N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicininduced cytotoxicity through ROS-mediated release of cytochrome c and AIF

Apoptosis

Volumn 15, Issue 8, 2010, Pages 982-993

  Kim, Byeong Mo ^a   Choi, Yun Jung ^a   Lee, Yong Heon ^b   Joe, Young Ae ^c   Hong, Sung Hee ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Department of Obstetrics Gynecology   (United States)

^c The Catholic University of Korea   (South Korea)

Author keywords

Apoptosis; Caspase dependent; Caspase independent; N,N dimethyl phytosphingosine (DMPS); Reactive oxygen species (ROS); Sensitizing effect

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; BENZYLOXYCARBONYLVALINEALANINEASPARYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CYSTEINE PROTEINASE INHIBITOR; CYTOCHROME C; DOXORUBICIN; N, N DIMETHYL PHYTOSPHINGOSINE; PHYTOSPHINGOSINE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; ANTINEOPLASTIC ANTIBIOTIC; ANTIOXIDANT; APOPTOSIS INDUCING FACTOR; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE INHIBITOR; PEPTIDE CHLOROMETHYL KETONE; SCAVENGER; SPHINGOSINE;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER RESISTANCE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN SECRETION; ANALOGS AND DERIVATIVES; CELL SURVIVAL; DRUG EFFECTS; HL 60 CELL LINE; METABOLISM; MITOCHONDRION; MULTIDRUG RESISTANCE;

ACETYLCYSTEINE; AMINO ACID CHLOROMETHYL KETONES; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL SURVIVAL; CYSTEINE PROTEINASE INHIBITORS; CYTOCHROMES C; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ENZYME ACTIVATION; FREE RADICAL SCAVENGERS; HL-60 CELLS; HUMANS; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; SPHINGOSINE; CASPASE INHIBITORS;

EID: 77956897107     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-010-0512-x     Document Type: Article

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