Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil

Fertility and Sterility

Volumn 96, Issue 4, 2011, Pages 974-979

  Ramos, Ramon Bossardi ^a,b   Casanova, Gislaine Krolow ^a,b   Maturana, Maria Augusta ^a,b   Spritzer, Poli Mara ^a,b,c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b National Institute of Hormones and Women's Health   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

cardiovascular risk; FTO gene polymorphism; glucose levels; LAP; menopause

Indexed keywords

ADULT; ALLELE; ARTICLE; BLOOD PRESSURE; BLOOD SAMPLING; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR RISK; FEMALE; FTO GENE; GENE; GENE FREQUENCY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; LIPID STORAGE; METABOLIC PARAMETERS; OBESITY; POSTMENOPAUSE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE;

ANTHROPOMETRY; BLOOD GLUCOSE; BODY FAT DISTRIBUTION; BRAZIL; CROSS-SECTIONAL STUDIES; FEMALE; GENETIC VARIATION; HUMANS; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; PROTEINS;

EID: 84860415025     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.07.1148     Document Type: Article

References (50)

1. V. Regitz-Zagrosek, E. Lehmkuhl, and S. Mahmoodzadeh Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease Gend Med 4 Suppl B 2007 S162 S177
2. H. Mangge, W. Renner, G. Almer, D. Weghuber, R. Moller, and R. Horejsi Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents J Obes 2011 2011 1 4
3. R.M. Freathy, N.J. Timpson, D.A. Lawlor, A. Pouta, Y. Ben-Shlomo, and A. Ruokonen Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI Diabetes 57 2008 1419 1426
4. T. Ahmad, D.I. Chasman, S. Mora, G. Pare, N.R. Cook, and J.E. Buring The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women Am Heart J 160 2010 1163 1169
5. S. Karasawa, M. Daimon, S. Sasaki, S. Toriyama, T. Oizumi, and S. Susa Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population Endocrine journal 57 2010 293 301
6. E. Fisher, M.B. Schulze, N. Stefan, H.U. Haring, F. Doring, and H.G. Joost Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels Obesity (Silver Spring) 17 2009 330 334
7. Y. Sun, J. Sun, X. Wang, W. You, and M. Yang Variants in the fat mass and obesity associated (FTO) gene are associated with obesity and C-reactive protein levels in Chinese Han populations Clin Invest Med 33 2010 E405 E412
8. J.A. Jacobsson, J. Klovins, I. Kapa, P. Danielsson, V. Svensson, and M. Ridderstrale Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents Int J Obes (2005) 32 2008 1730 1735
9. J.R. Speakman, K.A. Rance, and A.M. Johnstone Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure Obesity (Silver Spring) 16 2008 1961 1965
10. A. Haupt, C. Thamer, H. Staiger, O. Tschritter, K. Kirchhoff, and F. Machicao Variation in the FTO gene influences food intake but not energy expenditure Exp Clin Endocrinol Diabetes 117 2009 194 197
11. A. Jonsson, F. Renstrom, V. Lyssenko, E.C. Brito, B. Isomaa, and G. Berglund Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults Diabetologia 52 2009 1334 1338
12. Y. Song, N.C. You, Y.H. Hsu, B.V. Howard, R.D. Langer, and J.E. Manson FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women Obesity (Silver Spring) 16 2008 2472 2480
13. M. Toscani, R. Migliavacca, J.A. Sisson de Castro, and P.M. Spritzer Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: A pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome Metabolism 56 2007 992 997 (Pubitemid 46890983)
14. Y. Yagil, and C. Yagil Estrogen-related genes and blood pressure: an example of the complexity of advanced association studies J Hypertens 23 2005 2147 2149 (Pubitemid 41666742)
15. G.B. Donato, S.C. Fuchs, K. Oppermann, C. Bastos, and P.M. Spritzer Association between menopause status and central adiposity measured at different cutoffs of waist circumference and waist-to-hip ratio Menopause 13 2006 280 285
16. A.V. Chobanian, G.L. Bakris, H.R. Black, W.C. Cushman, L.A. Green, and J.L. Izzo Jr. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report JAMA 289 2003 2560 2572 (Pubitemid 37430158)
17. NCEP/ATPIII Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) JAMA 285 2001 2486 2497
18. W.T. Friedewald, R.I. Levy, and D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 1972 499 502
19. A. Katz, S.S. Nambi, K. Mather, A.D. Baron, D.A. Follmann, and G. Sullivan Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans J Clin Endocrinol Metab 85 2000 2402 2410 (Pubitemid 32269192)
20. H.S. Kahn The "lipid accumulation product" performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison BMC Cardiovasc Disord 5 2005 26
21. G. Casanova, S. Radavelli, F. Lhullier, and P.M. Spritzer Effects of nonoral estradiol-micronized progesterone or low-dose oral estradiol- drospirenone therapy on metabolic variables and markers of endothelial function in early postmenopause Fertil Steril 92 2009 605 612
22. S.A. Miller, D.D. Dykes, and H.F. Polesky A simple salting out procedure for extracting DNA from human nucleated cells Nucleic Acids Res 16 1988 1215
