochem. 42 (2007) 127-141
20. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., and Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 10954-10959
21. Nogawa S., Zhang F., Ross E., and Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 14 (1997) 2746-2755
22. Nogawa S., Zhang F., Ross M.E., and Iadecola C. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J. Neurosci. 17 (1997) 2746-2755
23. Planas A.M., Soriano M.A., Rodriguez-Farre E., and Ferrer I. Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain. Neurosci. Lett. 200 (1995) 187-190
24. Poloyac S.M., Zhang Y., Bies R.R., Kochanek P.M., and Graham S.H. Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia. J. Cereb. Blood Flow Metab. 26 (2006) 1551-1561
25. Spektor G., and Fuster V. Drug insight: cyclo-oxygenase 2 inhibitors and cardiovascular risk-where are we now?. Nat. Clin. Pract. Cardiovasc. Med. 2 (2005) 290-300
26. Sugimoto K., and Iadecola C. Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia. Brain Res. 960 (2003) 273-276
27. Sugimoto Y., and Narumiya S. Prostaglandin E receptors. J. Biol. Chem. 282 (2007) 11613-11617
28. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., and Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 11 (1993) 371-386