MUC1/A and MUC1/B splice variants differentially regulate inflammatory cytokine expression

Experimental Eye Research

Volumn 93, Issue 5, 2011, Pages 649-657

  Imbert Fernandez, Yoannis ^a   Radde, Brandie N ^a   Teng, Yun ^a   Young, William W ^a   Hu, Chuan ^a   Klinge, Carolyn M ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Dry eye disease; IL 1 ; IL 8; MiR 21; TGF ; TNF

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 8; LUCIFERASE; MICRORNA 21; MUCIN 1; MUCIN 1A; MUCIN 1B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME ACTIVITY; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETIC VARIABILITY; GENOTYPE; INFLAMMATION; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ALTERNATIVE SPLICING; ANIMALS; BLOTTING, WESTERN; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; COS CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-8; MICRORNAS; MUCIN-1; NF-KAPPA B; PHENOTYPE; PLASMIDS; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84860402648     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.08.004     Document Type: Article

References (46)

1. Abe M., Kufe D. Structural analysis of the DF3 human breast carcinoma-associated protein. Cancer Res. 1989, 49:2834-2839.
2. Ahmad R., Raina D., Trivedi V., Ren J., Rajabi H., Kharbanda S., Kufe D. MUC1 oncoprotein activates the I[kappa]B kinase [beta] complex and constitutive NF-[kappa]B signalling. Nat. Cell Biol. 2007, 9:1419-1427.
3. Albertsmeyer A.-C., Kakkassery V., Spurr-Michaud S., Beeks O., Gipson I.K. Effect of pro-inflammatory mediators on membrane-associated mucins expressed by human ocular surface epithelial cells. Exp. Eye Res. 2010, 90:444-451.
4. Argueso P., Guzman-Aranguez A., Mantelli F., Cao Z., Ricciuto J., Panjwani N. Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier. J. Biol. Chem. 2009, 284:23037-23045.
5. Barabino S., Dana M.R. Dry eye syndromes. Chem. Immunol. Allergy 2007, 92:176-184.
6. Burdick M.D., Harris A., Reid C.J., Iwamura T., Hollingsworth M.A. Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J. Biol. Chem. 1997, 272:24198-24202.
7. Carson D.D. The cytoplasmic tail of MUC1: a very busy place. Sci. Signal. 2008, 1:pe35.
8. De Paiva C.S., Chotikavanich S., Pangelinan S.B., Pitcher J.D., Fang B., Zheng X., Ma P., Farley W.J., Siemasko K.F., Niederkorn J.Y., Stern M.E., Li D.Q., Pflugfelder S.C. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009, 2:243-253.
9. Dougherty S.M., Mazhawidza W., Bohn A.R., Robinson K.A., Mattingly K.A., Blankenship K.A., Huff M.O., McGregor W.G., Klinge C.M. Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells. Endocr-Relat Cancer 2006, 13:113-134.
10. Gendler S.J. MUC1, the renaissance molecule. J. Mammary Gland Biol. Neoplasia 2001, 6:339-353.
11. Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.N., Wilson D. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem. 1990, 265:15286-15293.
12. Guang W., Ding H., Czinn S.J., Kim K.C., Blanchard T.C., Lillehoj E.P. MUC1 cell surface mucin attenuates epithelial inflammation in response to a common mucosal pathogen. J. Biol. Chem. 2010.
13. Hilliard A., Hilliard B., Zheng S.-J., Sun H., Miwa T., Song W., Goke R., Chen Y.H. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J. Immunol. 2006, 177:8095-8102.
14. Hollingsworth M.A., Swanson B.J. Mucins in cancer: protection and control of the cell surface. Nat. Rev. Cancer 2004, 4:45-60.
15. Hong S., Lee H.J., Kim S.J., Hahm K.B. Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling. World J. Gastroenterol. 2010, 16:2080-2093.
16. Imbert Y., Darling D.S., Jumblatt M.M., Foulks G.N., Couzin E.G., Steele P.S., Young J.W.W. MUC1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controls. Exp. Eye Res. 2006, 83:493-501.
17. Imbert Y., Foulks G.N., Brennan M.D., Jumblatt M.M., John G., Shah H.A., Newton C., Pouranfar F., Young W.W. MUC1 and estrogen receptor [alpha] gene polymorphisms in dry eye patients. Exp. Eye Res. 2009, 88:334-338.
18. Jonckheere N., Van Seuningen I. The membrane-bound mucins: from cell signalling to transcriptional regulation and expression in epithelial cancers. Biochimie 2010, 92:1-11.
19. Kufe D., Inghirami G., Abe M., Hayes D., Justi-Wheeler H., Schlom J. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 1984, 3:223-232.
20. Lane B.R., Liu J., Bock P.J., Schols D., Coffey M.J., Strieter R.M., Polverini P.J., Markovitz D.M. Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. J. Virol. 2002, 76:11570-11583.
21. Levitin F., Stern O., Weiss M., Gil-Henn C., Ziv R., Prokocimer Z., Smorodinsky N.I., Rubinstein D.B., Wreschner D.H. The MUC1 sea module is a self-cleaving domain. J. Biol. Chem. 2005, 280:33374-33386.
