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Volumn 72, Issue 9, 2011, Pages 687-698

Hepatitis B virus (HBV) core antigen-specific regulatory T cells confer sustained remission to anti-HBV therapy in chronic hepatitis B with acute exacerbation

Author keywords

Chronic hepatitis B; Gene profiling; HLA class II tetramer; Regulatory T cell clone; SYFPEITHI score

Indexed keywords

ADEFOVIR DIPIVOXIL; ALPHA INTERFERON; ENTECAVIR; EPITOPE; HEPATITIS B CORE ANTIGEN; HLA ANTIGEN CLASS 2; LAMIVUDINE; TETRAMER; TRANSCRIPTION FACTOR FOXP3;

EID: 84860389996     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.11.001     Document Type: Article
Times cited : (12)

References (62)
  • 1
    • 0027422748 scopus 로고
    • From hepatitis to hepatoma: lessons from type B viral hepatitis
    • Chen D.S. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993, 262:369-370.
    • (1993) Science , vol.262 , pp. 369-370
    • Chen, D.S.1
  • 2
    • 0030707941 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Lee W.M. Hepatitis B virus infection. N Engl J Med 1997, 337:1733-1745.
    • (1997) N Engl J Med , vol.337 , pp. 1733-1745
    • Lee, W.M.1
  • 3
    • 0037198749 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok A.S.F. Chronic hepatitis B. N Engl J Med 2002, 346:1682-1683.
    • (2002) N Engl J Med , vol.346 , pp. 1682-1683
    • Lok, A.S.F.1
  • 4
    • 3142654211 scopus 로고    scopus 로고
    • The challenge of emerging and re-emerging infectious diseases
    • Morens D.M., Folkers G.K., Fauci A.S. The challenge of emerging and re-emerging infectious diseases. Nature 2004, 430:242-249.
    • (2004) Nature , vol.430 , pp. 242-249
    • Morens, D.M.1    Folkers, G.K.2    Fauci, A.S.3
  • 5
    • 1542316127 scopus 로고    scopus 로고
    • Hepatitis B virus infection-natural history and clinical consequences
    • Ganem D., Prince A.M. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med 2004, 350:1118-1129.
    • (2004) N Engl J Med , vol.350 , pp. 1118-1129
    • Ganem, D.1    Prince, A.M.2
  • 6
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • El-Serag H.B., Rudolph K.L. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 7
    • 0017186994 scopus 로고
    • Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis
    • Greenberg H.B., Pollard R.B., Lutwick L.I., Gregory P.B., Robinson W.S., Merigan T.C. Effect of human leukocyte interferon on hepatitis B virus infection in patients with chronic active hepatitis. N Engl J Med 1976, 295:517-522.
    • (1976) N Engl J Med , vol.295 , pp. 517-522
    • Greenberg, H.B.1    Pollard, R.B.2    Lutwick, L.I.3    Gregory, P.B.4    Robinson, W.S.5    Merigan, T.C.6
  • 8
    • 84921010773 scopus 로고
    • Administration of human fibroblast interferon in chronic hepatitis B infection
    • Desmyter J., Ray M.B., De Groot J., Bradburne A.F., Desmet V.J., Edy V.G., et al. Administration of human fibroblast interferon in chronic hepatitis B infection. Lancet 1976, ii:645-647.
    • (1976) Lancet , vol.2 , pp. 645-647
    • Desmyter, J.1    Ray, M.B.2    De Groot, J.3    Bradburne, A.F.4    Desmet, V.J.5    Edy, V.G.6
  • 9
    • 1842291578 scopus 로고    scopus 로고
    • The treatment of chronic viral hepatitis
    • Hoofnagle J.H., DiBisceglie A.M. The treatment of chronic viral hepatitis. N Engl J Med 1997, 336:347-356.