23. T.M. Frayling, N.J. Timpson, M.N. Weedon, E. Zeggini, R.M. Freathy, and C.M. Lindgren A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity Science 316 2007 889 894 (Pubitemid 46764279)
24. K. Hotta, Y. Nakata, T. Matsuo, S. Kamohara, K. Kotani, and R. Komatsu Variations in the FTO gene are associated with severe obesity in the Japanese J Hum Genet 53 2008 546 553 (Pubitemid 351749344)
25. C.H. Andreasen, K.L. Stender-Petersen, M.S. Mogensen, S.S. Torekov, L. Wegner, and G. Andersen Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation Diabetes 57 2008 95 101
26. K. Wahlen, E. Sjolin, and J. Hoffstedt The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis J Lipid Res 49 2008 607 611
27. A. Peeters, S. Beckers, A. Verrijken, P. Roevens, P. Peeters, and L. Van Gaal Variants in the FTO gene are associated with common obesity in the Belgian population Mol Genet Metab 93 2008 481 484 (Pubitemid 351381467)
28. A. Tonjes, E. Zeggini, P. Kovacs, Y. Bottcher, D. Schleinitz, and K. Dietrich Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany Eur J Hum Genet 18 2010 104 110
29. National Institutes of Health. International HapMap Project. Available at: http://www.ncbi.nlm.nih.gov. Last accessed August 18, 2011.
30. C. Dina, D. Meyre, S. Gallina, E. Durand, A. Korner, and P. Jacobson Variation in FTO contributes to childhood obesity and severe adult obesity Nat Genet 39 2007 724 726 (Pubitemid 46848595)
31. T. Gerken, C.A. Girard, Y.C. Tung, C.J. Webby, V. Saudek, and K.S. Hewitson The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase Science 318 2007 1469 1472 (Pubitemid 350208961)
32. R. Fredriksson, M. Hagglund, P.K. Olszewski, O. Stephansson, J.A. Jacobsson, and A.M. Olszewska The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain Endocrinology 149 2008 2062 2071 (Pubitemid 351574484)
33. J.E. Cecil, R. Tavendale, P. Watt, M.M. Hetherington, and C.N. Palmer An obesity-associated FTO gene variant and increased energy intake in children N Engl J Med 359 2008 2558 2566
34. J. Wardle, S. Carnell, C.M. Haworth, I.S. Farooqi, S. O'Rahilly, and R. Plomin Obesity associated genetic variation in FTO is associated with diminished satiety J Clin Endocrinol Metab 93 2008 3640 3643
35. N.J. Timpson, P.M. Emmett, T.M. Frayling, I. Rogers, A.T. Hattersley, and M.I. McCarthy The fat mass- and obesity-associated locus and dietary intake in children Am J Clin Nutr 88 2008 971 978
36. G. Stratigopoulos, S.L. Padilla, C.A. LeDuc, E. Watson, A.T. Hattersley, and M.I. McCarthy Regulation of Fto/Ftm gene expression in mice and humans Am J Physiol Regul Integr Comp Physiol 294 2008 R1185 R1196
37. V. Legry, D. Cottel, J. Ferrieres, D. Arveiler, N. Andrieux, and A. Bingham Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA study Metabolism 58 2009 971 975
38. J. Bressler, W.H. Kao, J.S. Pankow, and E. Boerwinkle Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study PLoS One 5 2010 e10521
39. T. Lappalainen, M. Kolehmainen, U.S. Schwab, A.M. Tolppanen, A. Stancakova, and J. Lindstrom Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism - the Finnish Diabetes Prevention Study Nutr Metab Cardiovasc Dis 1 2010 1 8
40. S.C. Hunt, S. Stone, Y. Xin, C.A. Scherer, C.L. Magness, and S.P. Iadonato Association of the FTO gene with BMI Obesity (Silver Spring) 16 2008 902 904 (Pubitemid 351465652)
41. B. Xi, Y. Shen, M. Zhang, X. Liu, X. Zhao, and L. Wu The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China BMC Med Genet 11 2011 107
42. Z. Pausova, C. Syme, M. Abrahamowicz, Y. Xiao, G.T. Leonard, and M. Perron A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians Circ Cardiovasc Genet 2 2009 260 269
43. J. Fischer, L. Koch, C. Emmerling, J. Vierkotten, T. Peters, and J.C. Bruning Inactivation of the Fto gene protects from obesity Nature 458 2009 894 898
44. J. Wen, T. Ronn, A. Olsson, Z. Yang, B. Lu, and Y. Du Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort PLoS One 5 2010 e9153
45. X. Han, Y. Luo, Q. Ren, X. Zhang, F. Wang, and X. Sun Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population BMC Med Genet 11 2010 81
46. H.S. Kahn, and R. Valdez Metabolic risks identified by the combination of enlarged waist and elevated triacylglycerol concentration Am J Clin Nutr 78 2003 928 934 (Pubitemid 39663468)
47. E. Wehr, S. Pilz, B.O. Boehm, W. Marz, and B. Obermayer-Pietsch The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women 2011 Obesity Silver Spring
48. M. Bozorgmanesh, F. Hadaegh, and F. Azizi Predictive performances of lipid accumulation product vs. adiposity measures for cardiovascular diseases and all-cause mortality, 8.6-year follow-up: Tehran Lipid and Glucose Study Lipids Health Dis 9 2011 100
49. D. Wiltgen, I.G. Benedetto, L.S. Mastella, and P.M. Spritzer Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome Hum Reprod 24 2009 1726 1731
50. E. Zimmermann, K. Skogstrand, D.M. Hougaard, A. Astrup, T. Hansen, and O. Pedersen Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index PLoS One 6 2011 e15958