22. Ligtenberg M.J., Vos H.L., Gennissen A.M., Hilkens J. Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J. Biol. Chem. 1990, 265:5573-5578.
23. Lu W., Hisatsune A., Koga T., Kato K., Kuwahara I., Lillehoj E.P., Chen W., Cross A.S., Gendler S.J., Gewirtz A.T., Kim K.C. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J. Immunol. 2006, 176:3890-3894.
24. Macao B., Johansson D.G., Hansson G.C., Hard T. Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat. Struct. Mol. Biol. 2006, 13:71-76.
25. McCartney-Francis N.L., Mizel D.E., Frazier-Jessen M., Kulkarni A.B., McCarthy J.B., Wahl S.M. Lacrimal gland inflammation is responsible for ocular pathology in TGF-beta 1 null mice. Am. J. Pathol. 1997, 151:1281-1288.
26. Obermair A., Schmid B.C., Packer L.M., Leodolter S., Birner P., Ward B.G., Crandon A.J., McGuckin M.A., Zeillinger R. Expression of MUC1 splice variants in benign and malignant ovarian tumours. Int. J. Cancer 2002, 100:166-171.
27. Park H., Hyun S.W., Kim K.C. Expression of MUC1 mucin gene by hamster tracheal surface epithelial cells in primary culture. Am. J. Respir. Cell Mol. Biol. 1996, 15:237-244.
28. Pflugfelder S.C. Antiinflammatory therapy for dry eye. Am. J. Ophthalmol. 2004, 137:337-342.
29. Pflugfelder S.C., Jones D., Ji Z., Afonso A., Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren's syndrome keratoconjunctivitis sicca. Curr. Eye Res. 1999, 19:201-211.
30. Rocha E.M., Wickham L.A., Huang Z., Toda I., Gao J., da Silveira L.A., Sullivan D.A. Presence and testosterone influence on the levels of anti- and pro-inflammatory cytokines in lacrimal tissues of a mouse model of Sjogren's syndrome. Adv. Exp. Med. Biol. 1998, 438:485-491.
31. Roggli E., Britan A., Gattesco S., Lin-Marq N., Abderrahmani A., Meda P., Regazzi R. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic β-cells. Diabetes 2010, 59:978-986.
32. Schmid B.C., Rudas M., Fabjani G., Speiser P., Kaserer K., Leodolter S., Zeillinger R. Evaluation of MUC1 splice variants as prognostic markers in patients with ductal carcinoma in situ of the breast. Oncol. Rep. 2003, 10:1981-1985.
33. Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
34. Schroeder J.A., Thompson M.C., Gardner M.M., Gendler S.J. Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J. Biol. Chem. 2001, 276:13057-13064.
35. Sonoda S., Uchino E., Nakao K., Sakamoto T. Inflammatory cytokine of basal and reflex tears analysed by multicytokine assay. Br. J. Ophthalmol. 2006, 90:120-122.
36. Strawbridge R.J., Nister M., Brismar K., Gronberg H., Li C. MUC1 as a putative prognostic marker for prostate cancer. Biomark Insights 2008, 3:303-315.
37. Thathiah A., Brayman M., Dharmaraj N., Julian J.J., Lagow E.L., Carson D.D. Tumor necrosis factor {alpha} stimulates MUC1 synthesis and ectodomain release in a human uterine epithelial cell line. Endocrinology 2004, 145:4192-4203.
38. Ueno K., Koga T., Kato K., Golenbock D.T., Gendler S.J., Kai H., Kim K.C. MUC1 mucin is a negative regulator of toll-like receptor signaling. Am. J. Respir. Cell Mol. Biol. 2008, 38:263-268.
39. Wang H., Lillehoj E.P., Kim K.C. Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail. Biochem. Biophys. Res. Commun. 2003, 310:341-346.
40. Wei X., Xu H., Kufe D. MUC1 oncoprotein stabilizes and activates estrogen receptor [alpha]. Mol. Cell 2006, 21:295-305.
41. Wickramasinghe N., Manavalan T., Dougherty S., Riggs K., Li Y., Klinge C. Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. Nucleic Acids Res. 2009, 37:2584-2595.
42. Williams S.J., McGuckin M.A., Gotley D.C., Eyre H.J., Sutherland G.R., Antalis T.M. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res. 1999, 59:4083-4089.
43. Wreschner D.H., Hareuveni M., Tsarfaty I., Smorodinsky N., Horev J., Zaretsky J., Kotkes P., Weiss M., Lathe R., Dion A., et al. Human epithelial tumor antigen cDNA sequences. Differential splicing may generate multiple protein forms. Eur. J. Biochem. 1990, 189:463-473.
44. Yasuda M., Nishizawa T., Ohigashi H., Tanaka T., Hou D.-X., Colburn N.H., Murakami A. Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. Carcinogenesis 2009, 30:1209-1216.
45. Zheng X., Bian F., Ma P., De Paiva C.S., Stern M., Pflugfelder S.C., Li D.-Q. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J. Cell. Physiol. 2010, 222:95-102.
46. Zrihan-Licht S., Baruch A., Elroy-Stein O., Keydar I., Wreschner D.H. Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins cytokine receptor-like molecules. FEBS Lett. 1994, 356:130-136.