    • (1997) N Engl J Med , vol.336 , pp. 347-356
    • Hoofnagle, J.H.1    DiBisceglie, A.M.2
  • 10
    • 0035189597 scopus 로고    scopus 로고
    • Chronic hepatitis B
    • Lok A.S.F., McMahon B.J. Chronic hepatitis B. Hepatol 2001, 34:1225-1241.
    • (2001) Hepatol , vol.34 , pp. 1225-1241
    • Lok, A.S.F.1    McMahon, B.J.2
  • 13
    • 54849146600 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Dienstag J.L. Hepatitis B virus infection. N Engl J Med 2008, 359:1486-1500.
    • (2008) N Engl J Med , vol.359 , pp. 1486-1500
    • Dienstag, J.L.1
  • 14
    • 0037366499 scopus 로고    scopus 로고
    • Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy
    • Liaw Y.F. Hepatitis flares and hepatitis B e antigen seroconversion: implication in anti-hepatitis B virus therapy. J Gastroenterol Hepatol 2003, 18:246-252.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 246-252
    • Liaw, Y.F.1
  • 15
    • 0037336224 scopus 로고    scopus 로고
    • The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B
    • Chien R.N., Lin C.L., Liaw Y.F. The effect of lamivudine therapy in hepatic decompensation during acute exacerbation of chronic hepatitis B. J Hepatol 2003, 38:322-327.
    • (2003) J Hepatol , vol.38 , pp. 322-327
    • Chien, R.N.1    Lin, C.L.2    Liaw, Y.F.3
  • 16
    • 67649616077 scopus 로고    scopus 로고
    • Efficacy of lamivudine therapy on decompensated liver cirrhosis due to chronic hepatitis B
    • Mashhour M.Y., Ghanaei F.M., Foroutan H., Ghofrani H., Purrasuli Z., Jourkar F. Efficacy of lamivudine therapy on decompensated liver cirrhosis due to chronic hepatitis B. Hep Mon 2007, 7:77-81.
    • (2007) Hep Mon , vol.7 , pp. 77-81
    • Mashhour, M.Y.1    Ghanaei, F.M.2    Foroutan, H.3    Ghofrani, H.4    Purrasuli, Z.5    Jourkar, F.6
  • 17
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman J.S., Pourcel C., Summers J. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 1986, 47:451-460.
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 18
    • 0022868402 scopus 로고
    • Hepatitis B virus RNA transcripts and DNA in chronic liver disease
    • Yokosuka O., Omata M., Imazeki F., Ito Y., Okuda K. Hepatitis B virus RNA transcripts and DNA in chronic liver disease. N Engl J Med 1986, 315:1187-1192.
    • (1986) N Engl J Med , vol.315 , pp. 1187-1192
    • Yokosuka, O.1    Omata, M.2    Imazeki, F.3    Ito, Y.4    Okuda, K.5
  • 20
    • 0032499922 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B infection
    • Omata M. Treatment of chronic hepatitis B infection. N Engl J Med 1998, 339:114-115.
    • (1998) N Engl J Med , vol.339 , pp. 114-115
    • Omata, M.1
  • 21
    • 0035123958 scopus 로고    scopus 로고
    • Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease
    • Perrillo R. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 2001, 102:1009-1022.
    • (2001) Gastroenterology , vol.102 , pp. 1009-1022
    • Perrillo, R.1
  • 22
    • 0029957570 scopus 로고    scopus 로고
    • Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection
    • Marinos G., Naoumov N.J., Williams R. Impact of complete inhibition of viral replication on the cellular immune response in chronic hepatitis B virus infection. Hepatology 1996, 24:991-995.
    • (1996) Hepatology , vol.24 , pp. 991-995
    • Marinos, G.1    Naoumov, N.J.2    Williams, R.3
  • 23
    • 0032169470 scopus 로고    scopus 로고
    • Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B
    • Boni C., Bertoletti A., Penna A., Cavalli A., Pilli M., Urbani S., et al. Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B. J Clin Invest 1998, 102:968-975.
