Identification of four sites of stimulated tyrosine phosphorylation in the MUC1 cytoplasmic tail

Biochemical and Biophysical Research Communications

Volumn 310, Issue 2, 2003, Pages 341-346

  Wang, Honghe ^a   Lillehoj, Erik P ^a   Kim, K Chul ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Epithelial; Mucin; Signal transduction; Tyrosine kinase

Indexed keywords

CD8 ANTIGEN; CHIMERIC PROTEIN; MUCIN 1; TYROSINE;

ARTICLE; EMBRYO; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

EID: 0141459073     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.030     Document Type: Article

References (35)

1. Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.N., Wilson D. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem. 265:1990;15286-15293.
2. Lan M.S., Batra S.K., Qi W.N., Metzgar R.S., Hollingsworth M.A. Cloning and sequencing of a human pancreatic tumor mucin cDNA. J. Biol. Chem. 265:1990;15294-15299.
3. Ligtenberg M.J.L., Vos H.L., Gennissen A.M.C., Hilkens J. Episialin, a carcinoma associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J. Biol. Chem. 265:1990;5573-5578.
4. Gendler S.J. MUC1, the renaissance molecule. J. Mammary Gland Biol. Neoplasia. 6:2001;339-353.
5. Pemberton L., Taylor-Papadimitriou J., Gendler S.J. Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals. Biochem. Biophys. Res. Commun. 185:1992;167-175.
6. Zrihan-Licht S., Baruch A., Elroy-Stein O., Keydar I., Wreschner D.H. Tyrosine phosphorylation of the MUC1 breast cancer membrane protein. Cytokine receptor-like molecule. FEBS Lett. 356:1994;130-136.
7. Carraway K.L., Ramsause V.P., Haq B., Carraway C.A.C. Cell signaling through membrane mucins. BioEssays. 25:2002;66-71.
8. Meerzaman D., Xing P.X., Kim K.C. Construction and characterization of a chimeric receptor containing the cytoplasmic domain of MUC1 mucin. Am. J. Physiol. (Lung Cell. Mol. Physiol.). 278:2000;L625-L629.
9. Meerzaman D., Shapiro P., Kim K.C. Involvement of the MAP kinase ERK2 in Muc1 mucin signaling. Am. J. Physiol. (Lung Cell. Mol. Physiol.). 281:2001;L86-L91.
10. Pandy P., Kharbanda S., Kufe D. Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. Cancer Res. 55:1995;4000-4003.
11. Li Y., Bharti A., Chen D., Gong J., Kufe D. Interaction of glycogen synthase kinase 3β with the DF3/MUC1 carcinoma-associated antigen and β-catenin. Mol. Cell. Biol. 18:1998;7216-7224.
12. Baruch A., Hartmann M.L., Yoeli M., Adereth Y., Greenstein S., Stadler Y., Skornik Y., Zaretsky J., Smorodinsky N.I., Keydar I., Wreschner D.H. The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein. Cancer Res. 59:1999;1552-1561.
13. Quinn R.J., McGuckin M.A. Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion. Int. J. Cancer. 87:2000;499-506.
14. Schroeder J.A., Thompson M.C., Gardner M.M., Gendler S.J. Transgenic MUC1 interacts with EGFR and correlates with MAP kinase activation in mouse mammary gland. J. Biol. Chem. 276:2001;13057-13064.
15. Li Y., Kuwahara H., Ren J., Wen G., Kufe D. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3β and β-catenin. J. Biol. Chem. 276:2001;6061-6064.
16. Li Y., Ren J., Yu W.H., Li Q., Kuwahara H., Li Y., Carraway K.L., Kufe D. The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and β-catenin. J. Biol. Chem. 276:2001;35239-35242.
17. Wykes M., MacDonald K.P.A., Tran M., Quin R.J., Xing P.X., Gendler S.J., Hart D.N.J., McGuckin M.A. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. J. Leukoc. Biol. 72:2002;692-701.
18. Li Y., Chen W., Ren J., Yu W.H., Li Q., Yoshida K., Kufe D. DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol. Ther. 2:2003;187-193.
19. Bradford B. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
20. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature. 227:1970;680-685.
21. Songyang Z., Shoelson S.E., Chaudhuri M., Gish G., Pawson T., Haser W.G., King F., Roberts T., Ratnofsky S., Lechleider R.J. SH2 domains recognize specific phosphopeptide sequences. Cell. 72:1993;767-778.
22. Kessels H.W., Ward A.C., Schumacher T.N. Specificity and affinity motifs for Grb2 SH2-ligand interactions. Proc. Natl. Acad. Sci. USA. 99:2002;8524-8529.
23. Wymann M.P., Pirola L. Structure and function of phosphoinositide 3-kinases. Biochim. Biophys. Acta. 1436:1998;127-150.
24. Yaffe M.B., Leparc G.G., Lai J., Obata T., Volinia S., Cantley L.C. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat. Biotechnol. 19:2001;348-353.
25. Grotzinger J. Molecular mechanisms of cytokine receptor activation. Biochim. Biophys. Acta. 1592:2002;215-223.
26. Irie H.Y., Ravichandran K.S., Burakoff S.J. CD8 beta chain influences CD8 alpha chain-associated Lck kinase activity. J. Exp. Med. 181:1995;1267-1273.
27. Blom N., Gammeltoft S., Brunak S. Sequence- and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol. 294:1999;1351-1362.
28. Y. Wen, T.C. Caffrey, M.J. Wheelock, K.R. Johnson, M.A. Hollingsworth, Nuclear association of the cytoplasmic tail of MUC1 and β-catenin, J. Biol. Chem. (2003) in press.
29. ctn. Biochem. Biophys. Res. Commun. 381:2001;440-443.
30. Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:1998;49-139.
31. Scherle P.A., Jones E.A., Favata M.F., Dauleria A.J., Covington M.B., Nurnberg S.A., Magolda R.L., Trxaskos J.M. Inhibition of MAP kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes. J. Immunol. 161:1998;5681-5686.
32. van der Bruggen T., Nijenhuis S., van Raaij E., Verhoef J., van Asbeck B.S. Lipopolysaccharide-induced tumor necrosis factor alpha production by human monocytes involves the raf/MEK1-MEK2/ERK1-ERK2 pathway. Infect. Immun. 67:1999;3824-3829.
33. Hilkens J., Ligtenberg M.J., Vos H.L., Litvinov S.V. Cell membrane associated mucins and their adhesion-modulating property. TIBS. 17:1992;359-363.
34. Lillehoj E.P., Hyun S.W., Kim B.T., Zhang X.G., Lee D.I., Rowland S., Kim K.C. Muc1 mucins on the cell surface are adhesion sites for Pseudomonas aeruginosa. Am. J. Physiol. (Lung Cell. Mol. Physiol.). 280:2001;L181-L187.
35. Lillehoj E.P., Kim B.T., Kim K.C. Identification of Pseudomonas aeruginosa flagellin as an adhesin for Muc1 mucin. Am. J. Physiol. (Lung Cell. Mol. Physiol.). 282:2002;L751-L756.