    • (1998) J Clin Invest , vol.102 , pp. 968-975
    • Boni, C.1    Bertoletti, A.2    Penna, A.3    Cavalli, A.4    Pilli, M.5    Urbani, S.6
  • 24
    • 0033396247 scopus 로고    scopus 로고
    • Cell-mediated immune responses and loss of hepatitis B e-antigen (HBeAg) during successful lamivudine and famciclovir combination therapy for chronic replicating hepatitis B virus infection
    • Hultgren C., Weiland O., Milich D.R., Sallberg M. Cell-mediated immune responses and loss of hepatitis B e-antigen (HBeAg) during successful lamivudine and famciclovir combination therapy for chronic replicating hepatitis B virus infection. Clin Infect Dis 1999, 29:1575-1577.
    • (1999) Clin Infect Dis , vol.29 , pp. 1575-1577
    • Hultgren, C.1    Weiland, O.2    Milich, D.R.3    Sallberg, M.4
  • 25
    • 0033844153 scopus 로고    scopus 로고
    • Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B
    • Liaw Y.F., Tsai S.L., Chien R.N., Yeh C.T., Chu C.M. Prednisolone priming enhances Th1 response and efficacy of subsequent lamivudine therapy in patients with chronic hepatitis B. Hepatology 2000, 32:604-609.
    • (2000) Hepatology , vol.32 , pp. 604-609
    • Liaw, Y.F.1    Tsai, S.L.2    Chien, R.N.3    Yeh, C.T.4    Chu, C.M.5
  • 26
    • 17744383748 scopus 로고    scopus 로고
    • Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy
    • Boni C., Penna A., Ogg G.S., Bertoletti A., Pilli M., Cavallo C., et al. Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy. Hepatology 2001, 33:963-971.
    • (2001) Hepatology , vol.33 , pp. 963-971
    • Boni, C.1    Penna, A.2    Ogg, G.S.3    Bertoletti, A.4    Pilli, M.5    Cavallo, C.6
  • 27
    • 0037261447 scopus 로고    scopus 로고
    • Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications
    • Tsai S.L., Sheen I.S., Chien R.N., Chu C.M., Chuang Y.L., Lee T.H., et al. Activation of Th1 immunity is a common immune mechanism for the successful treatment of hepatitis B and C: tetramer assay and therapeutic implications. J Biomed Sci 2003, 10:120-135.
    • (2003) J Biomed Sci , vol.10 , pp. 120-135
    • Tsai, S.L.1    Sheen, I.S.2    Chien, R.N.3    Chu, C.M.4    Chuang, Y.L.5    Lee, T.H.6
  • 28
    • 10844242136 scopus 로고    scopus 로고
    • High frequency of functional anti-YMDD and -mutant cytotoxic T lymphocytes after in vitro expansion correlates with successful response to lamivudine therapy for chronic hepatitis B
    • Lin C.L., Tsai S.L., Lee T.H., Chien R.N., Liao S.K., Liaw Y.F. High frequency of functional anti-YMDD and -mutant cytotoxic T lymphocytes after in vitro expansion correlates with successful response to lamivudine therapy for chronic hepatitis B. Gut 2005, 54:152-161.
    • (2005) Gut , vol.54 , pp. 152-161
    • Lin, C.L.1    Tsai, S.L.2    Lee, T.H.3    Chien, R.N.4    Liao, S.K.5    Liaw, Y.F.6
  • 29
    • 0026527586 scopus 로고
    • Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion
    • Tsai S.L., Chen P.J., Lai M.Y., Yang P.M., Sung J.L., Huang J.H., et al. Acute exacerbations of chronic type B hepatitis are accompanied by increased T cell responses to hepatitis B core and e antigens. Implications for hepatitis B e antigen seroconversion. J Clin Invest 1992, 89:87-96.
    • (1992) J Clin Invest , vol.89 , pp. 87-96
    • Tsai, S.L.1    Chen, P.J.2    Lai, M.Y.3    Yang, P.M.4    Sung, J.L.5    Huang, J.H.6
  • 30
    • 0023203608 scopus 로고
    • Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection: hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis
    • Chu C.M., Liaw Y.F. Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection: hepatocyte with cytoplasmic/membranous hepatitis B core antigen as a possible target for immune hepatocytolysis. Gastroenterology 1987, 2:220-226.
    • (1987) Gastroenterology , vol.2 , pp. 220-226
    • Chu, C.M.1    Liaw, Y.F.2
  • 31
    • 0030045482 scopus 로고    scopus 로고
    • Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes
    • Tsai S.L., Chen M.H., Yeh C.T., Chu C.M., Lin A.N., Chiou F.H., et al. Purification and characterization of a naturally processed hepatitis B virus peptide recognized by CD8+ cytotoxic T lymphocytes. J Clin Invest 1996, 97:577-584.
    • (1996) J Clin Invest , vol.97 , pp. 577-584
    • Tsai, S.L.1    Chen, M.H.2    Yeh, C.T.3    Chu, C.M.4    Lin, A.N.5    Chiou, F.H.6
  • 32
    • 0029150110 scopus 로고
    • Immunological self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causing various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunological self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causing various autoimmune diseases. J Immunol 1995, 155:1151-1164.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 33
    • 20444490383 scopus 로고    scopus 로고
    • Regulation of immunity by self-reactive T cells
    • Kronenberg M., Rudenskym A.Y. Regulation of immunity by self-reactive T cells. Nature 2005, 435:598-604.
    • (2005) Nature , vol.435 , pp. 598-604
    • Kronenberg, M.1    Rudenskym, A.Y.2
  • 34
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid Y., Rouse B. Natural regulatory T cells in infectious disease. Nat Immunol 2005, 6:353-359.
    • (2005) Nat Immunol , vol.6 , pp. 353-359
    • Belkaid, Y.1    Rouse, B.2
  • 36
    • 16244385911 scopus 로고    scopus 로고
    • Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection
    • Stoop J.N., van der Molen R.G., Baan C.C., van der Laan L.J.W., Kuipers E.J., Kusters J.G., et al. Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection. Hepatology 2005, 41:771-778.
    • (2005) Hepatology , vol.41 , pp. 771-778
    • Stoop, J.N.1    van der Molen, R.G.2    Baan, C.C.3    van der Laan, L.J.W.4    Kuipers, E.J.5    Kusters, J.G.6
  • 37
    • 14744271751 scopus 로고    scopus 로고
    • Modulation of the CD8+ T cell response by CD4+ D25+ regulatory T cells in patients with hepatitis B virus infection
    • Franzese O., Kennedy P.T.F., Gehring A.J., Gotto J., Williams R., Maini M.K., et al. Modulation of the CD8+ T cell response by CD4+ D25+ regulatory T cells in patients with hepatitis B virus infection. J Virol 2005, 79:3322-3328.
    • (2005) J Virol , vol.79 , pp. 3322-3328
    • Franzese, O.1    Kennedy, P.T.F.2    Gehring, A.J.3    Gotto, J.4    Williams, R.5    Maini, M.K.6
  • 38
    • 33745323050 scopus 로고    scopus 로고
    • Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B
    • Xu D., Fu J., Jin L., Zhang H., Zho C., Zou Z., et al. Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B. J Immunol 2006, 177:739-747.
    • (2006) J Immunol , vol.177 , pp. 739-747
    • Xu, D.1    Fu, J.2    Jin, L.3    Zhang, H.4    Zho, C.5    Zou, Z.6
  • 39
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection
    • Cabrera R., Tu Z., Xu Y., Firpi R.J., Rosen H.R., Liu C., et al. An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection. Hepatology 2004, 40:1062-1071.
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6
  • 40
    • 33847096821 scopus 로고    scopus 로고
    • HBcAg-specific CD4+CD25+ regulatory T cells modulate immune tolerance and acute exacerbation on the natural history of chronic hepatitis B virus infection
    • Feng I.C., Koay L.B., Sheu M.J., Kuo H.T., Sun C.S., Lee C., et al. HBcAg-specific CD4+CD25+ regulatory T cells modulate immune tolerance and acute exacerbation on the natural history of chronic hepatitis B virus infection. J Biomed Sci 2007, 14:43-57.
    • (2007) J Biomed Sci , vol.14 , pp. 43-57
    • Feng, I.C.1    Koay, L.B.2    Sheu, M.J.3    Kuo, H.T.4    Sun, C.S.5    Lee, C.6
  • 41
    • 66549116951 scopus 로고    scopus 로고
    • Wnt-1 protein as a prognostic biomarker for hepatitis B-related and hepatitis C-related hepatocellular carcinoma after surgery
    • Lee H.H., Uen Y.H., Tian Y.F., Sun C.S., Sheu M.J., Kuo H.T., et al. Wnt-1 protein as a prognostic biomarker for hepatitis B-related and hepatitis C-related hepatocellular carcinoma after surgery. Cancer Epidemiol Biomarkers Prev 2009, 18:1562-1569.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 1562-1569
    • Lee, H.H.1    Uen, Y.H.2    Tian, Y.F.3    Sun, C.S.4    Sheu, M.J.5    Kuo, H.T.6
  • 42
    • 0142244873 scopus 로고    scopus 로고
    • Determinants for sustained HBeAg response to lamivudine therapy
    • Chien R.N., Yeh C.T., Tsai S.L., Chu C.M., Liaw Y.F. Determinants for sustained HBeAg response to lamivudine therapy. Hepatology 2003, 38:1267-1273.
    • (2003) Hepatology , vol.38 , pp. 1267-1273
    • Chien, R.N.1    Yeh, C.T.2    Tsai, S.L.3    Chu, C.M.4    Liaw, Y.F.5
  • 44
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H)17: the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    • Steinman L. A brief history of T(H)17: the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat Med 2007, 13:139-145.
    • (2007) Nat Med , vol.13 , pp. 139-145
    • Steinman, L.1
  • 45
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector function of T(H)17 cells
    • Bettelli E., Korn T., Oukka M., Kuchroo V. Induction and effector function of T(H)17 cells. Nature 2008, 453:1051-1057.
    • (2008) Nature , vol.453 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.4
  • 46
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: an updated view of their molecular identity and genetic programming
    • Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008, 8:337-348.
    • (2008) Nat Rev Immunol , vol.8 , pp. 337-348
    • Dong, C.1
  • 48
    • 42449120125 scopus 로고    scopus 로고
    • T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
    • Óshea J.J., Hunter C.A., Germain R.N. T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?. Nat Immunol 2008, 5:450-453.
    • (2008) Nat Immunol , vol.5 , pp. 450-453
    • Óshea, J.J.1    Hunter, C.A.2    Germain, R.N.3
  • 49
    • 0036330580 scopus 로고    scopus 로고
    • Effects of lamivudine on the hepatitis B virusspecific CD8+ cytotoxic T lymphocyte response via peptide-MHC tetrameric complexesassay
    • Lee T.H., Huang C.Y.L., Tsai S.L., Liaw Y.F. Effects of lamivudine on the hepatitis B virusspecific CD8+ cytotoxic T lymphocyte response via peptide-MHC tetrameric complexesassay. Lett Pept Sci 2002, 8:179-185.
    • (2002) Lett Pept Sci , vol.8 , pp. 179-185
    • Lee, T.H.1    Huang, C.Y.L.2    Tsai, S.L.3    Liaw, Y.F.4
  • 51
    • 0031026553 scopus 로고
    • Detection of type-2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity
    • Tsai S.L., Liaw Y.F., Chen M.H., Huang C.Y., Kuo G.C. Detection of type-2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicity. Hepatology 1977, 25:449-458.
    • (1977) Hepatology , vol.25 , pp. 449-458
    • Tsai, S.L.1    Liaw, Y.F.2    Chen, M.H.3    Huang, C.Y.4    Kuo, G.C.5
  • 52
    • 0031680261 scopus 로고    scopus 로고
    • Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity
    • Tsai S.L., Chen M.H., Huang C.Y., Chen Y.M., Sheen I.S., Yeh C.T., et al. Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity. Gastroenterology 1998, 115:954-966.
    • (1998) Gastroenterology , vol.115 , pp. 954-966
    • Tsai, S.L.1    Chen, M.H.2    Huang, C.Y.3    Chen, Y.M.4    Sheen, I.S.5    Yeh, C.T.6
  • 54
    • 0033392612 scopus 로고    scopus 로고
    • MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen
    • Novak E.J., Liu A.W., Nepom G.T., Kwok W.W. MHC class II tetramers identify peptide-specific human CD4+ T cells proliferating in response to influenza A antigen. J Clin Invest 1999, 104:R63-R66.
    • (1999) J Clin Invest , vol.104
    • Novak, E.J.1    Liu, A.W.2    Nepom, G.T.3    Kwok, W.W.4
  • 55
    • 0034992147 scopus 로고    scopus 로고
    • Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset
    • Novak E.J., Masewicz S.A., Liu A.W., Lernmark Å., Kwok W.W., Nepom G.T. Activated human epitope-specific T cells identified by class II tetramers reside within a CD4high, proliferating subset. Int Immunol 2001, 13:799-806.
    • (2001) Int Immunol , vol.13 , pp. 799-806
    • Novak, E.J.1    Masewicz, S.A.2    Liu, A.W.3    Lernmark, Å.4    Kwok, W.W.5    Nepom, G.T.6
  • 57
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D., Rasmussen J.P., Gavin M.A., Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005, 6:1142-1151.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 58
    • 0020682268 scopus 로고
    • Postnatal infectivity of hepatitis B surface antigen-carrier mothers
    • Beasley R.P., Hwang L.Y. Postnatal infectivity of hepatitis B surface antigen-carrier mothers. J Infect Dis 1983, 147:185-190.
    • (1983) J Infect Dis , vol.147 , pp. 185-190
    • Beasley, R.P.1    Hwang, L.Y.2
  • 59
    • 0017329452 scopus 로고
    • The e antigen and vertical transmission of hepatitis B surface antigen
    • Beasley R.P., Trepo C., Stevens C.E., Szmuness W. The e antigen and vertical transmission of hepatitis B surface antigen. Am J Epidemiol 1977, 105:94-98.
    • (1977) Am J Epidemiol , vol.105 , pp. 94-98
    • Beasley, R.P.1    Trepo, C.2    Stevens, C.E.3    Szmuness, W.4
  • 61
    • 84983725895 scopus 로고    scopus 로고
    • Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion
    • Ni Y.H., Chang M.H., Chen P.J., Tsai K.S., Hsu H.Y., Chen H.L., et al. Viremia profiles in children with chronic hepatitis B virus infection and spontaneous e antigen seroconversion. Gastroenterology 2007, 132:2340-2345.
    • (2007) Gastroenterology , vol.132 , pp. 2340-2345
    • Ni, Y.H.1    Chang, M.H.2    Chen, P.J.3    Tsai, K.S.4    Hsu, H.Y.5    Chen, H.L.6
  • 62
    • 0025819555 scopus 로고
    • Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides
    • Milich D.R., McLachlan A., Raney A.K., Houghten R., Thornton G.B., Maruyama T., et al. Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. Proc Natl Acad Sci U S A 1991, 88:4348-4352.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 4348-4352
    • Milich, D.R.1    McLachlan, A.2    Raney, A.K.3    Houghten, R.4    Thornton, G.B.5    Maruyama, T.6


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